{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T14:44:11Z","timestamp":1648997051173},"reference-count":99,"publisher":"Edizioni Minerva Medica","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Minerva Anestesiol"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.23736\/s0375-9393.20.14663-7","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T16:42:34Z","timestamp":1606149754000},"source":"Crossref","is-referenced-by-count":1,"title":["Coronavirus disease 2019 in critically ill patients: can we re-program the immune system? A primer for Intensivists"],"prefix":"10.23736","volume":"86","author":[{"given":"Fiorenza","family":"Ferrari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"Visconti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara","family":"De Amici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Guglielmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costanza N.","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirko","family":"Belliato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Ronco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"17149","reference":[{"key":"10.23736\/S0375-9393.20.14663-7_ref001","first-page":"ahead of print","article-title":"The definition and risks of Cytokine Release Syndrome-Like in 11 COVID-19-Infected Pneumonia critically ill patients: Disease Characteristics and Retrospective Analysis","author":"Wang W","year":"2020","journal-title":"MedRxiv and BioRxiv"},{"key":"10.23736\/S0375-9393.20.14663-7_ref002","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa248"},{"key":"10.23736\/S0375-9393.20.14663-7_ref003","unstructured":"Expert Consensus on Comprehensive Treatment of Coronavirus in Shanghai 2019; 2020 [Internet]. Available from: https:\/\/medicina.furg.br\/images\/7_Expert_consensus_on_comprehensive_treatment_of_COVID-19_in_Shanghai.pdf [cited 2020, Sep 23]."},{"key":"10.23736\/S0375-9393.20.14663-7_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"10.23736\/S0375-9393.20.14663-7_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102567"},{"key":"10.23736\/S0375-9393.20.14663-7_ref006","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa363"},{"key":"10.23736\/S0375-9393.20.14663-7_ref007","first-page":"ahead of print","article-title":"Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia","author":"Chen L","year":"2020","journal-title":"Zhonghua Jie He He Hu Xi Za Zhi"},{"key":"10.23736\/S0375-9393.20.14663-7_ref008","first-page":"ahead of print","article-title":"Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome","author":"Yang Y","year":"2020","journal-title":"MedRxiv"},{"key":"10.23736\/S0375-9393.20.14663-7_ref009","unstructured":"Liu Y, Zhang C, Huang F, Yang Y, Wang F, Yuan J, et al. 2019-novel Coronavirus (2019-nCoV) Infections Trigger an Exaggerated Cytokine Response Aggravating Lung Injury; 2020 [Internet]. Available from: http:\/\/www.chinaxiv.org\/abs\/ [cited 2020, April 30]."},{"key":"10.23736\/S0375-9393.20.14663-7_ref010","first-page":"1","article-title":"Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic","volume":"38","author":"Prompetchara E","year":"2020","journal-title":"Asian Pac J Allergy Immunol"},{"key":"10.23736\/S0375-9393.20.14663-7_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"10.23736\/S0375-9393.20.14663-7_ref012","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25685"},{"key":"10.23736\/S0375-9393.20.14663-7_ref013","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2762"},{"key":"10.23736\/S0375-9393.20.14663-7_ref014","doi-asserted-by":"publisher","DOI":"10.1038\/nri1732"},{"key":"10.23736\/S0375-9393.20.14663-7_ref015","doi-asserted-by":"publisher","DOI":"10.1159\/000507039"},{"key":"10.23736\/S0375-9393.20.14663-7_ref016","unstructured":"Ugazio AG, Marseglia GL. Immunologia e Allergologia Pediatrica. Pisa: Pacini Editore; 2017."},{"key":"10.23736\/S0375-9393.20.14663-7_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.016"},{"key":"10.23736\/S0375-9393.20.14663-7_ref018","unstructured":"Filice G. Infezioni, malattie da virus. Second edition. Pavia, Italy: Edimes; 2006."},{"key":"10.23736\/S0375-9393.20.14663-7_ref019","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00167"},{"key":"10.23736\/S0375-9393.20.14663-7_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.09.017"},{"key":"10.23736\/S0375-9393.20.14663-7_ref021","unstructured":"Murphy KM, Travers P, Walport M. Janeway's immunobiology. Seventh edition. New York: Garland Science; 2007."