{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:14:16Z","timestamp":1790230456371,"version":"4.1.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3455,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003395","name":"Skin Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\/CA105958"],"award-info":[{"award-number":["R01\/CA105958"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006379","name":"Office of Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006379","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007217","name":"Health Services Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007217","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["1 RO1 ES 8061"],"award-info":[{"award-number":["1 RO1 ES 8061"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P01 AR050440-01"],"award-info":[{"award-number":["P01 AR050440-01"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.2353\/ajpath.2010.090925","type":"journal-article","created":{"date-parts":[[2010,7,8]],"date-time":"2010-07-08T23:05:40Z","timestamp":1278630340000},"page":"555-562","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["The DNA Damage-Binding Protein XPC Is a Frequent Target for Inactivation in Squamous Cell Carcinomas"],"prefix":"10.1016","volume":"177","author":[{"given":"Sebastien","family":"de Feraudy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Ridd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren M.","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui-Yan","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Revet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luzviminda","family":"Feeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Cleaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2010.090925_bib1","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJM200103293441306","article-title":"Cutaneous squamous-cell carcinoma","volume":"344","author":"Alam","year":"2001","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2010.090925_bib2","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1056\/NEJMra044151","article-title":"Basal-cell carcinoma","volume":"353","author":"Rubin","year":"2005","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2010.090925_bib3","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1470-2045(08)70178-5","article-title":"Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study","volume":"9","author":"Brantsch","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.2353\/ajpath.2010.090925_bib4","first-page":"228","article-title":"p53 mutations in human aggressive and nonaggressive basal and squamous cell carcinomas","volume":"9","author":"Bolshakov","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090925_bib5","doi-asserted-by":"crossref","first-page":"621","DOI":"10.4161\/cc.3.5.860","article-title":"Pathways sufficient to induce epidermal carcinogenesis","volume":"3","author":"Ridky","year":"2004","journal-title":"Cell Cycle"},{"key":"10.2353\/ajpath.2010.090925_bib6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1600-0560.2007.00807.x","article-title":"Activation of Src-family tyrosine kinases in hyperproliferative epidermal disorders","volume":"35","author":"Ayli","year":"2008","journal-title":"J Cutan Pathol"},{"key":"10.2353\/ajpath.2010.090925_bib7","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/218652a0","article-title":"Defective repair replication in xeroderma pigmentosum","volume":"218","author":"Cleaver","year":"1968","journal-title":"Nature"},{"key":"10.2353\/ajpath.2010.090925_bib8","series-title":"The Genetic Basis of Human Cancer","first-page":"245","article-title":"Nucleotide excision repair syndromes: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy","author":"Bootsma","year":"1998"},{"key":"10.2353\/ajpath.2010.090925_bib9","first-page":"d1024","article-title":"UV damage. DNA repair and skin carcinogenesis","volume":"7","author":"Cleaver","year":"2002","journal-title":"Front Biosci"},{"key":"10.2353\/ajpath.2010.090925_bib10","first-page":"335","article-title":"Nucleotide excision repair: Its relation to human disease","volume":"Vol. 2","author":"Thompson","year":"1998"},{"key":"10.2353\/ajpath.2010.090925_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1001\/archderm.1987.01660260111026","article-title":"Xeroderma pigmentosum: cutaneous, ocular and neurological abnormalities in 830 published cases","volume":"123","author":"Kraemer","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.2353\/ajpath.2010.090925_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"},{"key":"10.2353\/ajpath.2010.090925_bib13","doi-asserted-by":"crossref","first-page":"10124","DOI":"10.1073\/pnas.88.22.10124","article-title":"A role for sunlight in skin cancer: uV-induced p53 mutations in squamous cell carcinoma","volume":"88","author":"Brash","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090925_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1751-1097.1995.tb05262.x","article-title":"p53 gene mutations and photocarcinogenesis","volume":"62","author":"Nataraj","year":"1995","journal-title":"Photochem Photobiol"},{"key":"10.2353\/ajpath.2010.090925_bib15","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1073\/pnas.90.22.10529","article-title":"Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients","volume":"90","author":"Dumaz","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090925_bib16","article-title":"The biology of xeroderma pigmentosum: lessons learned to explain the development of melanoma","volume":"Vol. 16","author":"Cleaver","year":"2005"},{"key":"10.2353\/ajpath.2010.090925_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/DAD.0b013e3181af0a5e","article-title":"Diagnosing xeroderma pigmentosum group C by immunohistochemistry","volume":"32","author":"de Feraudy","year":"2010","journal-title":"Am J Dermatopath"},{"key":"10.2353\/ajpath.2010.090925_bib18","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.1038\/sj.onc.1206621","article-title":"Genome-wide-array-based comparative genomic