{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:20:49Z","timestamp":1790662849369,"version":"4.1.0"},"reference-count":0,"publisher":"Mattioli1885","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,29]]},"abstract":"<jats:p>Background: The relationship between pleural plaques and cumulative asbestos exposure is controversial. Objectives: To evaluate the relationship between lung asbestos bodies (AB) and fibres (AF) and plaques presence and extension. Methods: In a necropsy series of shipyard workers with asbestos-related diseases, we measured counts (per g of dry lung tissue) of AB (thousands) and AF&gt;1 \u00b5m (millions). Pleural plaques were classified into three extension grades. We fitted univariate and multivariable linear (dependent variables: AB and AF, log10 transformed) and multinomial (dependent variable: plaques grade) regression models. Results: We analysed 124 subjects, 13 without plaques 20 with grade 1, 69 with grade 2, and 22 with grade 3 plaques. Geometric means (GM) of AB were 10.6, 23.3, 126, and 140 in the four groups respectively (P=0.0001). GMs for AF (mostly amphiboles) were 1.2, 1.4, 7.3, and 12.9 (P=0.0001). AB and AF were strongly correlated (r=0.81). The likelihood of no plaques and grade 1 plaques decreased with increasing AB and AF doses, with a corresponding increase of grade 2 and 3 plaques. Plaque presence and extension was also associated with histologically verified asbestosis (P&lt;0.001). Conclusions: Our study showed a strong positive relationship between pleural plaque presence and extension and both lung asbestos burden and asbestosis.<\/jats:p>","DOI":"10.23749\/mdl.v110i5.8471","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:58:01Z","timestamp":1741179481000},"page":"353-362","source":"Crossref","is-referenced-by-count":1,"title":["Relationship between pleural plaques and biomarkers of cumulative asbestos dose. A necropsy study","Correlazione tra presenza ed estensione delle placche pleuriche e indicatori biologici di esposizione ad asbesto. Uno studio autoptico"],"prefix":"10.23749","volume":"110","author":[{"given":"Pietro Gino","family":"Barbieri","sequence":"additional","affiliation":[{"name":"nessuna"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Consonni","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Somigliana","sequence":"additional","affiliation":[{"name":"Lombardy Regional Protection Agency (ARPA), Air Unit, Electron Microscopy Centre, Milan Department, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","container-title":["La Medicina del Lavoro","La Medicina del Lavoro | Work, Environment and Health"],"original-title":[],"link":[{"URL":"https:\/\/www.mattioli1885journals.com\/index.php\/lamedicinadellavoro\/article\/download\/8471\/8322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.mattioli1885journals.com\/index.php\/lamedicinadellavoro\/article\/download\/8471\/8322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T15:14:02Z","timestamp":1741792442000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mattioli1885journals.com\/index.php\/lamedicinadellavoro\/article\/view\/8471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,29]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.23749\/mdl.v110i5.8471","relation":{"has-manifestation":[{"id-type":"other","id":"4-718-8471-g8322","asserted-by":"subject"}],"is-part-of":[{"id-type":"other","id":"4-718","asserted-by":"subject"}]},"ISSN":["2532-1080","0025-7818"],"issn-type":[{"value":"2532-1080","type":"electronic"},{"value":"0025-7818","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,29]]},"article-number":"2"}}