{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:23:25Z","timestamp":1792653805431,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,1,1]],"date-time":"2010-01-01T00:00:00Z","timestamp":1262304000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3667,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.2353\/ajpath.2010.090552","type":"journal-article","created":{"date-parts":[[2009,12,11]],"date-time":"2009-12-11T21:49:35Z","timestamp":1260568175000},"page":"288-303","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["MicroRNAs May Mediate the Down-Regulation of Neurokinin-1 Receptor in Chronic Bladder Pain Syndrome"],"prefix":"10.1016","volume":"176","author":[{"given":"Veronica","family":"Sanchez Freire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona C.","family":"Burkhard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Draeger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Monastyrskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2010.090552_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.eururo.2007.09.019","article-title":"Diagnostic criteria, classification, and nomenclature for painful bladder syndrome\/interstitial cystitis: an ESSIC proposal","volume":"53","author":"van de Merwe","year":"2008","journal-title":"Eur Urol"},{"key":"10.2353\/ajpath.2010.090552_bib2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0022-5347(01)61947-5","article-title":"Epidemiology of interstitial cystitis: a population based study","volume":"161","author":"Curhan","year":"1999","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.eururo.2008.03.086","article-title":"Treatment of bladder pain syndrome\/interstitial cystitis: can we make evidence-based decisions?","volume":"54","author":"Fall","year":"2008","journal-title":"Eur Urol"},{"key":"10.2353\/ajpath.2010.090552_bib4","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1517\/14656560802519845","article-title":"Interstitial cystitis: bladder pain and beyond","volume":"9","author":"Theoharides","year":"2008","journal-title":"Expert Opin Pharmacother"},{"key":"10.2353\/ajpath.2010.090552_bib5","first-page":"493","article-title":"Bladder surface glycosaminoglycans is a human epithelial permeability barrier","volume":"171","author":"Lilly","year":"1990","journal-title":"Surg Gynecol Obstet"},{"key":"10.2353\/ajpath.2010.090552_bib6","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0022-5347(17)34944-3","article-title":"Decreased expression of a glycoprotein component of bladder surface mucin (GP1) in interstitial cystitis","volume":"151","author":"Moskowitz","year":"1994","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib7","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1016\/j.cellsig.2008.06.004","article-title":"Cell signaling in interstitial cystitis\/painful bladder syndrome","volume":"20","author":"Keay","year":"2008","journal-title":"Cell Signal"},{"key":"10.2353\/ajpath.2010.090552_bib8","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0022-5347(17)37314-7","article-title":"Interstitial cystitis: increased sympathetic innervation and related neuropeptide synthesis","volume":"147","author":"Hohenfellner","year":"1992","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib9","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/j.1464-410X.1995.tb07384.x","article-title":"Increased number of substance P positive nerve fibres in interstitial cystitis","volume":"75","author":"Pang","year":"1995","journal-title":"Br J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib10","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0090-4295(01)01100-1","article-title":"Urinary substance P concentration correlates with urinary frequency and urgency in interstitial cystitis patients treated with intravesical dimethyl sulfoxide and not intravesical anesthetic cocktail","volume":"57","author":"Kushner","year":"2001","journal-title":"Urology"},{"key":"10.2353\/ajpath.2010.090552_bib11","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/08830180802262765","article-title":"G protein-coupled receptor connectivity to NF-kappaB in inflammation and cancer","volume":"27","author":"Fraser","year":"2008","journal-title":"Int Rev Immunol"},{"key":"10.2353\/ajpath.2010.090552_bib12","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0002-9440(10)64944-9","article-title":"Neurokinin-1 (NK-1) receptor is required in antigen-induced cystitis","volume":"156","author":"Saban","year":"2000","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2010.090552_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0143-4179(98)90015-4","article-title":"The tachykinin NK1 receptor. Part II: distribution and pathophysiological roles","volume":"32","author":"Quartara","year":"1998","journal-title":"Neuropeptides"},{"key":"10.2353\/ajpath.2010.090552_bib14","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1476-5381.1994.tb14800.x","article-title":"Tachykinin NK1 receptor subtypes in the rat urinary bladder","volume":"111","author":"Meini","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.2353\/ajpath.2010.090552_bib15","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.lfs.2004.10.004","article-title":"Tachykinins and tachykinin receptors: effects in the genitourinary tract","volume":"76","author":"Candenas","year":"2005","journal-title":"Life