{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:34:12Z","timestamp":1770824052100,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.2353\/jmoldx.2008.080054","type":"journal-article","created":{"date-parts":[[2008,10,3]],"date-time":"2008-10-03T00:25:31Z","timestamp":1222993531000},"page":"502-512","source":"Crossref","is-referenced-by-count":33,"title":["The Frequency of Immunoglobulin Heavy Chain Gene and T-Cell Receptor \u03b3-Chain Gene Rearrangements and Epstein-Barr Virus in ALK+ and ALK\u2212 Anaplastic Large Cell Lymphoma and Other Peripheral T-Cell Lymphomas"],"prefix":"10.1016","volume":"10","author":[{"given":"Brent T.","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Warnke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Arber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.2353\/jmoldx.2008.080054_bib1","series-title":"Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","first-page":"111","author":"Jaffe","year":"2001"},{"key":"10.2353\/jmoldx.2008.080054_bib2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/jcp.48.11.1045","article-title":"The polymerase chain reaction in the demonstration of monoclonality in T cell lymphomas","volume":"48","author":"Diss","year":"1995","journal-title":"J Clin Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00019606-200106000-00001","article-title":"IgH. TCR-gamma, and TCR-beta gene rearrangement in 80 B- and T-cell non-Hodgkin's lymphomas: study of the association between proliferation and the so-called \u201caberrant\u201d patterns","volume":"10","author":"Garcia","year":"2001","journal-title":"Diagn Mol Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1080\/1042819031000067747","article-title":"Characterization of T-cell non-Hodgkin's lymphoma and its association with Epstein-Barr virus in Pakistani patients","volume":"44","author":"Noorali","year":"2003","journal-title":"Leuk Lymphoma"},{"key":"10.2353\/jmoldx.2008.080054_bib5","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/modpathol.3880232","article-title":"PCR analysis of immunoglobulin heavy chain (IgH) and TcR-gamma chain gene rearrangements in the diagnosis of lymphoproliferative disorders: results of a study of 525 cases","volume":"13","author":"Th\u00e9riault","year":"2000","journal-title":"Mod Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/path.1192","article-title":"Combined analysis of T cell receptor gamma and immunoglobulin heavy chain gene rearrangements at the single-cell level in lymphomas with dual genotype","volume":"198","author":"Vergier","year":"2002","journal-title":"J Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib7","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2353\/jmoldx.2006.060016","article-title":"The frequency of B- and T-cell gene rearrangements and Epstein-Barr virus in T-cell lymphomas: a comparison between angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified with and without associated B-cell proliferations","volume":"8","author":"Tan","year":"2006","journal-title":"J Mol Diagn"},{"key":"10.2353\/jmoldx.2008.080054_bib8","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1309\/72CM-KAXF-66DE-4XVA","article-title":"Peripheral T-cell lymphoma complicated by a proliferation of large B cells","volume":"114","author":"Higgins","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib9","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1038\/sj.leu.2402642","article-title":"Angio-immunoblastic T cell lymphoma (AILD-TL) rich in large B cells and associated with Epstein-Barr virus infection: a different subtype of AILD-TL?","volume":"16","author":"Lome-Maldonado","year":"2002","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib10","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1309\/VD2D-98ME-MB3F-WH34","article-title":"Composite angioimmunoblastic T-cell lymphoma and diffuse large B-cell lymphoma: a case report and review of the literature","volume":"118","author":"Xu","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib11","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1309\/6UTX-GVC0-12ND-JJEU","article-title":"Epstein-Barr virus-associated B-cell lymphoproliferative disorders in angloimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified","volume":"117","author":"Zettl","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0009-8981(91)90247-A","article-title":"Analysis of immunoglobulin and T cell receptor genes. Part II: possibilities and limitations in the diagnosis and management of lymphoproliferative diseases and related disorders","volume":"198","author":"van Dongen","year":"1991","journal-title":"Clin Chim Acta"},{"key":"10.2353\/jmoldx.2008.080054_bib13","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1182\/blood.V61.6.1138.1138","article-title":"Lineage infidelity in acute leukemia","volume":"61","author":"Smith","year":"1983","journal-title":"Blood"},{"key":"10.2353\/jmoldx.2008.080054_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V67.1.1.1","article-title":"Lineage promiscuity in hemopoietic differentiation and leukemia","volume":"67","author":"Greaves","year":"1986","journal-title":"Blood"},{"key":"10.2353\/jmoldx.2008.080054_bib15","first-page":"235","article-title":"Lineage infidelity or lineage promiscuity?","volume":"1","author":"McCulloch","year":"1987","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1093\/ajcp\/85.4.490","article-title":"Advantages of detecting monoclonal antibody binding to tissue sections with biotin and avidin reagents in Coplin jars","volume":"85","author":"Bindl","year":"1986","journal-title":"Am J Clin Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib17","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98\u20133936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib18","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1182\/blood.V96.6.2254","article-title":"The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype","volume":"96","author":"Brumpt","year":"2000","journal-title":"Blood"},{"key":"10.2353\/jmoldx.2008.080054_bib19","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/sj.leu.2401071","article-title":"Immunoglobulin and T cell receptor gene rearrangement patterns in acute lymphoblastic leukemia are less mature in adults than in children: implications for selection of PCR targets for detection of minimal residual disease","volume":"12","author":"Szczepa\u0144ski","year":"1998","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib20","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1038\/sj.leu.2403038","article-title":"Age-related patterns of immunoglobulin and T-cell receptor gene rearrangements in precursor-B-ALL: implications for detection of minimal residual disease","volume":"17","author":"van der