{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:34:43Z","timestamp":1763706883041,"version":"3.37.3"},"reference-count":30,"publisher":"The Korean Society of Nephrology","issue":"5","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["krcp-ksn.org"],"crossmark-restriction":true},"short-container-title":["Kidney Res Clin Pract"],"published-print":{"date-parts":[[2024,9,30]]},"abstract":"<jats:p>Background: Sacubitril-valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction (HFrEF). However, its long-term protective effects on cardiac function with concurrent acute kidney injury (AKI) remain unclear. This study investigated the recovery of cardiac function relative to kidney function decline. Methods: A total of 512 patients with HFrEF who started sacubitril-valsartan or valsartan treatment were enrolled in cohort 1. Additionally, patients who experienced AKI and underwent follow-up transthoracic echocardiography were enrolled in cohort 2. In cohort 1, short- and long-term kidney outcomes were analyzed. For cohort 2, changes in cardiac function in relation to changes in kidney function after drug initiation were analyzed. Results: The mean age of the patients was 68.3 \u00b1 15.1 years, and 57.4% of the patients were male. AKI occurred in 15.9% of the sacubitril-valsartan group and 12.5% of the valsartan group. After AKI, 78.4% of patients in the sacubitril-valsartan group and 71.4% of those in the valsartan group underwent recovery. Furthermore, cardiovascular outcomes in patients who developed AKI after drug initiation were analyzed in cohort 2. The sacubitril-valsartan group showed a greater improvement in cardiac function compared with the valsartan group (12.4% \u00b1 15.4% vs. 1.4% \u00b1 5.7%, p = 0.046). The ratio of deltas of cardiac and kidney function in the sacubitril-valsartan and valsartan groups were \u20131.76 \u00b1 2.58 and \u20130.20 \u00b1 0.58, respectively (p = 0.03).Conclusion: Patients with HFrEF treated with sacubitril-valsartan exhibited significant improvements in cardiovascular outcomes despite AKI.<\/jats:p>","DOI":"10.23876\/j.krcp.24.021","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T04:21:02Z","timestamp":1727670062000},"page":"614-625","update-policy":"https:\/\/doi.org\/10.23876\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiac and kidney outcomes after sacubitril-valsartan therapy: recovery of cardiac function relative to kidney function decline"],"prefix":"10.23876","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-8473","authenticated-orcid":true,"given":"Hyo Jeong","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-5093","authenticated-orcid":true,"given":"Eunji","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4510-2823","authenticated-orcid":true,"given":"Hee Byung","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1255-1323","authenticated-orcid":true,"given":"Jong Hyun","family":"Jhee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1550-0812","authenticated-orcid":true,"given":"Hyeong Cheon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4245-0339","authenticated-orcid":true,"given":"Hoon Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9960","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac013"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.122.027852"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.06.070"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000664"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2019.04.001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.15829\/1560-4071-2023-5168"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1409077"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-022-07421-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.021459"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-018-0944-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908655"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/circheartfailure.115.002735"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2262"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.04.020"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.08.022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1812851"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.05.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/10742484211058681"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocpiqo.2020.10.008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2022.09.004"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.118.034818"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.604017"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.02.004"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.02.024"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(99)00608-7"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.102.2.203"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.13"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft089"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.048"}],"container-title":["Kidney Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/krcp-ksn.org\/upload\/pdf\/j-krcp-24-021.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/krcp-ksn.org\/journal\/view.php?doi=10.23876\/j.krcp.24.021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/krcp-ksn.org\/upload\/pdf\/j-krcp-24-021.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T04:21:19Z","timestamp":1727670079000},"score":1,"resource":{"primary":{"URL":"http:\/\/krcp-ksn.org\/journal\/view.php?doi=10.23876\/j.krcp.24.021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"URL":"https:\/\/doi.org\/10.23876\/j.krcp.24.021","relation":{},"ISSN":["2211-9140"],"issn-type":[{"type":"electronic","value":"2211-9140"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"2024-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}