Sci"},{"key":"10.2353\/ajpath.2010.090552_bib16","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1464-410X.1998.00507.x","article-title":"Increased expression of substance P receptor-encoding mRNA in bladder biopsies from patients with interstitial cystitis","volume":"81","author":"Marchand","year":"1998","journal-title":"Br J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib17","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1046\/j.1440-1681.2003.03887.x","article-title":"Human tachykinin NK2 receptor: a comparative study of the colon and urinary bladder","volume":"30","author":"Warner","year":"2003","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.2353\/ajpath.2010.090552_bib18","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0022-5347(05)68047-0","article-title":"Autoradiographic localization of tachykinin and calcitonin gene-related peptide receptors in adult urinary bladder","volume":"163","author":"Burcher","year":"2000","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0022-5347(01)67290-2","article-title":"Tachykinin effects on bladder activity in conscious normal rats","volume":"154","author":"Ishizuka","year":"1995","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib20","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0022-5347(05)66515-9","article-title":"Up-regulation of a gene homologous to the human tumor necrosis factor receptor associated factor 6 gene in the obstructed rabbit bladder determined by differential display polymerase chain reaction","volume":"165","author":"Burkhard","year":"2001","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib21","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/sj.bjp.0702769","article-title":"Pharmacological and molecular evidence for kinin B1 receptor expression in urinary bladder of cyclophosphamide-treated rats","volume":"128","author":"Belichard","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.2353\/ajpath.2010.090552_bib22","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1113\/jphysiol.2004.071159","article-title":"Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium","volume":"562","author":"Chopra","year":"2005","journal-title":"J Physiol"},{"key":"10.2353\/ajpath.2010.090552_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.autneu.2005.07.005","article-title":"Altered muscarinic receptor subtype expression and functional responses in cyclophosphamide induced cystitis in rats","volume":"122","author":"Giglio","year":"2005","journal-title":"Auton Neurosci"},{"key":"10.2353\/ajpath.2010.090552_bib24","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.juro.2008.10.138","article-title":"Mucosal muscarinic receptors enhance bladder activity in cats with feline interstitial cystitis","volume":"181","author":"Ikeda","year":"2009","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib25","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0002-9440(10)61159-5","article-title":"Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation","volume":"160","author":"Saban","year":"2002","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2010.090552_bib26","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1097\/01.ju.0000118938.09119.a5","article-title":"Abnormal expression of molecular markers for bladder impermeability and differentiation in the urothelium of patients with interstitial cystitis","volume":"171","author":"Slobodov","year":"2004","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib27","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.juro.2007.09.022","article-title":"Abnormal expression of differentiation related proteins and proteoglycan core proteins in the urothelium of patients with interstitial cystitis","volume":"179","author":"Hauser","year":"2008","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib28","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1097\/01.ju.0000180417.11976.99","article-title":"Regulation of tight junction proteins and bladder epithelial paracellular permeability by an antiproliferative factor from patients with interstitial cystitis","volume":"174","author":"Zhang","year":"2005","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib29","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1073\/pnas.0610731104","article-title":"MicroRNA-155 is induced during the macrophage inflammatory response","volume":"104","author":"O'Connell","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090552_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1582-4934.2008.00534.x","article-title":"Advances in microRNAs: implications for immunity and inflammatory diseases","volume":"13","author":"Sonkoly","year":"2009","journal-title":"J Cell Mol Med"},{"key":"10.2353\/ajpath.2010.090552_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/430161a","article-title":"The RNAi revolution","volume":"430","author":"Novina","year":"2004","journal-title":"Nature"},{"key":"10.2353\/ajpath.2010.090552_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.semcancer.2008.01.005","article-title":"MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation","volume":"18","author":"Sonkoly","year":"2008","journal-title":"Semin Cancer Biol"},{"key":"10.2353\/ajpath.2010.090552_bib33","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/1471-2164-8-240","article-title":"Expression profiling in vivo demonstrates rapid changes in lung microRNA