{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:08:12Z","timestamp":1788232092155,"version":"build-2803163510"},"reference-count":70,"publisher":"Mattioli1885","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,24]]},"abstract":"<jats:p>Introduction: Benzene is a recognized carcinogen; however, its association with breast cancer is not well established. Hence, a meta-analysis of cohort and case-control studies was performed to determine the association between occupational benzene exposure and the risk of breast cancer. Methods: A systematic literature review identified 7573 publications from which 23 cohort and case-control studies were retained and evaluated using meta-analyses (fixed effects model). PRISMA guidelines were followed. Our protocol was registered in the PROSPERO database (Registration No. CRD42022379720). Study quality was assessed using a modified Newcastle-Ottawa scale (NOS).Results: The summary relative risk (RR) for ever-benzene exposure was 1.08 (95% CI=1.03-1.14, I2=38.6%, n=23 risk estimates); corresponding RR for cancer incidence and mortality were 1.08 (95% CI=1.02-1.14, I2=56.1%, n=16) and 1.10 (95% CI=0.87-1.37, I2&lt;0.001%, n=10). However, heterogeneity was detected for sex (p-het=0.002), publication year (p-het&lt;0.001), study design (p-het&lt;0.001), study quality (p-het&lt;0.001), and industry of employment (p-het=0.03). The RR for high level of exposure showed positive association with breast cancer 1.35 (95% CI=1.06-1.72, I2 =&lt;0.001%, n=3) and (P-het=0.64). Publication bias was detected (p=0.03).Conclusions: The results of our meta-analysis indicate a positive association between occupational benzene exposure and an increased risk of breast cancer, particularly when exposed to higher levels of benzene. However, bias and confounding could not be excluded.<\/jats:p>","DOI":"10.23749\/mdl.v115i5.16306","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T12:58:01Z","timestamp":1741179481000},"page":"e2024034","source":"Crossref","is-referenced-by-count":8,"title":["Occupational Exposure to Benzene and Risk of Breast Cancer: Systematic Review and Meta-Analysis"],"prefix":"10.23749","volume":"115","author":[{"given":"Monireh Sadat","family":"Seyyedsalehi","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Destefano","sequence":"first","affiliation":[{"name":"Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshi","family":"Shah","sequence":"first","affiliation":[{"name":"Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veer","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Bonetti","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boffetta","sequence":"first","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy\/Stony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA\/ Department of Family, Population and Preventive Medicine, Renaissance School of Medicine, Stony Brook Uni-versity, Stony Brook, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"27750","reference":[{"key":"10.23749\/mdl.v115i5.16306_ref1","doi-asserted-by":"crossref","unstructured":"Bray F, Laversanne M, Sung H,et al. 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