{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:15:11Z","timestamp":1788401711438,"version":"build-2803163510"},"reference-count":81,"publisher":"Edizioni Minerva Medica","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Minerva Anestesiol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.23736\/s0375-9393.20.14822-3","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T08:49:21Z","timestamp":1613638161000},"source":"Crossref","is-referenced-by-count":29,"title":["Chronic cancer and non-cancer pain and opioid-induced hyperalgesia share common mechanisms: neuroinflammation and central sensitization"],"prefix":"10.23736","volume":"87","author":[{"given":"Angela","family":"SANTONI","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"MERCADANTE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"ARCURI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"17149","reference":[{"key":"10.23736\/S0375-9393.20.14822-3_ref001","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001390"},{"key":"10.23736\/S0375-9393.20.14822-3_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.09.004"},{"key":"10.23736\/S0375-9393.20.14822-3_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(97)00222-1"},{"key":"10.23736\/S0375-9393.20.14822-3_ref004","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-018-2579-4"},{"key":"10.23736\/S0375-9393.20.14822-3_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.10.001"},{"key":"10.23736\/S0375-9393.20.14822-3_ref006","doi-asserted-by":"publisher","DOI":"10.1038\/nm908"},{"key":"10.23736\/S0375-9393.20.14822-3_ref007","doi-asserted-by":"publisher","DOI":"10.1038\/3942"},{"key":"10.23736\/S0375-9393.20.14822-3_ref008","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4334"},{"key":"10.23736\/S0375-9393.20.14822-3_ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"10.23736\/S0375-9393.20.14822-3_ref010","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.162"},{"key":"10.23736\/S0375-9393.20.14822-3_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(90)90228-Z"},{"key":"10.23736\/S0375-9393.20.14822-3_ref012","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1852"},{"key":"10.23736\/S0375-9393.20.14822-3_ref013","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000389"},{"key":"10.23736\/S0375-9393.20.14822-3_ref014","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3859-11.2011"},{"key":"10.23736\/S0375-9393.20.14822-3_ref015","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3858"},{"key":"10.23736\/S0375-9393.20.14822-3_ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2004.06.006"},{"key":"10.23736\/S0375-9393.20.14822-3_ref017","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002130"},{"key":"10.23736\/S0375-9393.20.14822-3_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.04.025"},{"key":"10.23736\/S0375-9393.20.14822-3_ref019","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1140"},{"key":"10.23736\/S0375-9393.20.14822-3_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.022"},{"key":"10.23736\/S0375-9393.20.14822-3_ref021","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001384"},{"key":"10.23736\/S0375-9393.20.14822-3_ref022","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000507"},{"key":"10.23736\/S0375-9393.20.14822-3_ref023","first-page":"94","article-title":"Pain mechanisms in rheumatoid arthritis","volume":"35","author":"McWilliams DF","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"10.23736\/S0375-9393.20.14822-3_ref024","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001574"},{"key":"10.23736\/S0375-9393.20.14822-3_ref025","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2018.20"},{"key":"10.23736\/S0375-9393.20.14822-3_ref026","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000417"},{"key":"10.23736\/S0375-9393.20.14822-3_ref027","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460344.54470.20"},{"key":"10.23736\/S0375-9393.20.14822-3_ref028","doi-asserted-by":"publisher","DOI":"10.1126\/science.1171759"},{"key":"10.23736\/S0375-9393.20.14822-3_ref029","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000154RR"},{"key":"10.23736\/S0375-9393.20.14822-3_ref030","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.078162"},{"key":"10.23736\/S0375-9393.20.14822-3_ref031","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10146"},{"key":"10.23736\/S0375-9393.20.14822-3_ref032","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200002000-00029"},{"key":"10.23736\/S0375-9393.20.14822-3_ref033","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2006.12.004"},{"key":"10.23736\/S0375-9393.20.14822-3_ref034","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-062613-093100"},{"key":"10.23736\/S0375-9393.20.14822-3_ref035","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1200130109"},{"key":"10.23736\/S0375-9393.20.14822-3_ref036","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.08.002"},{"key":"10.23736\/S0375-9393.20.14822-3_ref037","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2012.08.003"},{"key":"10.23736\/S0375-9393.20.14822-3_ref038","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(02)00599-3"},{"key":"10.23736\/S0375-9393.20.14822-3_ref039","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1602070113"},{"key":"10.23736\/S0375-9393.20.14822-3_ref040","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134441"},{"key":"10.23736\/S0375-9393.20.14822-3_ref041","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.06.009"},{"key":"10.23736\/S0375-9393.20.14822-3_ref042","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000570"},{"key":"10.23736\/S0375-9393.20.14822-3_ref043","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00660-0"},{"key":"10.23736\/S0375-9393.20.14822-3_ref044","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04046-0"},{"key":"10.23736\/S0375-9393.20.14822-3_ref045","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198612253152606"},{"key":"10.23736\/S0375-9393.20.14822-3_ref046","unstructured":"Virchow R. Die cellular pathologie in ihrer begr\u00fcndung auf physiologische und pathologische gewebelehre. Berlin; Hirschwald; 1858."