},{"key":"10.23736\/S0375-9393.20.14663-7_ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2015.06.019"},{"key":"10.23736\/S0375-9393.20.14663-7_ref023","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.101"},{"key":"10.23736\/S0375-9393.20.14663-7_ref024","doi-asserted-by":"publisher","DOI":"10.1038\/nri1027"},{"key":"10.23736\/S0375-9393.20.14663-7_ref025","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00427.x"},{"key":"10.23736\/S0375-9393.20.14663-7_ref026","doi-asserted-by":"publisher","DOI":"10.1038\/nri2785"},{"key":"10.23736\/S0375-9393.20.14663-7_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108408"},{"key":"10.23736\/S0375-9393.20.14663-7_ref028","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2020.04.008"},{"key":"10.23736\/S0375-9393.20.14663-7_ref029","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.04.024"},{"key":"10.23736\/S0375-9393.20.14663-7_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.065"},{"key":"10.23736\/S0375-9393.20.14663-7_ref031","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.026"},{"key":"10.23736\/S0375-9393.20.14663-7_ref032","first-page":"215","article-title":"Interleukin-1 receptor antagonist anakinra in association with remdesivir in severe Coronavirus disease 2019: A case report","volume":"97","author":"Franzetti M","year":"2020","journal-title":"Int J Infect Dis"},{"key":"10.23736\/S0375-9393.20.14663-7_ref033","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16873"},{"key":"10.23736\/S0375-9393.20.14663-7_ref034","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.05.002"},{"key":"10.23736\/S0375-9393.20.14663-7_ref035","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30127-2"},{"key":"10.23736\/S0375-9393.20.14663-7_ref036","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217706"},{"key":"10.23736\/S0375-9393.20.14663-7_ref037","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.05.007"},{"key":"10.23736\/S0375-9393.20.14663-7_ref038","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26062"},{"key":"10.23736\/S0375-9393.20.14663-7_ref039","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005615117"},{"key":"10.23736\/S0375-9393.20.14663-7_ref040","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.05.021"},{"key":"10.23736\/S0375-9393.20.14663-7_ref041","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102568"},{"key":"10.23736\/S0375-9393.20.14663-7_ref042","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25801"},{"key":"10.23736\/S0375-9393.20.14663-7_ref043","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001907"},{"key":"10.23736\/S0375-9393.20.14663-7_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.03.300"},{"key":"10.23736\/S0375-9393.20.14663-7_ref045","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.04.024"},{"key":"10.23736\/S0375-9393.20.14663-7_ref046","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.04.009"},{"key":"10.23736\/S0375-9393.20.14663-7_ref047","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2020.03.010"},{"key":"10.23736\/S0375-9393.20.14663-7_ref048","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8050695"},{"key":"10.23736\/S0375-9393.20.14663-7_ref049","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26016"},{"key":"10.23736\/S0375-9393.20.14663-7_ref050","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcaa153"},{"key":"10.23736\/S0375-9393.20.14663-7_ref051","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15935"},{"key":"10.23736\/S0375-9393.20.14663-7_ref052","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15985"},{"key":"10.23736\/S0375-9393.20.14663-7_ref053","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106043"},{"key":"10.23736\/S0375-9393.20.14663-7_ref054","first-page":"578","article-title":"Early tocilizumab treatment could improve survival among COVID-19 patients","volume":"38","author":"Campins L","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"10.23736\/S0375-9393.20.14663-7_ref055","first-page":"227","article-title":"[Clinical observation of 6 severe COVID-19 patients treated with plasma exchange or tocilizumab]","volume":"49","author":"Luo S","year":"2020","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"key":"10.23736\/S0375-9393.20.14663-7_ref056","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2020.04.025"},{"key":"10.23736\/S0375-9393.20.14663-7_ref057","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26149"},{"key":"10.23736\/S0375-9393.20.14663-7_ref058","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25907"},{"key":"10.23736\/S0375-9393.20.14663-7_ref059","doi-asserted-by":"publisher","DOI":"10.12890\/2020_001675"},{"key":"10.23736\/S0375-9393.20.14663-7_ref060","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25964"},{"key":"10.23736\/S0375-9393.20.14663-7_ref061","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.05.009"},{"key":"10.23736\/S0375-9393.20.14663-7_ref062","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25833"},{"key":"10.23736\/S0375-9393.20.14663-7_ref063","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2020.05.001"},{"key":"10.23736\/S0375-9393.20.14663-7_ref064","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25897"},{"key":"10.23736\/S0375-9393.20.14663-7_ref065","first-page":"529","article-title":"Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in patients with severe COVID-19","volume":"38","author":"Sciascia S","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"10.23736\/S0375-9393.20.14663-7_ref066","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2020.05.011"},{"key":"10.23736\/S0375-9393.20.14663-7_ref067","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2020.05.005"},{"key":"10.23736\/S0375-9393.20.14663-7_ref068","first-page":"5783","article-title":"Tocilizumab