{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:46:53Z","timestamp":1787496413680,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3424,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ajp.amjpathol.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Pathology"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.2353\/ajpath.2010.091106","type":"journal-article","created":{"date-parts":[[2010,7,22]],"date-time":"2010-07-22T23:42:28Z","timestamp":1279842148000},"page":"1265-1273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"title":["Interleukin-17 Promotes Early Allograft Inflammation"],"prefix":"10.1016","volume":"177","author":[{"given":"Victoria","family":"Gorbacheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Valujskikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/ajpath.2010.091106_bib1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.4049\/jimmunol.162.1.352","article-title":"Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice","volume":"162","author":"Benichou","year":"1999","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1084\/jem.174.2.493","article-title":"Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction","volume":"174","author":"Dallman","year":"1991","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.091106_bib3","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/00007890-199304000-00042","article-title":"Alloantigen-dependent endothelial phenotype and lymphokine mRNA expression in rejecting murine cardiac allografts","volume":"55","author":"Morgan","year":"1993","journal-title":"Transplantation"},{"key":"10.2353\/ajpath.2010.091106_bib4","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.4049\/jimmunol.166.12.7072","article-title":"IFN-gamma alters the pathology of graft rejection: protection from early necrosis","volume":"166","author":"Halloran","year":"2001","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib5","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.4049\/jimmunol.160.5.2059","article-title":"IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways","volume":"160","author":"Konieczny","year":"1998","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0002-9440(10)63845-X","article-title":"Neutrophils mediate parenchymal tissue necrosis and accelerate the rejection of complete major histocompatibility complex-disparate cardiac allografts in the absence of interferon-gamma","volume":"162","author":"Miura","year":"2003","journal-title":"Am J Pathol"},{"key":"10.2353\/ajpath.2010.091106_bib7","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.2353\/ajpath.2010.091106_bib8","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 family cytokines and the expanding diversity of effector T cell lineages","volume":"25","author":"Weaver","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib9","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.4049\/jimmunol.181.5.3456","article-title":"IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver","volume":"181","author":"Hamada","year":"2008","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib10","first-page":"829","article-title":"Cytokine-mediated regulation of antimicrobial proteins","volume":"8","author":"Kolls","year":"2008","journal-title":"Nat Rev Neurosci"},{"key":"10.2353\/ajpath.2010.091106_bib11","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1111\/j.1348-0421.2007.tb04008.x","article-title":"Interleukin-17 as an effector molecule of innate and acquired immunity against infections","volume":"51","author":"Matsuzaki","year":"2007","journal-title":"Microbiol Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib12","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.smim.2007.10.007","article-title":"Th17 cells: effector T cells with inflammatory properties","volume":"19","author":"Korn","year":"2007","journal-title":"Semin Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib13","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-065X.2008.00628.x","article-title":"Th17 cells in human disease","volume":"223","author":"Tesmer","year":"2008","journal-title":"Immunol Rev"},{"key":"10.2353\/ajpath.2010.091106_bib14","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jaut.2008.04.017","article-title":"Role of Th1 and Th17 cells in organ-specific autoimmunity","volume":"31","author":"Dardalhon","year":"2008","journal-title":"J Autoimmun"},{"key":"10.2353\/ajpath.2010.091106_bib15","first-page":"393","article-title":"Autoimmune T cell responses in the central nervous system","volume":"9","author":"Goverman","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.2353\/ajpath.2010.091106_bib16","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/j.1365-2249.2009.03944.x","article-title":"Interleukin-17 and systemic lupus erythematosus: current concepts","volume":"157","author":"Nalbandian","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/j.1432-2277.2001.tb00062.x","article-title":"IL-17 expression as a possible predictive parameter for subclinical renal allograft rejection","volume":"14","author":"Hsieh","year":"2001","journal-title":"Transpl