{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:37:43Z","timestamp":1753889863240,"version":"3.41.2"},"reference-count":40,"publisher":"Mattioli1885","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,7]]},"abstract":"<jats:p>Background: Tobacco use and alcohol consumption are the primary risk factors for laryngeal cancer (LC). In most populations, occupational exposures are likely to play a minor role in laryngeal carcinogenesis. We aimed to investigate the association between occupational exposure and laryngeal cancer. Methods: It is a case-control study that included 140 cases diagnosed between January 2013 and December 2016 and 140 controls matched by sex, age, alcohol consumption, and tobacco consumption. Results: Significantly increased risks were found amongst workers of the building sector (OR=4.621; 95% CI [1.826-11.693]) and the mechanical industry sector (OR=5.074; 95% CI [1.425-18.072]). Significant association of laryngeal cancer with various carcinogens was observed such as asbestos (p=0.009; OR=3.68; 95% CI [1.29-10.46]), paint vapors (p=0.005; OR=3.35; 95% CI [1.37-8.16]), solvents (p=0.001; OR=3.29: 95% CI [1.61-6.68]) and cement dust (p=0.003; OR=3.19: 95% CI [1.43-7.12]). After binary logistic regression, cement dust was independently correlated with LC (p=0.042; OR=3.93; 95% CI [1.04-14.78]. The administration sector was associated with decreased risk (p=0.001; OR=0.07; 95% CI [0.03-0.15]) as well as the health sector (p=0.001; OR=0.098; 95% CI [0.02-0.43]). Conclusions: Our results supported the role of occupational factors in developing LC. Further studies enabling an in-depth analysis of occupational exposures are necessary to provide a clearer definition of the etiological associations between single agents and circumstances of exposure and the genesis of LC.<\/jats:p>","DOI":"10.23749\/mdl.v114i6.14588","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:58:01Z","timestamp":1741179481000},"page":"e2023047","source":"Crossref","is-referenced-by-count":0,"title":["Occupational Risk Factors for Laryngeal Cancer in Tunisia: A Case Control Study"],"prefix":"10.23749","volume":"114","author":[{"given":"Asma","family":"Gaddour","sequence":"first","affiliation":[{"name":"Department of Occupational Medicine, Faculty of Medicine of Sousse, University of Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aicha","family":"Brahem","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiba","family":"Mosbah","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, Faculty of Medicine of Sousse, University of Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaima","family":"Sridi","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Sahloul hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maroua","family":"Saidane","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Belakhdher","sequence":"additional","affiliation":[{"name":"ENT Department, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Chouchene","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imen","family":"Kacem","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maher","family":"Maoua","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Kalboussi","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olfa","family":"El Maalel","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souheil","family":"Chatti","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Kermani","sequence":"additional","affiliation":[{"name":"ENT Department, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrizek","family":"Najib","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine, University Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"27750","reference":[{"key":"10.23749\/mdl.v114i6.14588_ref1","doi-asserted-by":"crossref","unstructured":"Bouaouina N, Ouni S, Belajouza S, et al. 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