hybridization reveals genetic homogeneity and frequent copy number increases encompassing CCNE1 in fallopian tube carcinoma","volume":"22","author":"Snijders","year":"2003","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090925_bib19","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1056\/NEJMoa050092","article-title":"Distinct sets of genetic alterations in melanoma","volume":"353","author":"Curtin","year":"2005","journal-title":"N Engl J Med"},{"key":"10.2353\/ajpath.2010.090925_bib20","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/gb-2007-8-6-r120","article-title":"Genome position and gene amplification","volume":"8","author":"Gajduskova","year":"2007","journal-title":"Genome Biol"},{"key":"10.2353\/ajpath.2010.090925_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/biostatistics\/kxh008","article-title":"Circular binary segmentation for the analysis of array-based DNA copy number data","volume":"5","author":"Olshen","year":"2004","journal-title":"Biostatistics"},{"key":"10.2353\/ajpath.2010.090925_bib22","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1093\/bioinformatics\/bti677","article-title":"A comparison study: applying segmentation to array CGH data for downstream analyses","volume":"21","author":"Willenbrock","year":"2005","journal-title":"Bioinformatics"},{"key":"10.2353\/ajpath.2010.090925_bib23","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/sj.jid.5700555","article-title":"Xeroderma pigmentosum group C in an isolated region of Guatemala","volume":"127","author":"Cleaver","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2010.090925_bib24","first-page":"1102","article-title":"Increased UV sensitivity and chromosomal instability related to p53 function in the xeroderma pigmentosum variant","volume":"59","author":"Cleaver","year":"1999","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090925_bib25","first-page":"73S","article-title":"Role of p53 in the mammalian cellular response to UV damage","volume":"67","author":"Ford","year":"1998","journal-title":"Photochem Photobiol"},{"key":"10.2353\/ajpath.2010.090925_bib26","doi-asserted-by":"crossref","first-page":"7395","DOI":"10.1038\/sj.onc.1203147","article-title":"Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associated with the increased susceptibility of mice lacking the XPC gene to UV carcinogenesis","volume":"18","author":"Ananthaswamy","year":"1999","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090925_bib27","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.ejcb.2006.11.002","article-title":"The multi-step process of human skin carcinogenesis: a role for p53, cyclin D1, hTERT, p16, and TSP-1","volume":"86","author":"Burnworth","year":"2007","journal-title":"Eur J Cell Biol"},{"key":"10.2353\/ajpath.2010.090925_bib28","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1038\/sj.jid.5700375","article-title":"Are keratoacanthomas variants of squamous cell carcinomas? A comparison of chromosomal aberrations by comparative genomic hybridization","volume":"126","author":"Clausen","year":"2006","journal-title":"J Invest Dermatol"},{"key":"10.2353\/ajpath.2010.090925_bib29","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.dnarep.2007.07.005","article-title":"p53 suppression overwhelms DNA polymerase h deficiency in determining the cellular UV DNA damage response","volume":"6","author":"Laposa","year":"2007","journal-title":"DNA Repair"},{"key":"10.2353\/ajpath.2010.090925_bib30","doi-asserted-by":"crossref","first-page":"28073","DOI":"10.1074\/jbc.272.44.28073","article-title":"Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts","volume":"272","author":"Ford","year":"1997","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090925_bib31","doi-asserted-by":"crossref","first-page":"8876","DOI":"10.1073\/pnas.92.19.8876","article-title":"Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance","volume":"92","author":"Ford","year":"1995","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090925_bib32","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.1158\/1078-0432.CCR-07-0407","article-title":"Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a\/ARF","volume":"13","author":"Bean","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090925_bib33","first-page":"4402","article-title":"p53 mutations in skin and internal tumors of xeroderma pigmentosum patients belonging to the complementation group C","volume":"58","author":"Giglia","year":"1998","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090925_bib34","first-page":"2480","article-title":"Association between DNA repair-deficiency and high level of p53 mutations in melanoma of xeroderma pigmentosum","volume":"61","author":"Spatz","year":"2001","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090925_bib35","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/carcin\/bgi055","article-title":"Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study","volume":"26","author":"Blankenburg","year":"2005","journal-title":"Carcinogen"},{"key":"10.2353\/ajpath.2010.090925_bib36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.ejhg.5201296","article-title":"No association between three xeroderma pigmentosum group C and one group G gene polymorphisms and risk of cutaneous melanoma","volume":"13","author":"Blankenburg","year":"2005","journal-title":"Eur J Hum Genet"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010601137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010601137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:58:55Z","timestamp":1757599135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010601137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0002944010601137"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2010.090925","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The DNA Damage-Binding Protein XPC Is a Frequent Target for Inactivation in Squamous Cell Carcinomas","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2010.090925","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}