{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:17:37Z","timestamp":1791231457711,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":3486,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jmdjournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Molecular Diagnostics"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.2353\/jmoldx.2010.090218","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T21:41:06Z","timestamp":1274996466000},"page":"520-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comprehensive Characterization of a Novel Intronic Pseudo-Exon Inserted within an e14\/a2 BCR-ABL Rearrangement in a Patient with Chronic Myeloid Leukemia"],"prefix":"10.1016","volume":"12","author":[{"given":"Nathalie","family":"Sorel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Mayeur-Rousse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Deverri\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Brottier-Mancini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guilhot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G.","family":"Turhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Claude","family":"Chomel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.2353\/jmoldx.2010.090218_bib1","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","article-title":"The molecular biology of chronic myeloid leukemia","volume":"96","author":"Deininger","year":"2000","journal-title":"Blood"},{"key":"10.2353\/jmoldx.2010.090218_bib2","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1182\/blood.V88.7.2375.bloodjournal8872375","article-title":"The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype","volume":"88","author":"Melo","year":"1996","journal-title":"Blood"},{"key":"10.2353\/jmoldx.2010.090218_bib3","first-page":"186","article-title":"An optimized multiplex polymerase chain reaction (PCR) for detection of BCR-ABL fusion mRNAs in haematological disorders","volume":"8","author":"Cross","year":"1994","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2010.090218_bib4","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/nar\/gkp215","article-title":"Human Splicing Finder: an online bioinformatics tool to predict splicing signals","volume":"37","author":"Desmet","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/jmoldx.2010.090218_bib5","doi-asserted-by":"crossref","first-page":"W189","DOI":"10.1093\/nar\/gkp320","article-title":"SROOGLE: webserver for integrative, user-friendly visualization of splicing signals","volume":"37","author":"Schwartz","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/jmoldx.2010.090218_bib6","doi-asserted-by":"crossref","first-page":"W451","DOI":"10.1093\/nar\/gki487","article-title":"GeneMark: web software for gene finding in prokaryotes, eukaryotes and viruses","volume":"33","author":"Besemer","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"10.2353\/jmoldx.2010.090218_bib7","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1046\/j.1365-2141.2000.02205.x","article-title":"Novel BCR-ABL transcript containing an intronic sequence insert in a patient with Philadelphia-positive acute lymphoblastic leukaemia","volume":"110","author":"Hirota","year":"2000","journal-title":"Br J Haematol"},{"key":"10.2353\/jmoldx.2010.090218_bib8","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1046\/j.1365-2141.1997.d01-2066.x","article-title":"A novel acute lymphoid leukaemia type BCR\/ABL transcript in chronic myelogenous leukaemia","volume":"96","author":"Okamoto","year":"1997","journal-title":"Br J Haematol"},{"key":"10.2353\/jmoldx.2010.090218_bib9","first-page":"644","article-title":"Novel type of BCR-ABL transcript in a chronic myelogenous leukaemia patient relapsed after bone marrow transplantation","volume":"111","author":"Roman","year":"2000","journal-title":"Br J Haematol"},{"key":"10.2353\/jmoldx.2010.090218_bib10","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1046\/j.1365-2141.2000.02042.x","article-title":"A novel BCR-ABL transcript (e8a2) with the insertion of an inverted sequence of ABL intron 1b in a patient with Philadelphia-positive chronic myeloid leukaemia","volume":"109","author":"Branford","year":"2000","journal-title":"Br J Haematol"},{"key":"10.2353\/jmoldx.2010.090218_bib11","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/sj.leu.2401547","article-title":"Translisin recognition site sequences flank translocation breakpoints in a Philadelphia chromosome positive chronic myeloid leukemia patient expressing a novel type of chimeric BCR-ABL transcript (E8-INT-A2)","volume":"13","author":"Martinelli","year":"1999","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2010.090218_bib12","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1159\/000178145","article-title":"Imatinib mesylate resistance in a chronic myeloid leukemia patient with a novel e8a2 BCR-ABL transcript variant","volume":"120","author":"Qin","year":"2008","journal-title":"Acta Haematol"},{"key":"10.2353\/jmoldx.2010.090218_bib13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cancergencyto.2008.06.001","article-title":"A case of chronic myelogenous leukemia with e8a2 fusion transcript","volume":"185","author":"Park","year":"2008","journal-title":"Cancer Genet Cytogenet"},{"key":"10.2353\/jmoldx.2010.090218_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/sj.leu.2404012","article-title":"Major molecular response to imatinib in a patient with chronic myeloid leukemia expressing a novel form of e8a2 BCR-ABL transcript","volume":"20","author":"Tchirkov","year":"2006","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2010.090218_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/sj.leu.2400917","article-title":"A novel BCR-ABL rearrangement in a Philadelphia chromosome-positive chronic myelogenous leukaemia variant with thrombocythaemia","volume":"12","author":"Rubinstein","year":"1998","journal-title":"Leukemia"},{"key":"10.2353\/jmoldx.2010.090218_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3109\/10428190109057996","article-title":"Aberrant BCR-ABL transcript with intronic insertion in a patient with Philadelphia chromosome-positive chronic myeloid leukemia: implications for disease progression","volume":"41","author":"Shiratsuchi","year":"2001","journal-title":"Leuk Lymphoma"},{"key":"10.2353\/jmoldx.2010.090218_bib17","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1365-2141.2004.05119.x","article-title":"Insertion of a genomic fragment of chromosome 19 between BCR intron 19 and ABL intron 1a in a chronic myeloid leukaemia patient with micro-BCR-ABL (e19a2) transcript","volume":"126","author":"Ito","year":"2004","journal-title":"Br J Haematol"},{"key":"10.2353\/jmoldx.2010.090218_bib18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ajh.20138","article-title":"Second case of CML with aberrant BCR-ABL fusion transcript (e8\/a2) with insertion of an inverted ABL intron 1b sequence","volume":"77","author":"Sugimoto","year":"2004","journal-title":"Am J Hematol"},{"key":"10.2353\/jmoldx.2010.090218_bib19","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1038\/sj.leu.2403135","article-title":"Standardization and quality control studies of \u201creal-time\u201d quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia\u2014a Europe Against Cancer program","volume":"17","author":"Gabert","year":"2003","journal-title":"Leukemia"}],"container-title":["The Journal of Molecular Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157810600943?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1525157810600943?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T18:11:54Z","timestamp":1761502314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1525157810600943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S1525157810600943"],"URL":"https:\/\/doi.org\/10.2353\/jmoldx.2010.090218","relation":{},"ISSN":["1525-1578"],"issn-type":[{"value":"1525-1578","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive Characterization of a Novel Intronic Pseudo-Exon Inserted within an e14\/a2 BCR-ABL Rearrangement in a Patient with Chronic Myeloid Leukemia","name":"articletitle","label":"Article Title"},{"value":"The Journal of Molecular Diagnostics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.2353\/jmoldx.2010.090218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 American Society for Investigative Pathology and Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}