{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:08:48Z","timestamp":1791410928218,"version":"4.3.3"},"reference-count":62,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3577,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.2353\/ajpath.2010.090950","type":"journal-article","created":{"date-parts":[[2010,2,4]],"date-time":"2010-02-04T22:35:01Z","timestamp":1265322901000},"page":"1878-1890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"title":["Novel Proteins Regulated by mTOR in Subependymal Giant Cell Astrocytomas of Patients with Tuberous Sclerosis Complex and New Therapeutic Implications"],"prefix":"10.1016","volume":"176","author":[{"given":"Magdalena Ewa","family":"Tyburczy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kotulska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Pokarowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Mieczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Kucharska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieslawa","family":"Grajkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Roszkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergiusz","family":"Jozwiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Kaminska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2010.090950_bib1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF00315012","article-title":"Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: an immunohistochemical, ultrastructural, and immunoelectron and microscopic study","volume":"90","author":"Hirose","year":"1995","journal-title":"Acta Neuropathol"},{"key":"10.2353\/ajpath.2010.090950_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1440-1789.2008.00934.x","article-title":"Subependymal giant cell astrocytoma (SEGA): Is it an astrocytoma? Morphological, immunohistochemical and ultrastructural study","volume":"29","author":"Buccoliero","year":"2009","journal-title":"Neuropathology"},{"key":"10.2353\/ajpath.2010.090950_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1010664311717","article-title":"Biological behavior and tumorigenesis of subependymal giant cell astrocytomas","volume":"52","author":"Kim","year":"2001","journal-title":"J Neurooncol"},{"key":"10.2353\/ajpath.2010.090950_bib4","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1177\/088307380001501003","article-title":"Usefulness of diagnostic criteria of tuberous sclerosis complex in pediatric patients","volume":"15","author":"Jozwiak","year":"2000","journal-title":"J Child Neurol"},{"key":"10.2353\/ajpath.2010.090950_bib5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/archneur.55.3.379","article-title":"Poor mental development in patients with tuberous sclerosis complex: clinical risk factors","volume":"55","author":"Jozwiak","year":"1998","journal-title":"Arch Neurol"},{"key":"10.2353\/ajpath.2010.090950_bib6","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","article-title":"Identification and characterization of the tuberous sclerosis gene on chromosome 16","volume":"75","author":"European Chromosome 16 Tuberous Sclerosis Consortium","year":"1993","journal-title":"Cell"},{"key":"10.2353\/ajpath.2010.090950_bib7","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.277.5327.805","article-title":"Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34","volume":"277","author":"van Slegtenhorst","year":"1997","journal-title":"Science"},{"key":"10.2353\/ajpath.2010.090950_bib8","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1038\/sj.onc.1204009","article-title":"The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination","volume":"19","author":"Benvenuto","year":"2000","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090950_bib9","doi-asserted-by":"crossref","first-page":"8313","DOI":"10.1074\/jbc.C500451200","article-title":"TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase","volume":"281","author":"Chong-Kopera","year":"2006","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090950_bib10","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/ncb999","article-title":"Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins","volume":"5","author":"Zhang","year":"2003","journal-title":"Nat Cell Biol"},{"key":"10.2353\/ajpath.2010.090950_bib11","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1073\/pnas.95.4.1432","article-title":"RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1","volume":"95","author":"Burnett","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090950_bib12","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/sj.onc.1207542","article-title":"Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression","volume":"23","author":"Fingar","year":"2004","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090950_bib13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signaling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"key":"10.2353\/ajpath.2010.090950_bib14","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1002\/ana.20784","article-title":"Rapamycin