Velden","year":"2003","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.leu.2404481","article-title":"Powerful strategy for polymerase chain reaction-based clonality assessment in T-cell malignancies: Report of the BIOMED-2 Concerted Action BHM4 CT98-3936","volume":"21","author":"Br\u00fcggemann","year":"2007","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1525-1578(10)60622-8","article-title":"PCR analysis of the immunoglobulin heavy chain gene in polyclonal processes can yield pseudoclonal bands as an artifact of low B cell number","volume":"2","author":"Elenitoba-Johnson","year":"2000","journal-title":"J Mol Diagn"},{"key":"10.2353\/jmoldx.2008.080054_bib23","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1136\/mp.53.4.194","article-title":"Limitations of clonality analysis of B cell proliferations using CDR3 polymerase chain reaction","volume":"53","author":"Hoeve","year":"2000","journal-title":"Mol Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2133.2005.06947.x","article-title":"Primary cutaneous B-cell lymphoma (marginal zone) with prominent T-cell component and aberrant dual (T and B) genotype: diagnostic usefulness of laser-capture microdissection","volume":"154","author":"Gallardo","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.2353\/jmoldx.2008.080054_bib25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00019606-200009000-00002","article-title":"Clonal proliferation of B lymphocytes in the germinal centers of human reactive lymph nodes: possibility of overdiagnosis of B cell clonal proliferation","volume":"9","author":"Iijima","year":"2000","journal-title":"Diagn Mol Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1136\/mp.52.2.104","article-title":"Detection of clonal B cells in microdissected reactive lymphoproliferations: possible diagnostic pitfalls in PCR analysis of immunoglobulin heavy chain gene rearrangement","volume":"52","author":"Zhou","year":"1999","journal-title":"Mol Pathol"},{"key":"10.2353\/jmoldx.2008.080054_bib27","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/j.1460-2075.1984.tb01955.x","article-title":"Ordered rearrangement of immunoglobulin heavy chain variable region segments","volume":"3","author":"Alt","year":"1984","journal-title":"EMBO J"},{"key":"10.2353\/jmoldx.2008.080054_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.leu.2404479","article-title":"Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets: Report of the BIOMED-2 Concerted Action BHM4-CT98-3936","volume":"21","author":"Evans","year":"2007","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib29","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1084\/jem.184.4.1495","article-title":"Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells","volume":"184","author":"Kanzler","year":"1996","journal-title":"J Exp Med"},{"key":"10.2353\/jmoldx.2008.080054_bib30","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/eji.200323765","article-title":"Epstein-Barr virus (EBV)-positive lymphoproliferations in post-transplant patients show immunoglobulin V gene mutation patterns suggesting interference of EBV with normal B cell differentiation processes","volume":"33","author":"Br\u00e4uninger","year":"2003","journal-title":"Eur J Immunol"},{"key":"10.2353\/jmoldx.2008.080054_bib31","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0140-6736(03)12271-4","article-title":"Target cells of Epstein-Barr-virus (EBV)-positive post-transplant lymphoproliferative disease: similarities to EBV-positive Hodgkin's lymphoma","volume":"361","author":"Timms","year":"2003","journal-title":"Lancet"},{"key":"10.2353\/jmoldx.2008.080054_bib32","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1182\/blood-2003-05-1683","article-title":"Molecular histogenesis of posttransplantation lymphoproliferative disorders","volume":"102","author":"Capello","year":"2003","journal-title":"Blood"},{"key":"10.2353\/jmoldx.2008.080054_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1525-1578(10)60664-2","article-title":"Evaluation of T cell receptor testing in lymphoid neoplasms: results of a multicenter study of 29 extracted DNA and paraffin-embedded samples","volume":"3","author":"Arber","year":"2001","journal-title":"J Mol Diagn"},{"key":"10.2353\/jmoldx.2008.080054_bib34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1084-8592(99)80036-8","article-title":"Enhanced sensitivity with a novel TCRgamma PCR assay for clonality studies in 569 formalin-fixed, paraffin-embedded (FFPE) cases","volume":"4","author":"Krafft","year":"1999","journal-title":"Mol Diagn"},{"key":"10.2353\/jmoldx.2008.080054_bib35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2141.2007.06618.x","article-title":"A practical strategy for the routine use of BIOMED-2 PCR assays for detection of B- and T-cell clonality in diagnostic haematopathology","volume":"138","author":"Liu","year":"2007","journal-title":"Br J Haematol"},{"key":"10.2353\/jmoldx.2008.080054_bib36","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1525-1578(10)60580-6","article-title":"BIOMED-2 multiplex immunoglobulin\/T-cell receptor polymerase chain reaction protocols can reliably replace southern blot analysis in routine clonality diagnostics","volume":"7","author":"Sandberg","year":"2005","journal-title":"J Mol Diagn"},{"key":"10.2353\/jmoldx.2008.080054_bib37","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1182\/blood.V99.7.2315","article-title":"Comparative analysis of Ig and TCR gene rearrangements at diagnosis and at relapse of childhood precursor-B-ALL provides improved strategies for selection of stable PCR targets for monitoring of minimal residual disease","volume":"99","author":"Szczepa\u0144ski","year":"2002","journal-title":"Blood"},{"key":"10.2353\/jmoldx.2008.080054_bib38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1038\/sj.leu.2401277","article-title":"Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease","volume":"13","author":"Szczepa\u0144ski","year":"1999","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2008.080054_bib39","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S1525-1578(10)60456-4","article-title":"The distribution of gene segments in T-cell receptor gamma gene rearrangements demonstrates the need for multiple primer sets","volume":"5","author":"Lawnicki","year":"2003","journal-title":"J Mol Diagn"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157810601936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157810601936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:11:13Z","timestamp":1588968673000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157810601936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S1525157810601936"],"URL":"https:\/\/doi.org\/10.2353\/jmoldx.2008.080054","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}