{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:03:08Z","timestamp":1758042188685,"version":"3.44.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3636,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.2353\/ajpath.2010.090499","type":"journal-article","created":{"date-parts":[[2009,12,30]],"date-time":"2009-12-30T22:01:38Z","timestamp":1262210498000},"page":"995-1005","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Influence of Hoxa5 on p53 Tumorigenic Outcome in Mice"],"prefix":"10.1016","volume":"176","author":[{"given":"Ga\u00eblle","family":"Gendronneau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Lemieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Morneau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e","family":"Paradis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"T\u00eatu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Frenette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9e","family":"Aubin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Jeannotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2010.090499_bib1","first-page":"3551","article-title":"Database of p53 gene somatic mutations in human tumors and cell lines","volume":"22","author":"Hollstein","year":"1994","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090499_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/356215a0","article-title":"Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors","volume":"356","author":"Donehower","year":"1992","journal-title":"Nature"},{"key":"10.2353\/ajpath.2010.090499_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","article-title":"Tumor spectrum analysis in p53-mutant mice","volume":"4","author":"Jacks","year":"1994","journal-title":"Curr Biol"},{"key":"10.2353\/ajpath.2010.090499_bib4","first-page":"603","article-title":"Tumor incidence, spectrum and ploidy in mice with a large deletion in the p53 gene","volume":"9","author":"Purdie","year":"1994","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090499_bib5","first-page":"1717","article-title":"Synergy between a human c-myc transgene and p53 null genotype in murine thymic lymphomas: contrasting effects of homozygous and heterozygous p53 loss","volume":"10","author":"Blyth","year":"1995","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090499_bib6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1128\/MCB.17.2.723","article-title":"Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53","volume":"17","author":"Hundley","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2010.090499_bib7","first-page":"829","article-title":"Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis","volume":"8","author":"Jones","year":"1997","journal-title":"Cell Growth Differ"},{"key":"10.2353\/ajpath.2010.090499_bib8","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1073\/pnas.96.6.3092","article-title":"Cooperative action of germ-line mutations in decorin and p53 accelerates lymphoma tumorigenesis","volume":"96","author":"Iozzo","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090499_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrc907","article-title":"Deregulated homeobox gene expression in cancer: cause or consequence?","volume":"2","author":"Abate-Shen","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.2353\/ajpath.2010.090499_bib10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0092-8674(94)90290-9","article-title":"Hox genes in vertebrate development","volume":"78","author":"Krumlauf","year":"1994","journal-title":"Cell"},{"key":"10.2353\/ajpath.2010.090499_bib11","first-page":"38","article-title":"HOX genes in human cancers","volume":"14","author":"Cillo","year":"1994","journal-title":"Invasion Metastasis"},{"key":"10.2353\/ajpath.2010.090499_bib12","first-page":"673","article-title":"Aberrant expression of HOX genes in human invasive breast carcinoma","volume":"13","author":"Makiyama","year":"2005","journal-title":"Oncol Rep"},{"key":"10.2353\/ajpath.2010.090499_bib13","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ncb1464","article-title":"Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L","volume":"8","author":"Okada","year":"2006","journal-title":"Nat Cell Biol"},{"key":"10.2353\/ajpath.2010.090499_bib14","first-page":"753","article-title":"Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma","volume":"17","author":"Takahashi","year":"2007","journal-title":"Oncol Rep"},{"key":"10.2353\/ajpath.2010.090499_bib15","doi-asserted-by":"crossref","first-page":"7177","DOI":"10.1158\/0008-5472.CAN-04-1717","article-title":"Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model","volume":"65","author":"Carrio","year":"2005","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090499_bib16","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1128\/MCB.24.2.924-935.2004","article-title":"HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8","volume":"24","author":"Chen","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2010.090499_bib17","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1593\/neo.05766","article-title":"HOXA5 regulates hMLH1 expression in breast cancer cells","volume":"8","author":"Duriseti","year":"2006","journal-title":"Neoplasia"},{"key":"10.2353\/ajpath.2010.090499_bib18","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1089\/lrb.2005.3.240","article-title":"A role for Hox A5 in regulating angiogenesis and vascular patterning","volume":"3","author":"Rhoads","year":"2005","journal-title":"Lymphat Res Biol"},{"key":"10.2353\/ajpath.2010.090499_bib19","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1158\/0008-5472.CAN-06-4283","article-title":"A role for the HOXB7 homeodomain protein in DNA