{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:24:53Z","timestamp":1790893493509,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3394,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK081943"],"award-info":[{"award-number":["P30DK081943"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U54DA021519"],"award-info":[{"award-number":["U54DA021519"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001353","name":"National Kidney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.2353\/ajpath.2010.090746","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T00:16:26Z","timestamp":1284682586000},"page":"1674-1686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["A Molecular Profile of Focal Segmental Glomerulosclerosis from Formalin-Fixed, Paraffin-Embedded Tissue"],"prefix":"10.1016","volume":"177","author":[{"given":"Jeffrey B.","family":"Hodgin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain C.","family":"Borczuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samih H.","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen S.","family":"Markowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viji","family":"Nair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Eichinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtenay","family":"Vining","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine C.","family":"Berthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kretzler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivette D.","family":"D'Agati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2010.090746_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1053\/j.ajkd.2003.10.024","article-title":"Pathologic classification of focal segmental glomerulosclerosis: a working proposal","volume":"43","author":"D'Agati","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.2353\/ajpath.2010.090746_bib2","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1681\/ASN.V971333","article-title":"Primary focal segmental glomerulosclerosis","volume":"9","author":"Korbet","year":"1998","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib3","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1038\/sj.ki.5001903","article-title":"Cellular focal segmental glomerulosclerosis: clinical and pathologic features","volume":"70","author":"Stokes","year":"2006","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib4","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/sj.ki.5000160","article-title":"Clinical and pathologic characteristics of focal segmental glomerulosclerosis pathologic variants","volume":"69","author":"Thomas","year":"2006","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/MNH.0b013e3282f94a96","article-title":"The spectrum of focal segmental glomerulosclerosis: new insights","volume":"17","author":"D'Agati","year":"2008","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.2353\/ajpath.2010.090746_bib6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1681\/ASN.V10151","article-title":"The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy","volume":"10","author":"Barisoni","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1523-1755.1998.00044.x","article-title":"Progression of glomerular diseases: is the podocyte the culprit?","volume":"54","author":"Kriz","year":"1998","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib8","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/sj.ki.5002655","article-title":"Podocyte injury in focal segmental glomerulosclerosis: lessons from animal models (a play in five acts)","volume":"73","author":"D'Agati","year":"2008","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib9","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1172\/JCI200419139","article-title":"Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli","volume":"113","author":"Peterson","year":"2004","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2010.090746_bib10","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1053\/j.ajkd.2003.12.028","article-title":"Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy","volume":"43","author":"Baelde","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.2353\/ajpath.2010.090746_bib11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1210\/en.2005-0641","article-title":"Obesity-related glomerulopathy: insights from gene expression profiles of the glomeruli derived from renal biopsy samples","volume":"147","author":"Wu","year":"2006","journal-title":"Endocrinology"},{"key":"10.2353\/ajpath.2010.090746_bib12","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1159\/000106775","article-title":"Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli","volume":"107","author":"Bennett","year":"2007","journal-title":"Nephron Exp Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib13","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1093\/nar\/27.22.4436","article-title":"Analysis of chemical modification of RNA from formalin-fixed samples and optimization of molecular biology applications for such samples","volume":"27","author":"Masuda","year":"1999","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090746_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2353\/jmoldx.2007.060004","article-title":"Successful application of microarray technology to microdissected formalin-fixed, paraffin-embedded