causes regression of astrocytomas in tuberous sclerosis complex","volume":"59","author":"Franz","year":"2006","journal-title":"Ann Neurol"},{"key":"10.2353\/ajpath.2010.090950_bib15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1042\/BST0370259","article-title":"Therapeutic targeting of mTOR in tuberous sclerosis","volume":"37","author":"Sampson","year":"2009","journal-title":"Biochem Soc Trans"},{"key":"10.2353\/ajpath.2010.090950_bib16","doi-asserted-by":"crossref","first-page":"14866","DOI":"10.1073\/pnas.96.26.14866","article-title":"Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins","volume":"96","author":"Hardwick","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090950_bib17","doi-asserted-by":"crossref","first-page":"13227","DOI":"10.1073\/pnas.240444197","article-title":"A chemical genomics approach toward understanding the global functions of the target of rapamycin protein (TOR)","volume":"97","author":"Chan","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090950_bib18","doi-asserted-by":"crossref","first-page":"7215","DOI":"10.1073\/pnas.0500297102","article-title":"Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method","volume":"102","author":"Xie","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.090950_bib19","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.cub.2006.03.084","article-title":"Functional genomics identifies TOR-regulated genes that control growth and division","volume":"16","author":"Guertin","year":"2006","journal-title":"Curr Biol"},{"key":"10.2353\/ajpath.2010.090950_bib20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1006\/mcne.2002.1184","article-title":"Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway","volume":"21","author":"Onda","year":"2002","journal-title":"Mol Cell Neurosci"},{"key":"10.2353\/ajpath.2010.090950_bib21","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/gng015","article-title":"Summaries of Affymetrix GeneChip probe level data","volume":"31","author":"Irizarry","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/ajpath.2010.090950_bib22","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nbt0604-656b","article-title":"Preprocessing of oligonucleotide array data","volume":"22","author":"Wu","year":"2004","journal-title":"Nature Biotechnol"},{"key":"10.2353\/ajpath.2010.090950_bib23","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-2-8-research0032","article-title":"Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application","volume":"2","author":"Li","year":"2001","journal-title":"Genome Biol"},{"key":"10.2353\/ajpath.2010.090950_bib24","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/nbt836","article-title":"A model of molecular interactions on short oligonucleotide microarrays","volume":"21","author":"Zhang","year":"2003","journal-title":"Nature Biotechnol"},{"key":"10.2353\/ajpath.2010.090950_bib25","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.2353\/ajpath.2010.090950_bib26","doi-asserted-by":"crossref","first-page":"7617","DOI":"10.1038\/sj.onc.1207137","article-title":"Inhibition of Akt kinase signalling and activation of Forkhead are indispensable for upregulation of FasL expression in apoptosis of glioma cells","volume":"22","author":"Ciechomska","year":"2003","journal-title":"Oncogene"},{"key":"10.2353\/ajpath.2010.090950_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02685886","article-title":"Brain tumor formation in tuberous sclerosis depends on Erk activation","volume":"9","author":"Jozwiak","year":"2007","journal-title":"Neuromolecular Med"},{"key":"10.2353\/ajpath.2010.090950_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1470-2045(07)70411-4","article-title":"Possible mechanisms of disease development in tuberous sclerosis","volume":"9","author":"Jozwiak","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.2353\/ajpath.2010.090950_bib29","first-page":"3469","article-title":"Tuberous sclerosis-associated neoplasms express activated p42\/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth","volume":"9","author":"Govindarajan","year":"2003","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090950_bib30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.137.2.481","article-title":"Regulation of cell motility by mitogen-activated protein kinase","volume":"137","author":"Klemke","year":"1997","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2010.090950_bib31","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1016\/j.cellsig.2007.04.012","article-title":"Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective","volume":"19","author":"Pullikuth","year":"2007","journal-title":"Cell Signal"},{"key":"10.2353\/ajpath.2010.090950_bib32","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/cncr.23338","article-title":"Identification