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However, there is no consensus regarding its optimal range for patient with chronic kidney disease (CKD). We aimed to analyze the effect of TSAT on the prognosis of patients with non-dialysis CKD (NDCKD). Methods: From 2011 to 2016, 2157 NDCKD patients with baseline TSAT measurements were followed for 10 years. Patients were divided into three groups based on baseline TSAT values: &lt;25%, \u226525% and &lt;45%, and \u226545%. All-cause mortality and 4-point major adverse cardiovascular events (MACE) were analyzed using multivariable Cox regression analysis. Other iron biomarkers and mortality were also analyzed. Results: During a mean follow-up of 7.1 \u00b1 2.9 years, 182 of a total of 2,157 patients (8.4%) died. Compared with the TSAT \u226525% and &lt;45% group, the TSAT &lt;25% group showed significantly increased all-cause mortality (hazard ratio [HR], 1.44; 95% confidence interval (CI), 1.02\u20132.03; p = 0.04). The occurrence of 4-point MACE was significantly increased in univariable analysis in the TSAT &lt;25% group (HR, 1.48; 95% CI, 1.02\u20132.15; p = 0.04), but it was not significant in the multivariable analysis (HR, 1.38; 95% CI, 0.89\u20132.15; p = 0.15). Tertile comparisons of the iron-to-log-ferritin ratio showed increased mortality in the first tertile group. Conclusion: TSAT &lt;25% is an independent risk factor for all-cause mortality in patients with NDCKD and care should be taken to prevent TSAT values of &lt;25%. Other indicators, such as serum iron and iron-to-log-ferritin ratio, may also be used to assess iron deficiency.<\/jats:p>","DOI":"10.23876\/j.krcp.23.278","type":"journal-article","created":{"date-parts":[[2024,5,29]],"date-time":"2024-05-29T05:41:36Z","timestamp":1716961296000},"page":"785-796","update-policy":"https:\/\/doi.org\/10.23876\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The association between transferrin saturation and all-cause mortality in chronic kidney disease: findings from Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease"],"prefix":"10.23876","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4861-7219","authenticated-orcid":true,"given":"Eunmi","family":"Jo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9289-9073","authenticated-orcid":true,"given":"Hyo 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