levels following lipopolysaccharide-induced inflammation but not in the anti-inflammatory action of glucocorticoids","volume":"8","author":"Moschos","year":"2007","journal-title":"BMC Genomics"},{"key":"10.2353\/ajpath.2010.090552_bib34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/nau.10066","article-title":"Good urodynamic practices: uroflowmetry, filling cystometry, and pressure-flow studies","volume":"21","author":"Schafer","year":"2002","journal-title":"Neurourol Urodyn"},{"key":"10.2353\/ajpath.2010.090552_bib35","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0090-4295(02)02243-4","article-title":"The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society","volume":"61","author":"Abrams","year":"2003","journal-title":"Urology"},{"key":"10.2353\/ajpath.2010.090552_bib36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1289\/ehp.01109801","article-title":"The immortalized UROtsa cell line as a potential cell culture model of human urothelium","volume":"109","author":"Rossi","year":"2001","journal-title":"Environ Health Perspect"},{"key":"10.2353\/ajpath.2010.090552_bib37","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/nau.20103","article-title":"Smooth muscle membrane organization in the normal and dysfunctional human urinary bladder: a structural analysis","volume":"24","author":"Burkhard","year":"2005","journal-title":"Neurourol Urodyn"},{"key":"10.2353\/ajpath.2010.090552_bib38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ceca.2006.06.008","article-title":"Annexins as intracellular calcium sensors","volume":"41","author":"Monastyrskaya","year":"2007","journal-title":"Cell Calcium"},{"key":"10.2353\/ajpath.2010.090552_bib39","doi-asserted-by":"crossref","first-page":"D109","DOI":"10.1093\/nar\/gkh023","article-title":"The microRNA Registry","volume":"32","author":"Griffiths-Jones","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090552_bib40","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090552_bib41","doi-asserted-by":"crossref","first-page":"D154","DOI":"10.1093\/nar\/gkm952","article-title":"miRBase: tools for microRNA genomics","volume":"36","author":"Griffiths-Jones","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090552_bib42","doi-asserted-by":"crossref","first-page":"D149","DOI":"10.1093\/nar\/gkm995","article-title":"The microRNA.org resource: targets and expression","volume":"36","author":"Betel","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090552_bib43","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/bioinformatics\/18.1.207","article-title":"Genesis: cluster analysis of microarray data","volume":"18","author":"Sturn","year":"2002","journal-title":"Bioinformatics"},{"key":"10.2353\/ajpath.2010.090552_bib44","doi-asserted-by":"crossref","first-page":"F1084","DOI":"10.1152\/ajprenal.00118.2004","article-title":"Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis","volume":"287","author":"Birder","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.2353\/ajpath.2010.090552_bib45","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1464-410X.2004.04858.x","article-title":"P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis","volume":"93","author":"Tempest","year":"2004","journal-title":"BJU Int"},{"key":"10.2353\/ajpath.2010.090552_bib46","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1016\/j.yexcr.2006.07.012","article-title":"Phenotypic conversion leads to structural and functional changes of smooth muscle sarcolemma","volume":"312","author":"Matschke","year":"2006","journal-title":"Exp Cell Res"},{"key":"10.2353\/ajpath.2010.090552_bib47","doi-asserted-by":"crossref","first-page":"7135","DOI":"10.1074\/jbc.M405806200","article-title":"The NK1 receptor localizes to the plasma membrane microdomains, and its activation is dependent on lipid raft integrity","volume":"280","author":"Monastyrskaya","year":"2005","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090552_bib48","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.mehy.2004.04.012","article-title":"Dopamine receptor downregulation: an alternative strategy for schizophrenia treatment","volume":"63","author":"Tsai","year":"2004","journal-title":"Med Hypotheses"},{"key":"10.2353\/ajpath.2010.090552_bib49","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/abio.1996.0166","article-title":"Measurement of intracellular calcium in cell populations loaded with aequorin: neurokinin-1 responses in U373MG cells","volume":"236","author":"Hedley","year":"1996","journal-title":"Anal Biochem"},{"key":"10.2353\/ajpath.2010.090552_bib50","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and Mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"key":"10.2353\/ajpath.2010.090552_bib51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11626-008-9116-y","article-title":"Characterization of tight junction proteins in cultured human urothelial cells","volume":"44","author":"Rickard","year":"2008","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"10.2353\/ajpath.2010.090552_bib52","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1074\/jbc.M408122200","article-title":"Extracellular signal-regulated kinases 1\/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells","volume":"280","author":"Lipschutz","year":"2005","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090552_bib53","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1085\/jgp.200810154","article-title":"Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site","volume":"133","author":"Yu","year":"2009","journal-title":"J