{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:32:09Z","timestamp":1790422329983,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3516,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.2353\/ajpath.2010.090780","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T22:17:06Z","timestamp":1271369826000},"page":"2607-2615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers"],"prefix":"10.1016","volume":"176","author":[{"given":"Elodie E.","family":"Noel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Yeste-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakunthala C.","family":"Kudahetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningfeng F.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swee","family":"Sharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Chaplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Powles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Tim D.","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan D.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Shipley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"Berney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P.","family":"Joel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Jie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2010.090780_bib1","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","article-title":"The resurgence of platinum-based cancer chemotherapy","volume":"7","author":"Kelland","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib2","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1056\/NEJMoa0802656","article-title":"Platinum-based chemotherapy plus cetuximab in head and neck cancer","volume":"359","author":"Vermorken","year":"2008","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2010.090780_bib3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/cncr.21742","article-title":"Recent advances in management of patients with platinum-refractory testicular germ cell tumors","volume":"106","author":"Kollmannsberger","year":"2006","journal-title":"Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib4","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/annonc\/mdg242","article-title":"Towards an understanding of the biological basis of response to cisplatin-based chemotherapy in germ-cell tumors","volume":"14","author":"Mayer","year":"2003","journal-title":"Ann Oncol"},{"key":"10.2353\/ajpath.2010.090780_bib5","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.4161\/cc.7.10.5930","article-title":"How do real tumors become resistant to cisplatin?","volume":"7","author":"Borst","year":"2008","journal-title":"Cell Cycle"},{"key":"10.2353\/ajpath.2010.090780_bib6","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1200\/JCO.2006.08.4285","article-title":"Biology and genetics of adult male germ cell tumors","volume":"24","author":"Houldsworth","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.2353\/ajpath.2010.090780_bib7","first-page":"767","article-title":"Molecular determinants of treatment response in human germ cell tumors","volume":"9","author":"Mayer","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib8","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrc1120","article-title":"Curing metastatic cancer: lessons from testicular germ-cell tumours","volume":"3","author":"Masters","year":"2003","journal-title":"Nat Rev Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1034\/j.1600-0463.2003.11101201.x","article-title":"Role of gain of 12p in germ cell tumour development","volume":"111","author":"Looijenga","year":"2003","journal-title":"Apmis"},{"key":"10.2353\/ajpath.2010.090780_bib10","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1038\/sj.onc.1201770","article-title":"Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation","volume":"16","author":"Houldsworth","year":"1998","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090780_bib11","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1200\/JCO.2002.20.6.1551","article-title":"Role of P53 and MDM2 in treatment response of human germ cell tumors","volume":"20","author":"Kersemaekers","year":"2002","journal-title":"J Clin Oncol"},{"key":"10.2353\/ajpath.2010.090780_bib12","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1158\/1078-0432.CCR-07-2238","article-title":"Platinum resistance: the role of DNA repair pathways","volume":"14","author":"Martin","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib13","first-page":"2758","article-title":"Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment","volume":"62","author":"Mayer","year":"2002","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib14","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/ijc.23291","article-title":"Mismatch repair expression in testicular cancer predicts recurrence and survival","volume":"122","author":"Velasco","year":"2008","journal-title":"Int J Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib15","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/1471-2407-6-201","article-title":"Mismatch repair and treatment resistance in ovarian cancer","volume":"6","author":"Helleman","year":"2006","journal-title":"BMC Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib16","first-page":"4319","article-title":"Influence of hMLH1 methylation, mismatch repair deficiency and microsatellite instability on chemoresistance of testicular germ-cell tumors","volume":"25","author":"Olasz","year":"2005","journal-title":"Anticancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib17","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1200\/JCO.2008.18.8623","article-title":"Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors","volume":"27","author":"Honecker","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.2353\/ajpath.2010.090780_bib18","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/path.2622","article-title":"Seladin-1 and testicular germ cell tumours: new insights into cisplatin responsiveness","volume":"219","author":"Nuti","year":"2009","journal-title":"J Pathol"},{"key":"10.2353\/ajpath.2010.090780_bib19","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/bjc.1989.108","article-title":"Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes","volume":"59","author":"Hills","year":"1989","journal-title":"Br J Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib20","first-page":"2110","article-title":"Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine","volume":"45","author":"Louie","year":"1985","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/ijc.2910450306","article-title":"Metallothionein gene expression and resistance to cisplatin in human ovarian cancer","volume":"45","author":"Schilder","year":"1990","journal-title":"Int J Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/gcc.20564","article-title":"Identification of genomic changes associated with cisplatin resistance in testicular germ cell tumor cell lines","volume":"47","author":"Noel","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib23","doi-asserted-by":"crossref","first-page":"9137","DOI":"10.1158\/0008-5472.CAN-05-1697","article-title":"Association between large-scale genomic homozygosity without chromosomal loss and nonseminomatous germ cell tumor development","volume":"65","author":"Lu","year":"2005","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/gcc.20452","article-title":"Rapid