repair","volume":"67","author":"Rubin","year":"2007","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090499_bib20","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0959-8049(97)00010-5","article-title":"Homeobox genes: molecular link between congenital anomalies and cancer","volume":"33","author":"Anbazhagan","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.2353\/ajpath.2010.090499_bib21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4161\/cbt.3.6.848","article-title":"HOXA10 regulates p53 expression and matrigel invasion in human breast cancer cells","volume":"3","author":"Chu","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"10.2353\/ajpath.2010.090499_bib22","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/35016125","article-title":"Compromised HOXA5 function can limit p53 expression in human breast tumours","volume":"405","author":"Raman","year":"2000","journal-title":"Nature"},{"key":"10.2353\/ajpath.2010.090499_bib23","first-page":"305","article-title":"Expression pattern of a homeotic gene: HOXA5, in normal breast and in breast tumors","volume":"28","author":"Henderson","year":"2006","journal-title":"Cell Oncol"},{"key":"10.2353\/ajpath.2010.090499_bib24","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1101\/gad.7.11.2085","article-title":"Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene","volume":"7","author":"Jeannotte","year":"1993","journal-title":"Genes Dev"},{"key":"10.2353\/ajpath.2010.090499_bib25","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1006\/dbio.1997.8746","article-title":"Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects","volume":"192","author":"Aubin","year":"1997","journal-title":"Dev Biol"},{"key":"10.2353\/ajpath.2010.090499_bib26","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1242\/dev.129.17.4075","article-title":"Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling","volume":"129","author":"Aubin","year":"2002","journal-title":"Development"},{"key":"10.2353\/ajpath.2010.090499_bib27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/dvdy.10325","article-title":"Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice","volume":"227","author":"Meunier","year":"2003","journal-title":"Dev Dyn"},{"key":"10.2353\/ajpath.2010.090499_bib28","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1002\/dvdy.20822","article-title":"Stromal Hoxa5 function controls the growth and differentiation of mammary alveolar epithelium","volume":"235","author":"Garin","year":"2006","journal-title":"Dev Dyn"},{"key":"10.2353\/ajpath.2010.090499_bib29","first-page":"797","article-title":"Disordered expression of HOX genes in human non-small cell lung cancer","volume":"15","author":"Abe","year":"2006","journal-title":"Oncol Rep"},{"key":"10.2353\/ajpath.2010.090499_bib30","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1158\/1078-0432.CCR-07-0919","article-title":"Inactivation of HOXA genes by hypermethylation in myeloid and lymphoid malignancy is frequent and associated with poor prognosis","volume":"13","author":"Strathdee","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090499_bib31","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1073\/pnas.95.9.5076","article-title":"A paracrine role for the epithelial progesterone receptor in mammary gland development","volume":"95","author":"Brisken","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090499_bib32","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.4049\/jimmunol.145.10.3474","article-title":"Analysis of beta 2- microglobulin gene expression in the developing mouse embryo and placenta","volume":"145","author":"Jaffe","year":"1990","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.090499_bib33","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/sj.onc.1210827","article-title":"Mtbp haploinsufficiency in mice increases tumor metastasis","volume":"27","author":"Iwakuma","year":"2008","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090499_bib34","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1667\/RR0820.1","article-title":"p53 (TRP53) deficiency-mediated antiapoptosis escape after 5 Gy X irradiation still induces stem cell leukemia in C3H\/He mice: comparison between whole-body assay and bone marrow transplantation (BMT) assay","volume":"167","author":"Yoshida","year":"2007","journal-title":"Radiat Res"},{"key":"10.2353\/ajpath.2010.090499_bib35","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1158\/0008-5472.CAN-03-3435","article-title":"Loss of heterozygosity occurs via mitotic recombination in Trp53+\/\u2212 mice and associates with mammary tumor susceptibility of the BALB\/c strain","volume":"64","author":"Blackburn","year":"2004","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090499_bib36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/(SICI)1097-0177(199805)212:1<141::AID-AJA13>3.0.CO;2-A","article-title":"Transcriptional interferences at the Hoxa4\/Hoxa5 locus: importance of correct Hoxa5 expression for the proper specification of the axial skeleton","volume":"212","author":"Aubin","year":"1998","journal-title":"Dev Dyn"},{"key":"10.2353\/ajpath.2010.090499_bib37","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1096\/fasebj.7.10.8344491","article-title":"Genetic background alters the spectrum of tumors that develop in p53-deficient mice","volume":"7","author":"Harvey","year":"1993","journal-title":"FASEB J"},{"key":"10.2353\/ajpath.2010.090499_bib38","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1038\/sj.leu.2404396","article-title":"Identification of Notch target genes in uncommitted T-cell progenitors: no direct induction of a T-cell specific gene