tissue","volume":"9","author":"Coudry","year":"2007","journal-title":"J Mol Diagn"},{"key":"10.2353\/ajpath.2010.090746_bib15","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090746_bib16","doi-asserted-by":"crossref","first-page":"e2937","DOI":"10.1371\/journal.pone.0002937","article-title":"Improved elucidation of biological processes linked to diabetic nephropathy by single probe-based microarray data analysis","volume":"3","author":"Cohen","year":"2008","journal-title":"PLoS One"},{"key":"10.2353\/ajpath.2010.090746_bib17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2337\/db08-1328","article-title":"Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy","volume":"58","author":"Berthier","year":"2009","journal-title":"Diabetes"},{"key":"10.2353\/ajpath.2010.090746_bib18","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1093\/nar\/gki230","article-title":"Linking disease-associated genes to regulatory networks via promoter organization","volume":"33","author":"Dohr","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090746_bib19","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1056\/NEJMoa0804525","article-title":"Gene expression in fixed tissues and outcome in hepatocellular carcinoma","volume":"359","author":"Hoshida","year":"2008","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2010.090746_bib20","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2337\/diabetes.52.4.1023","article-title":"Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin II","volume":"52","author":"Doublier","year":"2003","journal-title":"Diabetes"},{"key":"10.2353\/ajpath.2010.090746_bib21","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1046\/j.1523-1755.2003.00303.x","article-title":"In situ evaluation of podocin in normal and glomerular diseases","volume":"64","author":"Horinouchi","year":"2003","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1681\/ASN.2008070795","article-title":"Recruitment of podocytes from glomerular parietal epithelial cells","volume":"20","author":"Appel","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib23","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1681\/ASN.2008070709","article-title":"Regeneration of glomerular podocytes by human renal progenitors","volume":"20","author":"Ronconi","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib24","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/path.2051","article-title":"Lessons from studies on focal segmental glomerulosclerosis: an important role for parietal epithelial cells?","volume":"210","author":"Smeets","year":"2006","journal-title":"J Pathol"},{"key":"10.2353\/ajpath.2010.090746_bib25","first-page":"463","article-title":"Pax2 in development and renal disease","volume":"43","author":"Dressler","year":"1999","journal-title":"Int J Dev Biol"},{"key":"10.2353\/ajpath.2010.090746_bib26","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.cub.2006.02.072","article-title":"An inducible mouse model for PAX2-dependent glomerular disease: insights into a complex pathogenesis","volume":"16","author":"Wagner","year":"2006","journal-title":"Curr Biol"},{"key":"10.2353\/ajpath.2010.090746_bib27","doi-asserted-by":"crossref","first-page":"14063","DOI":"10.1074\/jbc.M707390200","article-title":"Ectopic SOX9 mediates extracellular matrix deposition characteristic of organ fibrosis","volume":"283","author":"Hanley","year":"2008","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090746_bib28","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.2353\/ajpath.2007.060899","article-title":"SRY-related HMG box 9 regulates the expression of Col4a2 through transactivating its enhancer element in mesangial cells","volume":"170","author":"Sumi","year":"2007","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2010.090746_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/dbio.2002.0751","article-title":"The mouse Kreisler (Krml1\/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells","volume":"249","author":"Sadl","year":"2002","journal-title":"Dev Biol"},{"key":"10.2353\/ajpath.2010.090746_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/74166","article-title":"NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome","volume":"24","author":"Boute","year":"2000","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2010.090746_bib31","doi-asserted-by":"crossref","unstructured":"Brown EJ, Schlondorff JS, Becker DJ, Tsukaguchi H, Uscinski AL, Higgs HN, Henderson JM, Pollak MR: Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nat Genet 42:72\u201376","DOI":"10.1038\/ng.505"},{"key":"10.2353\/ajpath.2010.090746_bib32","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/ng1918","article-title":"Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible","volume":"38","author":"Hinkes","year":"2006","journal-title":"Nat Genet"},{"key":"10.2353\/ajpath.2010.090746_bib33","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/ki.1994.171","article-title":"IL-8 production by peripheral blood mononuclear cells in nephrotic patients","volume":"45","author":"Garin","year":"1994","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib34","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.180.3.1135","article-title":"Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis","volume":"180","author":"Wada","year":"1994","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.090746_bib35","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.4049\/jimmunol.168.12.6244","article-title":"Expression