high-resolution karyotyping with precise identification of chromosome breakpoints","volume":"46","author":"Mao","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/(SICI)1098-2264(199711)20:3<275::AID-GCC8>3.0.CO;2-#","article-title":"Phyllodes tumors of the breast analyzed by comparative genomic hybridization and association of increased 1q copy number with stromal overgrowth and recurrence","volume":"20","author":"Lu","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib26","doi-asserted-by":"crossref","first-page":"9197","DOI":"10.1073\/pnas.161272798","article-title":"Comparative expressed sequence hybridization to chromosomes for tumor classification and identification of genomic regions of differential gene expression","volume":"98","author":"Lu","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090780_bib27","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.neuroscience.2009.01.035","article-title":"Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation-induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry","volume":"159","author":"Yeste-Velasco","year":"2009","journal-title":"Neuroscience"},{"key":"10.2353\/ajpath.2010.090780_bib28","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00280-009-0944-6","article-title":"The relative activity of cisplatin, oxaliplatin and satraplatin in testicular germ cell tumour sensitive and resistant cell lines","volume":"64","author":"Perry","year":"2009","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.2353\/ajpath.2010.090780_bib29","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2407-6-224","article-title":"Identification of genes associated with cisplatin resistance in human oral squamous cell carcinoma cell line","volume":"6","author":"Zhang","year":"2006","journal-title":"BMC Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/02841860600547380","article-title":"p53 mutation and cyclin D1 amplification correlate with cisplatin sensitivity in xenografted human squamous cell carcinomas from head and neck","volume":"45","author":"Henriksson","year":"2006","journal-title":"Acta Oncol"},{"key":"10.2353\/ajpath.2010.090780_bib31","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1158\/1078-0432.CCR-04-2419","article-title":"Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell line","volume":"11","author":"Biliran","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/(SICI)1097-0215(19960717)67:2<224::AID-IJC13>3.0.CO;2-B","article-title":"Sensitivity to cis-diamminedichloroplatinum in human cancer cells is related to expression of cyclin D1 but not c-raf-1 protein","volume":"67","author":"Warenius","year":"1996","journal-title":"Int J Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-6-24","article-title":"The regulation of cyclin D1 degradation: roles in cancer development and the potential for therapeutic invention","volume":"6","author":"Alao","year":"2007","journal-title":"Mol Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib34","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1038\/sj.onc.1210506","article-title":"Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer","volume":"26","author":"Bostner","year":"2007","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090780_bib35","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1002\/cncr.21491","article-title":"Cyclin D1 gene numerical aberration is a predictive marker for occult cervical lymph node metastasis in TNM stage I and II squamous cell carcinoma of the oral cavity","volume":"104","author":"Myo","year":"2005","journal-title":"Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib36","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1097\/00005537-200106000-00010","article-title":"Antisense cyclin D1 enhances sensitivity of head and neck cancer cells to cisplatin","volume":"111","author":"Wang","year":"2001","journal-title":"Laryngoscope"},{"key":"10.2353\/ajpath.2010.090780_bib37","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/ijc.23964","article-title":"Inhibition of cyclin D1 expression by cyclin D1 shRNAs in human oral squamous cell carcinoma cells is associated with increased cisplatin chemosensitivity","volume":"124","author":"Zhou","year":"2009","journal-title":"Int J Cancer"},{"key":"10.2353\/ajpath.2010.090780_bib38","first-page":"4876","article-title":"Antisense cyclin D1 induces apoptosis and tumor shrinkage in human squamous carcinomas","volume":"59","author":"Sauter","year":"1999","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090780_bib39","doi-asserted-by":"crossref","first-page":"6738","DOI":"10.1038\/onc.2008.265","article-title":"Cyclin D1 in low-dose radiation-induced adaptive resistance","volume":"27","author":"Ahmed","year":"2008","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090780_bib40","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1172\/JCI1323","article-title":"Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinum","volume":"101","author":"Kornmann","year":"1998","journal-title":"J Clin Invest"},{"key":"10.2353\/ajpath.2010.090780_bib41","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1001\/archotol.126.8.957","article-title":"Antisense inhibition of cyclin D1 in human head and neck squamous cell carcinoma","volume":"126","author":"Nakashima","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.2353\/ajpath.2010.090780_bib42","doi-asserted-by":"crossref","first-page":"318","DOI":"10.4161\/cbt.4.3.1504","article-title":"Growth inhibition of head and neck squamous carcinoma cells by small interfering RNAs targeting eIF4E or cyclin D1 alone or combined with cisplatin","volume":"4","author":"Oridate","year":"2005","journal-title":"Cancer Biol Ther"},{"key":"10.2353\/ajpath.2010.090780_bib43","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.3748\/wjg.v12.i11.1766","article-title":"Cyclin D1 antisense oligodexoyneucleotides inhibits growth and enhances chemosensitivity in gastric carcinoma cells","volume":"12","author":"Shuai","year":"2006","journal-title":"World J Gastroenterol"},{"key":"10.2353\/ajpath.2010.090780_bib44","first-page":"1397","article-title":"Enhancing cisplatin sensitivity in MCF-7 human breast cancer cells by down-regulation of Bcl-2 and cyclin D1","volume":"29","author":"Yde","year":"2006","journal-title":"Int J Oncol"},{"key":"10.2353\/ajpath.2010.090780_bib45","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.4161\/cc.5.18.3218","article-title":"Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human","volume":"5","author":"Lee","year":"2006","journal-title":"Cell Cycle"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010607845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010607845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:50:23Z","timestamp":1762080623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010607845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S0002944010607845"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2010.090780","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Association of CCND1 Overexpression and Cisplatin Resistance in Testicular Germ Cell Tumors and Other Cancers","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2010.090780","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}