{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:23:58Z","timestamp":1787293438047,"version":"build-2736575974"},"reference-count":40,"publisher":"The Korean Society of Nephrology","issue":"5","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002560","name":"Soonchunhyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002560","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2019R1G1A1098731"],"award-info":[{"award-number":["NRF-2019R1G1A1098731"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["krcp-ksn.org"],"crossmark-restriction":true},"short-container-title":["Kidney Res Clin Pract"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>Background: The clinical significance of hematuria in immunoglobulin A nephropathy (IgAN) remains unclear. We defined remission of hematuria using stricter yet more intuitive criteria than those in previous studies and evaluated its association with prognosis in IgAN.Methods: This retrospective, multicenter, observational study enrolled 403 patients with IgAN. Hematuria remission was defined as hematuria persisting for at least 3 months before and after diagnostic biopsy, followed by the absence of erythrocytes in four consecutive high-power field microscopic examinations at 3\u20134-month intervals. Clinical outcomes were compared between the hematuria remission (remission) and persistent hematuria (persistent) groups.Results: The mean annual rate of estimated glomerular filtration rate (eGFR) decline was lower in the remission group than in the persistent group (\u20131.51 \u00b1 2.86 vs. \u20132.60 \u00b1 3.18 mL\/min\/1.73 m2\/yr, p = 0.002). In the remission group, the mean annual rate of eGFR decline decreased after hematuria disappearance (from \u20131.28 \u00b1 7.06 to 0.09 \u00b1 0.29 mL\/min\/1.73 m2\/yr, p = 0.02). The proportion of \u226550% decline in eGFR from baseline was also lower in the remission group (p = 0.03). Hematuria remission was an independent prognostic factor of \u226550% decline in eGFR from baseline (hazard ratio, 0.55; 95% confidence interval, 0.33\u20130.99). However, progression to end-stage kidney disease did not differ significantly between two groups (p = 0.08). Similar results were obtained for propensity score matching.Conclusion: Hematuria remission, defined by the newly proposed stricter criteria, could be a potent prognostic factor in IgAN with straightforward applicability in clinical practice.<\/jats:p>","DOI":"10.23876\/j.krcp.25.064","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:18:03Z","timestamp":1783041483000},"page":"702-712","update-policy":"https:\/\/doi.org\/10.23876\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Remission of hematuria is associated with a better prognosis in immunoglobulin A nephropathy"],"prefix":"10.23876","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2707-6238","authenticated-orcid":true,"given":"Geo 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