of functional CCR and CXCR chemokine receptors in podocytes","volume":"168","author":"Huber","year":"2002","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.090746_bib36","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1097\/00007890-200010150-00021","article-title":"Increased nuclear factor-\u03baB and angiotensinogen gene expression in posttransplant recurrent focal segmental glomerulosclerosis","volume":"70","author":"Schachter","year":"2000","journal-title":"Transplantation"},{"key":"10.2353\/ajpath.2010.090746_bib37","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/ATVBAHA.107.144824","article-title":"Osteopontin: a multifunctional molecule regulating chronic inflammation and vascular disease","volume":"27","author":"Scatena","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.2353\/ajpath.2010.090746_bib38","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.tcb.2005.12.005","article-title":"Osteopontin: role in cell signaling and cancer progression","volume":"16","author":"Rangaswami","year":"2006","journal-title":"Trends Cell Biol"},{"key":"10.2353\/ajpath.2010.090746_bib39","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1681\/ASN.2007040486","article-title":"The role of osteopontin in the development of albuminuria","volume":"19","author":"Lorenzen","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib40","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1038\/sj.ki.5000410","article-title":"The podocyte's response to injury: role in proteinuria and glomerulosclerosis","volume":"69","author":"Shankland","year":"2006","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib41","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1681\/ASN.V1081633","article-title":"Directed membrane transport is involved in process formation in cultured podocytes","volume":"10","author":"Simons","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1159\/000058343","article-title":"Retinoic acid regulation of mesangial cell apoptosis","volume":"10","author":"Xu","year":"2002","journal-title":"Exp Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib43","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1111\/j.1745-7254.2008.00849.x","article-title":"All-trans retinoic acid inhibits the increases in fibronectin and PAI-1 induced by TGF-\u03b21 and Ang II in rat mesangial cells","volume":"29","author":"Liu","year":"2008","journal-title":"Acta Pharmacol Sin"},{"key":"10.2353\/ajpath.2010.090746_bib44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1681\/ASN.2006070727","article-title":"Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway","volume":"18","author":"He","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.090746_bib45","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0272-6386(12)80333-7","article-title":"The Egr family of nuclear signal transducers","volume":"17","author":"Sukhatme","year":"1991","journal-title":"Am J Kidney Dis"},{"key":"10.2353\/ajpath.2010.090746_bib46","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1038\/sj.ki.5001941","article-title":"Expression of allograft inflammatory factor-1 in kidneys: a novel molecular component of podocyte","volume":"70","author":"Tsubata","year":"2006","journal-title":"Kidney Int"},{"key":"10.2353\/ajpath.2010.090746_bib47","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1161\/01.RES.0000074000.03562.CC","article-title":"AIF-1 is an actin-polymerizing and Rac1-activating protein that promotes vascular smooth muscle cell migration","volume":"92","author":"Autieri","year":"2003","journal-title":"Circ Res"},{"key":"10.2353\/ajpath.2010.090746_bib48","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1242\/dev.108.2.313","article-title":"Early expression of desmosomal components during kidney tubule morphogenesis in human and murine embryos","volume":"108","author":"Garrod","year":"1990","journal-title":"Development"},{"key":"10.2353\/ajpath.2010.090746_bib49","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1091\/mbc.e07-02-0190","article-title":"The trans-Golgi network accessory protein p56 promotes long-range movement of GGA\/clathrin-containing transport carriers and lysosomal enzyme sorting","volume":"18","author":"Mardones","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.2353\/ajpath.2010.090746_bib50","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1681\/ASN.2005030278","article-title":"Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout mice","volume":"16","author":"Cui","year":"2005","journal-title":"J Am Soc Nephrol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010602210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010602210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:59:38Z","timestamp":1757599178000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010602210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0002944010602210"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2010.090746","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Molecular Profile of Focal Segmental Glomerulosclerosis from Formalin-Fixed, Paraffin-Embedded Tissue","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2010.090746","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}