{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T05:13:06Z","timestamp":1738386786287,"version":"3.35.0"},"reference-count":29,"publisher":"The Korean Society of Nephrology","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korean Health Industry Development Institute","doi-asserted-by":"crossref","award":["HC20C0085"],"award-info":[{"award-number":["HC20C0085"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["krcp-ksn.org"],"crossmark-restriction":true},"short-container-title":["Kidney Res Clin Pract"],"published-print":{"date-parts":[[2025,1,31]]},"abstract":"<jats:p>Background: Antiviral therapy is an essential treatment for chronic hepatitis B (CHB) infection. Although hypophosphatemia is an important adverse effect of antiviral agents, its clinical significance remains unclear. We investigated the incidence and clinical consequences of hypophosphatemia in a large cohort of CHB patients. Methods: This retrospective cohort study included CHB patients who started antiviral therapy between 2005 and 2015 and continued it for at least 1 year. Patients with decompensated liver cirrhosis, diabetes mellitus, hypertension, concomitant diuretic administration, and end-stage renal disease were excluded. The primary outcome was a change in renal function. Secondary outcomes included the incidence of infection and changes in serum potassium, uric acid, and total carbon dioxide (tCO2). Results: Among the 4,335 patients, hypophosphatemia developed in 75 (1.7%). During the median 2-year follow-up period, patients with hypophosphatemia showed a lower estimated glomerular filtration rate than those in the control group. The incidence of infection and changes in serum potassium, uric acid, and tCO2 were similar between groups. Conclusion: Hypophosphatemia was associated with a renal function decline in patients with CHB receiving antiviral therapy.<\/jats:p>","DOI":"10.23876\/j.krcp.22.197","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:49:42Z","timestamp":1738302582000},"page":"123-131","update-policy":"https:\/\/doi.org\/10.23876\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical consequence of hypophosphatemia during antiviral therapy for chronic hepatitis B"],"prefix":"10.23876","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-1679","authenticated-orcid":true,"given":"Mee Yeon","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-1736","authenticated-orcid":true,"given":"Hojin","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-1162","authenticated-orcid":true,"given":"Kyungho","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2532-0177","authenticated-orcid":true,"given":"Junseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-5215","authenticated-orcid":true,"given":"Minsu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4349-5248","authenticated-orcid":true,"given":"Sang Ah","family":"Chi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0865-2236","authenticated-orcid":true,"given":"Kyunga","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-5554","authenticated-orcid":true,"given":"Dong Hyun","family":"Sinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4387-5291","authenticated-orcid":true,"given":"Jung Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-3450","authenticated-orcid":true,"given":"Geum-Youn","family":"Gwak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-5028","authenticated-orcid":true,"given":"Wooseong","family":"Huh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8176-295X","authenticated-orcid":true,"given":"Yoon-Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9856-6341","authenticated-orcid":true,"given":"Hye Ryoun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9960","reference":[{"key":"ref1","volume-title":"Hepatitis B [Internet]","year":"2024"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.02.010"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i23.2961"},{"key":"ref4","first-page":"1519","volume-title":"Tenofovir effect on the kidneys of HIV-infected patients: a double-edged sword?","author":"Tourret","year":"2013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23044"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12259"},{"key":"ref7","first-page":"273","volume-title":"Tenofovir-induced Fanconi syndrome in a patient with chronic hepatitis B monoinfection","author":"Conti","year":"2016"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.09750913"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(19)30426-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/nejm197406202902504"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024"},{"key":"ref12","first-page":"1081","volume-title":"Hypophosphatemia in patients with hepatitis B virus infection undergoing long-term adefovir dipivoxil therapy","author":"Shimizu","year":"2014"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0779-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000018351"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00866.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3934\/mbe.2020032"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/qai.0b013e3181142f31"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-6-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa011489"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000024416.33113.0a"},{"key":"ref21","first-page":"1909","volume-title":"Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?","author":"Johnson","year":"2005"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000002400"},{"key":"ref23","first-page":"59","volume-title":"Renal and bone toxicity with the use of tenofovir: understanding at the end","author":"Casado","year":"2016"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200109070-00013"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200404300-00019"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-020-00421-6"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.03.001"},{"key":"ref28","first-page":"428","volume-title":"Extrahepatic effects of nucleoside and nucleotide analogues in chronic hepatitis B treatment","author":"Fung","year":"2014"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-012-0384-y"}],"container-title":["Kidney Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/krcp-ksn.org\/upload\/pdf\/j-krcp-22-197.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/krcp-ksn.org\/journal\/view.php?doi=10.23876\/j.krcp.22.197","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/krcp-ksn.org\/upload\/pdf\/j-krcp-22-197.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T05:50:02Z","timestamp":1738302602000},"score":1,"resource":{"primary":{"URL":"http:\/\/krcp-ksn.org\/journal\/view.php?doi=10.23876\/j.krcp.22.197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"URL":"https:\/\/doi.org\/10.23876\/j.krcp.22.197","relation":{},"ISSN":["2211-9140"],"issn-type":[{"value":"2211-9140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"2022-08-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}