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The CONVINCE (CONvective VERSus diffusive dialysis in patients with End-stage kidney disease) trial, subsequent meta-analyses, and observational studies indicate that high-dose HDF (\u226523 L convection per session) is associated with improved survival outcomes, particularly through reductions in cardiovascular and possibly also infection-related mortality. Additionally, emerging evidence suggests modest but meaningful benefits in health-related quality of life and symptom control. This comment synthesizes the current literature (2022\u20132025), highlighting clinical outcomes, patient-centered metrics, feasibility, cost-effectiveness, personalized treatment considerations, and implications for clinical practice. Additionally, practical prescription guidance is provided to assist nephrologists in achieving optimal convection volumes and clinical outcomes in routine clinical practice.<\/jats:p>","DOI":"10.23876\/j.krcp.25.179","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:25:23Z","timestamp":1761895523000},"page":"875-879","update-policy":"https:\/\/doi.org\/10.23876\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-volume online hemodiafiltration versus high-flux hemodialysis: a short review of recent evidence and a discussion on clinical implementation"],"prefix":"10.23876","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4289-632X","authenticated-orcid":true,"given":"Peter J.","family":"Blankestijn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9960","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2304820"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)01859-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-024-03934-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.13039"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfac153"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.07.014"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.12.018"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae147"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs530"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv349"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp333"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfv003"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1681\/asn.0000000777"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaf024"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae035"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfac019"}],"container-title":["Kidney Research and Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/krcp-ksn.org\/upload\/pdf\/j-krcp-25-179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/krcp-ksn.org\/journal\/view.php?doi=10.23876\/j.krcp.25.179","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/krcp-ksn.org\/upload\/pdf\/j-krcp-25-179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:25:26Z","timestamp":1761895526000},"score":1,"resource":{"primary":{"URL":"http:\/\/krcp-ksn.org\/journal\/view.php?doi=10.23876\/j.krcp.25.179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"URL":"https:\/\/doi.org\/10.23876\/j.krcp.25.179","relation":{},"ISSN":["2211-9140"],"issn-type":[{"value":"2211-9140","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-01","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}