Int"},{"key":"10.2353\/ajpath.2010.091106_bib19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/path.1117","article-title":"Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection","volume":"197","author":"Loong","year":"2002","journal-title":"J Pathol"},{"key":"10.2353\/ajpath.2010.091106_bib20","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1183\/09031936.06.00019405","article-title":"The role of interleukin-17 during acute rejection after lung transplantation","volume":"27","author":"Vanaudenaerde","year":"2006","journal-title":"Eur Respir J"},{"key":"10.2353\/ajpath.2010.091106_bib21","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.4049\/jimmunol.181.6.3906","article-title":"CD8+ Th17 mediate costimulation blockade-resistant allograft rejection in T-bet-deficient mice","volume":"181","author":"Burrell","year":"2008","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib22","doi-asserted-by":"crossref","first-page":"10734","DOI":"10.1073\/pnas.0812538106","article-title":"Targeting Tim-1 to overcome resistance to transplantation tolerance mediated by CD8 T17 cells","volume":"106","author":"Yuan","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.2353\/ajpath.2010.091106_bib23","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1084\/jem.20081937","article-title":"A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy","volume":"205","author":"Yuan","year":"2008","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.091106_bib24","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.ejcts.2006.01.052","article-title":"Gene transfer of soluble interleukin-17 receptor prolongs cardiac allograft survival in a rat model","volume":"29","author":"Li","year":"2006","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.2353\/ajpath.2010.091106_bib25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1097\/00007890-200107270-00035","article-title":"Interleukin-17 antagonism inhibits acute but not chronic vascular rejection","volume":"72","author":"Tang","year":"2001","journal-title":"Transplantation"},{"key":"10.2353\/ajpath.2010.091106_bib26","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00007890-197310000-00010","article-title":"Primarily vascularized allografts of hearts in mice: the role of H-2D, H-2K, and non-H-2 antigens in rejection","volume":"16","author":"Corry","year":"1973","journal-title":"Transplantation"},{"key":"10.2353\/ajpath.2010.091106_bib27","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.4049\/jimmunol.172.9.5456","article-title":"In vivo helper functions of alloreactive memory CD4+ T cells remain intact despite donor-specific transfusion and anti-CD40 ligand therapy","volume":"172","author":"Chen","year":"2004","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1034\/j.1600-6143.2002.20603.x","article-title":"Primed allospecific T cells prevent the effects of costimulatory blockade on prolonged cardiac allograft survival in mice","volume":"2","author":"Valujskikh","year":"2002","journal-title":"Am J Transplant"},{"key":"10.2353\/ajpath.2010.091106_bib29","doi-asserted-by":"crossref","first-page":"770","DOI":"10.4049\/jimmunol.176.2.770","article-title":"Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival","volume":"176","author":"Zhang","year":"2006","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib30","first-page":"250","article-title":"Enzyme linked immunosorbent spot (ELISPOT) assay for detection of alloreactive cytokine-secreting cells: detailed methods","volume":"3","author":"Valujskikh","year":"2000","journal-title":"Graft"},{"key":"10.2353\/ajpath.2010.091106_bib31","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1161\/CIRCULATIONAHA.104.516708","article-title":"Inhibition of polymorphonuclear leukocyte-mediated graft damage synergizes with short-term costimulatory blockade to prevent cardiac allograft rejection","volume":"112","author":"El-Sawy","year":"2005","journal-title":"Circulation"},{"key":"10.2353\/ajpath.2010.091106_bib32","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1111\/j.1600-6143.2008.02302.x","article-title":"Donor-reactive CD8 memory T cells infiltrate cardiac allografts within 24-h posttransplant in naive recipients","volume":"8","author":"Schenk","year":"2008","journal-title":"Am J Transplant"},{"key":"10.2353\/ajpath.2010.091106_bib33","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1084\/jem.184.5.2013","article-title":"CD4+ but not CD8+ cells are essential for allorejection","volume":"184","author":"Krieger","year":"1996","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.091106_bib34","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.trim.2004.10.005","article-title":"Role of CD4+ and CD8+ T cells in murine skin and heart allograft rejection across different antigenic desparities","volume":"13","author":"Youssef","year":"2004","journal-title":"Transpl Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib35","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1600-6143.2006.01236.x","article-title":"Anti-type V collagen lymphocytes that express IL-17 and IL-23 induce rejection pathology in fresh and well-healed lung transplants","volume":"6","author":"Yoshida","year":"2006","journal-title":"Am J