{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T05:43:41Z","timestamp":1782798221789,"version":"3.54.5"},"reference-count":40,"publisher":"The Korean Society of Nephrology","issue":"4","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002509","name":"Keimyung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["krcp-ksn.org"],"crossmark-restriction":true},"short-container-title":["Kidney Res Clin Pract"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>Background: Although the relationship between fatty acids (FAs) and the risk of all-cause mortality has been long discussed, there is little evidence about the impact of each FA component on all-cause mortality by kidney function status. Methods: We used data from the U.S. National Health and Nutrition Examination Survey 1999\u20132016. The intake of FAs was estimated as a percentage of total energy using a 1-day 24-hour dietary recall and divided by quartiles; the first quartile was regarded as a reference. We used a multivariate Cox proportional hazard model to identify the impact of FAs on all-cause mortality. Results: Among 44,332 participants, during 129.0 \u00b1 62.4 months of follow-up, there were 1,623 (6.2%), 3,109 (22.3%), and 2,202 deaths (53.1%) in the estimated glomerular filtration rate (eGFR) \u226590, 60\u201390, and &lt;60 mL\/min\/1.73 m2  groups, respectively. Higher intake of SFAs significantly increased the risk of all-cause mortality in participants with eGFR 60\u201390 mL\/min\/1.73 m2  (adjusted hazard ratio, 1.20 in the 4th quartile). Likewise, higher intake of most PUFAs (octadecadienoic acid, octadecatrienoic acid, omega-6, and omega-3) significantly decreased the risk of all-cause mortality in participants with eGFR 60\u201390 mL\/min\/1.73 m2 . These effects of both SFAs and PUFAs were attenuated in participants with eGFR \u226590 and &lt;60 mL\/min\/1.73 m2 . Conclusion: The impact of dietary FAs on all-cause mortality was prominent in participants with eGFR 60\u201390 mL\/min\/1.73 m2 . More specified and targeted counseling for restricting SFAs and encouraging PUFAs needs to be considered, especially for participants with marginally decreased kidney function.<\/jats:p>","DOI":"10.23876\/j.krcp.24.121","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T05:39:02Z","timestamp":1731476342000},"page":"516-529","update-policy":"https:\/\/doi.org\/10.23876\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of dietary fatty acid on all-cause mortality according to the kidney function based on the nationwide population study"],"prefix":"10.23876","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1596-1528","authenticated-orcid":true,"given":"Yaerim","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-2070","authenticated-orcid":true,"given":"Kyungho","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3199-635X","authenticated-orcid":true,"given":"Jeonghwan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6890-4725","authenticated-orcid":true,"given":"Eunjin","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-1260","authenticated-orcid":true,"given":"Jin Hyuk","family":"Paek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-2898","authenticated-orcid":true,"given":"Woo Yeong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7836-8863","authenticated-orcid":true,"given":"Kyubok","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7561-6534","authenticated-orcid":true,"given":"Seungyeup","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5195-7852","authenticated-orcid":true,"given":"Dong Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9123-6542","authenticated-orcid":true,"given":"Chun Soo","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4714-1260","authenticated-orcid":true,"given":"Jung Pyo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"9960","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2013.06.015"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.116046"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2012.04.077"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3945\/an.114.006981"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu13051490"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.29146"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.122671"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3978"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/m13-1788"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27725"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00189.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.121.055560"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.118"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1203859"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1804989"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00630206"},{"key":"ref18","first-page":"447","volume-title":"Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. 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