},{"key":"10.23736\/S0375-9393.20.14822-3_ref047","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0006-7"},{"key":"10.23736\/S0375-9393.20.14822-3_ref048","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.101"},{"key":"10.23736\/S0375-9393.20.14822-3_ref049","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.0000000000000010"},{"key":"10.23736\/S0375-9393.20.14822-3_ref050","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2009.11.001"},{"key":"10.23736\/S0375-9393.20.14822-3_ref051","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1219-y"},{"key":"10.23736\/S0375-9393.20.14822-3_ref052","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-24-10886.1999"},{"key":"10.23736\/S0375-9393.20.14822-3_ref053","doi-asserted-by":"publisher","DOI":"10.1038\/nrc747"},{"key":"10.23736\/S0375-9393.20.14822-3_ref054","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10999"},{"key":"10.23736\/S0375-9393.20.14822-3_ref055","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(02)00102-1"},{"key":"10.23736\/S0375-9393.20.14822-3_ref056","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.7219"},{"key":"10.23736\/S0375-9393.20.14822-3_ref057","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1914"},{"key":"10.23736\/S0375-9393.20.14822-3_ref058","first-page":"1059","article-title":"Opioid receptors and endogenous opioids in diverse human and animal cancers","volume":"79","author":"Zagon IS","year":"1987","journal-title":"J Natl Cancer Inst"},{"key":"10.23736\/S0375-9393.20.14822-3_ref059","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712033172304"},{"key":"10.23736\/S0375-9393.20.14822-3_ref060","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000306"},{"key":"10.23736\/S0375-9393.20.14822-3_ref061","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-0713-7"},{"key":"10.23736\/S0375-9393.20.14822-3_ref062","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2541"},{"key":"10.23736\/S0375-9393.20.14822-3_ref063","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.10.003"},{"key":"10.23736\/S0375-9393.20.14822-3_ref064","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(99)00227-X"},{"key":"10.23736\/S0375-9393.20.14822-3_ref065","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13750"},{"key":"10.23736\/S0375-9393.20.14822-3_ref066","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)90084-1"},{"key":"10.23736\/S0375-9393.20.14822-3_ref067","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(03)00258-6"},{"key":"10.23736\/S0375-9393.20.14822-3_ref068","first-page":"78","article-title":"Can tumors act as opioid traps, mimicking opioid tolerance?","volume":"16","author":"Arcuri E","year":"1998","journal-title":"J Pain Symptom Manage"},{"key":"10.23736\/S0375-9393.20.14822-3_ref069","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(02)00425-6"},{"key":"10.23736\/S0375-9393.20.14822-3_ref070","first-page":"40","article-title":"Breakthrough pain: a single mask for varying painful situations: Therapeutic reflexes in cancer pain","volume":"1","author":"Arcuri E","year":"2012","journal-title":"Transl Med (Sunnyvale)"},{"key":"10.23736\/S0375-9393.20.14822-3_ref071","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(98)90005-6"},{"key":"10.23736\/S0375-9393.20.14822-3_ref072","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4371-x"},{"key":"10.23736\/S0375-9393.20.14822-3_ref073","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02914"},{"key":"10.23736\/S0375-9393.20.14822-3_ref074","doi-asserted-by":"publisher","DOI":"10.23736\/S0375-9393.19.13321-4"},{"key":"10.23736\/S0375-9393.20.14822-3_ref075","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.06.011"},{"key":"10.23736\/S0375-9393.20.14822-3_ref076","doi-asserted-by":"publisher","DOI":"10.1038\/nri3621"},{"key":"10.23736\/S0375-9393.20.14822-3_ref077","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.12.016"},{"key":"10.23736\/S0375-9393.20.14822-3_ref078","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2020.07.010"},{"key":"10.23736\/S0375-9393.20.14822-3_ref079","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2004.05.012"},{"key":"10.23736\/S0375-9393.20.14822-3_ref080","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2004.05.011"},{"key":"10.23736\/S0375-9393.20.14822-3_ref081","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.029"}],"container-title":["Minerva Anestesiologica"],"original-title":[],"link":[{"URL":"https:\/\/www.minervamedica.it\/pdf.php?cod=R02Y2021N02A0210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T08:51:48Z","timestamp":1613638308000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.minervamedica.it\/index2.php?show=R02Y2021N02A0210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":81,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.23736\/s0375-9393.20.14822-3","relation":{"is-cited-by":[{"id-type":"doi","id":"10.23736\/S0375-9393.20.15384-7","asserted-by":"object"}]},"ISSN":["0375-9393","1827-1596"],"issn-type":[{"value":"0375-9393","type":"print"},{"value":"1827-1596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]}}}