in the treatment of a critical COVID-19 patient: a case report","volume":"24","author":"Wang L","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.23736\/S0375-9393.20.14663-7_ref069","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25855"},{"key":"10.23736\/S0375-9393.20.14663-7_ref070","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104443"},{"key":"10.23736\/S0375-9393.20.14663-7_ref071","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26110"},{"key":"10.23736\/S0375-9393.20.14663-7_ref072","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-020-1901-z"},{"key":"10.23736\/S0375-9393.20.14663-7_ref073","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138554"},{"key":"10.23736\/S0375-9393.20.14663-7_ref074","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102575"},{"key":"10.23736\/S0375-9393.20.14663-7_ref075","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13334"},{"key":"10.23736\/S0375-9393.20.14663-7_ref076","doi-asserted-by":"publisher","DOI":"10.1159\/000507417"},{"key":"10.23736\/S0375-9393.20.14663-7_ref077","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/liv.14516","article-title":"First case of drug-induced liver injury associated with the use of tocilizumab in a patient with COVID-19","volume":"40","author":"Muhovi\u0107 D","year":"2020","journal-title":"Liver Int"},{"key":"10.23736\/S0375-9393.20.14663-7_ref078","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2020.104444"},{"key":"10.23736\/S0375-9393.20.14663-7_ref079","article-title":"Intestinal perforation in patient with COVID-19 infection treated with tocilizumab and corticosteroids. Report of a clinical case","author":"Gonz\u00e1lvez Guardiola P","year":"2020","journal-title":"Cir Esp"},{"key":"10.23736\/S0375-9393.20.14663-7_ref080","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15982"},{"key":"10.23736\/S0375-9393.20.14663-7_ref081","doi-asserted-by":"publisher","DOI":"10.7326\/L20-0419"},{"key":"10.23736\/S0375-9393.20.14663-7_ref082","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26111"},{"key":"10.23736\/S0375-9393.20.14663-7_ref083","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102182"},{"key":"10.23736\/S0375-9393.20.14663-7_ref084","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16080"},{"key":"10.23736\/S0375-9393.20.14663-7_ref085","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16787"},{"key":"10.23736\/S0375-9393.20.14663-7_ref086","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13348"},{"key":"10.23736\/S0375-9393.20.14663-7_ref087","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.05.022"},{"key":"10.23736\/S0375-9393.20.14663-7_ref088","doi-asserted-by":"publisher","DOI":"10.1111\/tid.13326"},{"key":"10.23736\/S0375-9393.20.14663-7_ref089","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1594.2003.07289.x"},{"key":"10.23736\/S0375-9393.20.14663-7_ref090","doi-asserted-by":"publisher","DOI":"10.1177\/039139880402701211"},{"key":"10.23736\/S0375-9393.20.14663-7_ref091","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000115262.31804.46"},{"key":"10.23736\/S0375-9393.20.14663-7_ref092","doi-asserted-by":"publisher","DOI":"10.1177\/039139880502800803"},{"key":"10.23736\/S0375-9393.20.14663-7_ref093","doi-asserted-by":"publisher","DOI":"10.1159\/000313773"},{"key":"10.23736\/S0375-9393.20.14663-7_ref094","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31829eb98f"},{"key":"10.23736\/S0375-9393.20.14663-7_ref095","doi-asserted-by":"publisher","DOI":"10.1042\/CS20120668"},{"key":"10.23736\/S0375-9393.20.14663-7_ref096","unstructured":"UpToDate Tocilizumab. Drug information UpToDate Inc. and\/or its affiliates; \u00a92020 [Internet]. Available from https:\/\/www.uptodate.com\/contents\/tocilizumab-drug-information#F9773765 [cited 2020, June 19]."},{"key":"10.23736\/S0375-9393.20.14663-7_ref097","unstructured":"UpToDate Sarilumab. Drug information. UpToDate Inc. and\/or its affiliates; \u00a92020 [Internet]. Available from https:\/\/www.uptodate.com\/contents\/sarilumab-drug-information?source=see_link#F50133614 [cited 2020, June 19]."},{"key":"10.23736\/S0375-9393.20.14663-7_ref098","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2018894618"},{"key":"10.23736\/S0375-9393.20.14663-7_ref099","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2015.00004"}],"container-title":["Minerva Anestesiologica"],"original-title":[],"link":[{"URL":"https:\/\/www.minervamedica.it\/pdf.php?cod=R02Y2020N11A1214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T16:46:48Z","timestamp":1606150008000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.minervamedica.it\/index2.php?show=R02Y2020N11A1214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":99,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.23736\/s0375-9393.20.14663-7","relation":{},"ISSN":["0375-9393","1827-1596"],"issn-type":[{"value":"0375-9393","type":"print"},{"value":"1827-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11]]}}}