of survival-related genes of the phosphatidylinositol 3\u2032-kinase signaling pathway in glioblastoma multiforme","volume":"112","author":"Ruano","year":"2008","journal-title":"Cancer"},{"key":"10.2353\/ajpath.2010.090950_bib33","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.3748\/wjg.v10.i10.1466","article-title":"Overexpression of annexin 1 in pancreatic cancer and its clinical significance","volume":"10","author":"Bai","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.2353\/ajpath.2010.090950_bib34","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0002-9440(10)63098-2","article-title":"Annexin A1 down-regulation in head and neck cancer is associated with epithelial differentiation status","volume":"164","author":"Garcia Pedrero","year":"2004","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2010.090950_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbrc.2004.10.214","article-title":"Loss of annexin A1 expression in human breast cancer detected by multiple high-throughput analyses","volume":"326","author":"Shen","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.2353\/ajpath.2010.090950_bib36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1074\/jbc.271.2.719","article-title":"Calcium-dependent binding of S100C to the N-terminal domain of annexin I","volume":"271","author":"Mailliard","year":"1996","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090950_bib37","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1158\/1078-0432.606.11.2","article-title":"Down-regulation of S100C is associated with bladder cancer progression and poor survival","volume":"11","author":"Memon","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090950_bib38","first-page":"31","article-title":"Localization of S100C immunoreactivity in various human tissues","volume":"56","author":"Kondo","year":"2002","journal-title":"Acta Med Okayama"},{"key":"10.2353\/ajpath.2010.090950_bib39","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-2559.2005.02097.x","article-title":"Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: s100A6. S100A8, S100A9 and S100A11 are all overexpressed in common cancers","volume":"46","author":"Cross","year":"2005","journal-title":"Histopathology"},{"key":"10.2353\/ajpath.2010.090950_bib40","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.humpath.2004.07.015","article-title":"Dysregulated expression of S100A11 (calgizzarin) in prostate cancer and precursor lesions","volume":"35","author":"Rehman","year":"2004","journal-title":"Hum Pathol"},{"key":"10.2353\/ajpath.2010.090950_bib41","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1083\/jcb.149.6.1193","article-title":"Relationship between contact inhibition and intranuclear S100C of normal human fibroblasts","volume":"149","author":"Sakaguchi","year":"2000","journal-title":"J Cell Biol"},{"key":"10.2353\/ajpath.2010.090950_bib42","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1158\/1078-0432.CCR-05-2797","article-title":"Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme","volume":"12","author":"Kuan","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.2353\/ajpath.2010.090950_bib43","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1158\/1541-7786.MCR-07-0119","article-title":"Osteoactivin promotes breast cancer metastasis to bone","volume":"5","author":"Rose","year":"2007","journal-title":"Mol Cancer Res"},{"key":"10.2353\/ajpath.2010.090950_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ijc.2910600111","article-title":"nmb, a novel gene, is expressed in low-metastatic human melanoma cell lines and xenografts","volume":"60","author":"Weterman","year":"1995","journal-title":"Int J Cancer"},{"key":"10.2353\/ajpath.2010.090950_bib45","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/373721a0","article-title":"Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA","volume":"373","author":"He","year":"1995","journal-title":"Nature"},{"key":"10.2353\/ajpath.2010.090950_bib46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10143-007-0107-3","article-title":"Candidate genes for the progression of malignant gliomas identified by microarray analysis","volume":"31","author":"Bozinov","year":"2008","journal-title":"Neurosurg Rev"},{"key":"10.2353\/ajpath.2010.090950_bib47","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1002\/ijc.23727","article-title":"Lactotransferrin: a candidate tumor suppressor-Deficient expression in human nasopharyngeal carcinoma and inhibition of NPC cell proliferation by modulating the mitogen-activated protein kinase pathway","volume":"123","author":"Zhou","year":"2008","journal-title":"Int J Cancer"},{"key":"10.2353\/ajpath.2010.090950_bib48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/B:BREA.0000018423.47497.c6","article-title":"Rho proteins and