Gen Physiol"},{"key":"10.2353\/ajpath.2010.090552_bib54","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1038\/35039519","article-title":"Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice","volume":"407","author":"Cockayne","year":"2000","journal-title":"Nature"},{"key":"10.2353\/ajpath.2010.090552_bib55","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1097\/01.ju.0000099660.46774.3c","article-title":"Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis","volume":"171","author":"Sun","year":"2004","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib56","doi-asserted-by":"crossref","first-page":"C27","DOI":"10.1152\/ajpcell.00552.2004","article-title":"Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis","volume":"290","author":"Sun","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.2353\/ajpath.2010.090552_bib57","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.2174\/138161207782341277","article-title":"Purinergic (P2) receptor control of lower genitourinary tract function and new avenues for drug action: an overview","volume":"13","author":"Gur","year":"2007","journal-title":"Curr Pharm Des"},{"key":"10.2353\/ajpath.2010.090552_bib58","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0090-4295(02)01819-8","article-title":"Differential gene expression of cholinergic muscarinic receptor subtypes in male and female normal human urinary bladder","volume":"60","author":"Sigala","year":"2002","journal-title":"Urology"},{"key":"10.2353\/ajpath.2010.090552_bib59","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.juro.2008.11.078","article-title":"Differential expression of functional cannabinoid receptors in human bladder detrusor and urothelium","volume":"181","author":"Tyagi","year":"2009","journal-title":"J Urol"},{"key":"10.2353\/ajpath.2010.090552_bib60","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/sj.bjp.0706976","article-title":"Characterization of kinin receptors in human cultured detrusor smooth muscle cells","volume":"150","author":"Bellucci","year":"2007","journal-title":"Br J Pharmacol"},{"key":"10.2353\/ajpath.2010.090552_bib61","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.npep.2007.05.002","article-title":"Substance P receptor expression in patients with inflammatory bowel disease. Determination by three different techniques, ie, storage phosphor autoradiography, RT-PCR and immunohistochemistry","volume":"41","author":"ter Beek","year":"2007","journal-title":"Neuropeptides"},{"key":"10.2353\/ajpath.2010.090552_bib62","first-page":"L309","article-title":"Substance P (NK1)- and neurokinin A (NK2)-receptor gene expression in inflammatory airway diseases","volume":"269","author":"Bai","year":"1995","journal-title":"Am J Physiol"},{"key":"10.2353\/ajpath.2010.090552_bib63","doi-asserted-by":"crossref","first-page":"27773","DOI":"10.1074\/jbc.M603369200","article-title":"Ubiquitin-dependent down-regulation of the neurokinin-1 receptor","volume":"281","author":"Cottrell","year":"2006","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090552_bib64","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/abio.1996.0166","article-title":"Measurement of intracellular calcium in cell populations loaded with aequorin: neurokinin-1 responses in U373MG cells","volume":"236","author":"Hedley","year":"1996","journal-title":"Anal Biochem"},{"key":"10.2353\/ajpath.2010.090552_bib65","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.urolonc.2007.01.019","article-title":"Micro-RNA profiling in kidney and bladder cancers","volume":"25","author":"Gottardo","year":"2007","journal-title":"Urol Oncol"},{"key":"10.2353\/ajpath.2010.090552_bib66","first-page":"25","article-title":"Clinical experience with substance P receptor (NK1) antagonists in depression","volume":"11","author":"Ranga","year":"2002","journal-title":"J Clin Psychiatry"},{"key":"10.2353\/ajpath.2010.090552_bib67","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2174\/138945006778019282","article-title":"Tachykinins and their receptors in human malignancies","volume":"7","author":"Palma","year":"2006","journal-title":"Curr Drug Target"},{"key":"10.2353\/ajpath.2010.090552_bib68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1159\/000051450","article-title":"Pathophysiology of pancreatitis. Role of cytokines and other mediators of inflammation","volume":"1","author":"Saluja","year":"1999","journal-title":"Digestion, 60 Suppl"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401060346X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000294401060346X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:00:56Z","timestamp":1757599256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000294401060346X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["S000294401060346X"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2010.090552","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2010,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MicroRNAs May Mediate the Down-Regulation of Neurokinin-1 Receptor in Chronic Bladder Pain Syndrome","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2010.090552","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}