Transplant"},{"key":"10.2353\/ajpath.2010.091106_bib36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1084\/jem.20081829","article-title":"The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion","volume":"206","author":"Haluszczak","year":"2009","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.091106_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1074-7613(02)00508-3","article-title":"Neonates support lymphopenia-induced proliferation","volume":"18","author":"Min","year":"2003","journal-title":"Immunity"},{"key":"10.2353\/ajpath.2010.091106_bib38","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/eji.1830160616","article-title":"Autonomous activation of B and T cells in antigen-free mice","volume":"16","author":"Pereira","year":"1986","journal-title":"Eur J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4049\/jimmunol.172.1.15","article-title":"Cutting edge: IL-7-dependent homeostatic proliferation of CD8+ T cells in neonatal mice allows the generation of long-lived natural memory T cells","volume":"172","author":"Schuler","year":"2004","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0041-1345(98)01453-5","article-title":"Evidence for a role of IL-17 in alloimmunity: a novel IL-17 antagonist promotes heart graft survival","volume":"31","author":"Antonysamy","year":"1999","journal-title":"Transplant Proc"},{"key":"10.2353\/ajpath.2010.091106_bib41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.4049\/jimmunol.162.1.577","article-title":"Evidence for a role of IL-17 in organ allograft rejection: IL-17 promotes the functional differentiation of dendritic cell progenitors","volume":"162","author":"Antonysamy","year":"1999","journal-title":"J Immunol"},{"key":"10.2353\/ajpath.2010.091106_bib42","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1359-6101(03)00002-9","article-title":"Interleukin-17 family and IL-17 receptors","volume":"14","author":"Moseley","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.2353\/ajpath.2010.091106_bib43","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.194.4.519","article-title":"Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense","volume":"194","author":"Ye","year":"2001","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.091106_bib44","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.20071978","article-title":"Regulation of inflammatory responses by IL-17F","volume":"205","author":"Yang","year":"2008","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.091106_bib45","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1002\/art.21342","article-title":"Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis","volume":"52","author":"Koenders","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.2353\/ajpath.2010.091106_bib46","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1165\/rcmb.2004-0213OC","article-title":"Interleukin-17 as a recruitment and survival factor for airway macrophages in allergic airway inflammation","volume":"33","author":"Sergejeva","year":"2005","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.2353\/ajpath.2010.091106_bib47","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/art.1780400609","article-title":"Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage","volume":"40","author":"Attur","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.2353\/ajpath.2010.091106_bib48","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1084\/jem.183.6.2593","article-title":"T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines","volume":"183","author":"Fossiez","year":"1996","journal-title":"J Exp Med"},{"key":"10.2353\/ajpath.2010.091106_bib49","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1681\/ASN.V11112044","article-title":"Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells","volume":"11","author":"Woltman","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.2353\/ajpath.2010.091106_bib50","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/1074-7613(95)90070-5","article-title":"Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor","volume":"3","author":"Yao","year":"1995","journal-title":"Immunity"},{"key":"10.2353\/ajpath.2010.091106_bib51","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.4049\/jimmunol.155.12.5483","article-title":"Human IL-17: a novel cytokine derived from T cells","volume":"155","author":"Yao","year":"1995","journal-title":"J Immunol"}],"container-title":["The American Journal of Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010601812?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0002944010601812?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T13:57:16Z","timestamp":1757599036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0002944010601812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["S0002944010601812"],"URL":"https:\/\/doi.org\/10.2353\/ajpath.2010.091106","relation":{},"ISSN":["0002-9440"],"issn-type":[{"value":"0002-9440","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interleukin-17 Promotes Early Allograft Inflammation","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/ajpath.2010.091106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}