program","volume":"20","author":"Weerkamp","year":"2006","journal-title":"Leukemia"},{"key":"10.2353\/ajpath.2010.090499_bib39","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/sj.onc.1203277","article-title":"The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting","volume":"19","author":"Cardiff","year":"2000","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090499_bib40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2307\/3579468","article-title":"Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation","volume":"146","author":"Ullrich","year":"1996","journal-title":"Radiat Res"},{"key":"10.2353\/ajpath.2010.090499_bib41","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/mc.2940140105","article-title":"Effects of genetic background on tumorigenesis in p53-deficient mice","volume":"14","author":"Donehower","year":"1995","journal-title":"Mol Carcinog"},{"key":"10.2353\/ajpath.2010.090499_bib42","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0960-9822(95)00183-7","article-title":"High-frequency developmental abnormalities in p53-deficient mice","volume":"5","author":"Armstrong","year":"1995","journal-title":"Curr Biol"},{"key":"10.2353\/ajpath.2010.090499_bib43","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ng0695-175","article-title":"A subset of p53-deficient embryos exhibit exencephaly","volume":"10","author":"Sah","year":"1995","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2010.090499_bib44","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/sj.leu.2403891","article-title":"CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes","volume":"19","author":"Dik","year":"2005","journal-title":"Leukemia"},{"key":"10.2353\/ajpath.2010.090499_bib45","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/dvg.20292","article-title":"Comparative analysis of Hoxa5 allelic series","volume":"45","author":"Tabari\u00e8s","year":"2007","journal-title":"Genesis"},{"key":"10.2353\/ajpath.2010.090499_bib46","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1158\/0008-5472.CAN-07-2017","article-title":"Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype","volume":"68","author":"Sarrio","year":"2008","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090499_bib47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2214\/AJR.07.2909","article-title":"Angiosarcoma of the breast","volume":"190","author":"Glazebrook","year":"2008","journal-title":"AJR Am J Roentgenol"},{"key":"10.2353\/ajpath.2010.090499_bib48","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1023\/A:1005997017102","article-title":"Angiosarcoma of the breast after conservation therapy for invasive cancer, the incidence and outcome: an unforeseen sequela","volume":"47","author":"Strobbe","year":"1998","journal-title":"Breast Cancer Res Treat"},{"key":"10.2353\/ajpath.2010.090499_bib49","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/COC.0b013e3181131d62","article-title":"Angiosarcomas of the breast: a review of 70 cases","volume":"30","author":"Hodgson","year":"2007","journal-title":"Am J Clin Oncol"},{"key":"10.2353\/ajpath.2010.090499_bib50","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/S0002-9440(10)64853-5","article-title":"Development of spontaneous mammary tumors in BALB\/c p53 heterozygous mice: a model for Li-Fraumeni syndrome","volume":"157","author":"Kuperwasser","year":"2000","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2010.090499_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s12032-008-9073-z","article-title":"Analysis of differential therapeutic strategies for primary breast lymphoma: two case reports","volume":"26","author":"Stasi","year":"2009","journal-title":"Med Oncol"},{"key":"10.2353\/ajpath.2010.090499_bib52","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2407-8-86","article-title":"Primary breast lymphoma: patient profile, outcome and prognostic factors; a multicentre Rare Cancer Network study","volume":"8","author":"Jeanneret-Sozzi","year":"2008","journal-title":"BMC Cancer"},{"key":"10.2353\/ajpath.2010.090499_bib53","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2325\/jbcs.12.149","article-title":"A case of carcinosarcoma of the breast","volume":"12","author":"Tokudome","year":"2005","journal-title":"Breast Cancer"},{"key":"10.2353\/ajpath.2010.090499_bib54","first-page":"413","article-title":"Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas","volume":"6","author":"Varley","year":"1991","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090499_bib55","first-page":"1301","article-title":"Tumorigenesis in Mlh1 and Mlh1\/Apc1638N mutant mice","volume":"59","author":"Edelmann","year":"1999","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090499_bib56","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1177\/1066896907302116","article-title":"Mismatch repair genes hMLH1 and hMSH2 may not play an essential role in breast carcinogenesis","volume":"15","author":"Khilko","year":"2007","journal-title":"Int J Surg Pathol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010604099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010604099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:03:53Z","timestamp":1757599433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010604099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":56,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S0002944010604099"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2010.090499","relation":{},"ISSN":["0002-9440"],"issn-type":[{"type":"print","value":"0002-9440"}],"subject":[],"published":{"date-parts":[[2010,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of Hoxa5 on p53 Tumorigenic Outcome in Mice","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2010.090499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}