cancer","volume":"84","author":"Ridley","year":"2004","journal-title":"Breast Cancer Res Treat"},{"key":"10.2353\/ajpath.2010.090950_bib49","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.yexcr.2006.11.006","article-title":"RhoE interferes with Rb inactivation and regulates the proliferation and survival of the U87 human glioblastoma cell line","volume":"313","author":"Poch","year":"2007","journal-title":"Exp Cell Res"},{"key":"10.2353\/ajpath.2010.090950_bib50","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/pros.20243","article-title":"Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis","volume":"64","author":"Bektic","year":"2005","journal-title":"Prostate"},{"key":"10.2353\/ajpath.2010.090950_bib51","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1158\/1541-7786.MCR-08-0039","article-title":"Secreted frizzled-related protein 4 regulates two Wnt7a signaling pathways and inhibits proliferation in endometrial cancer cells","volume":"6","author":"Carmon","year":"2008","journal-title":"Mol Cancer Res"},{"key":"10.2353\/ajpath.2010.090950_bib52","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1158\/0008-5472.CAN-05-3712","article-title":"CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia","volume":"66","author":"Liu","year":"2006","journal-title":"Cancer Res"},{"key":"10.2353\/ajpath.2010.090950_bib53","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1523\/JNEUROSCI.4317-05.2006","article-title":"Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology","volume":"26","author":"Brockschnieder","year":"2006","journal-title":"J Neurosci"},{"key":"10.2353\/ajpath.2010.090950_bib54","doi-asserted-by":"crossref","first-page":"17786","DOI":"10.1074\/jbc.M002254200","article-title":"Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2","volume":"275","author":"Kirkpatrick","year":"2000","journal-title":"J Biol Chem"},{"key":"10.2353\/ajpath.2010.090950_bib55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.neuron.2007.06.020","article-title":"Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment","volume":"55","author":"Sia","year":"2007","journal-title":"Neuron"},{"key":"10.2353\/ajpath.2010.090950_bib56","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1471-4159.2007.04605.x","article-title":"NeuroD1: developmental expression and regulated genes in the rodent pineal gland","volume":"102","author":"Munoz","year":"2007","journal-title":"J Neurochem"},{"key":"10.2353\/ajpath.2010.090950_bib57","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1210\/me.2003-0127","article-title":"Tpit-independent function of NeuroD1(BETA2) in pituitary corticotroph differentiation","volume":"18","author":"Lamolet","year":"2004","journal-title":"Mol Endocrinol"},{"key":"10.2353\/ajpath.2010.090950_bib58","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/MCB.19.1.704","article-title":"The NeuroD1\/BETA2 sequences essential for insulin gene transcription colocalize with those necessary for neurogenesis and p300\/CREB binding protein binding","volume":"19","author":"Sharma","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.2353\/ajpath.2010.090950_bib59","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3727\/000000005783992133","article-title":"Transcriptional profile of NeuroD expression in a human fetal astroglial cell line","volume":"12","author":"Kamath","year":"2005","journal-title":"Gene Expr"},{"key":"10.2353\/ajpath.2010.090950_bib60","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1073\/pnas.97.2.865","article-title":"Loss of BETA2\/NeuroD leads to malformation of the dentate gyrus and epilepsy","volume":"97","author":"Liu","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 4","key":"10.2353\/ajpath.2010.090950_bib61","first-page":"383","article-title":"Serum carnosinase deficiency: a non-disabling phenotype?","volume":"29","author":"Cohen","year":"1985","journal-title":"J Ment Defic Res"},{"key":"10.2353\/ajpath.2010.090950_bib62","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/BF00965207","article-title":"Homocarnosinosis: influence of dietary restriction of histidine","volume":"11","author":"Lunde","year":"1986","journal-title":"Neurochem Res"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010605007?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010605007?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:05:31Z","timestamp":1757599531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010605007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0002944010605007"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2010.090950","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel Proteins Regulated by mTOR in Subependymal Giant Cell Astrocytomas of Patients with Tuberous Sclerosis Complex and New Therapeutic Implications","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2010.090950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}