{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"institution":[{"name":"Swansea University","place":["Swansea"],"department":["Faculty of Medicine, Health and Life Sciences"]}],"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:58:52Z","timestamp":1747209532402,"version":"3.40.5"},"reference-count":0,"publisher":"Swansea University","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Multiple sclerosis (MS) is characterised by demyelination, neuroinflammation and neurodegeneration that contributes to a progressively worsening condition over time. Ongoing, chronic demyelination is an important hallmark of MS pathobiology; however the underlying drivers of progression have not been fully elucidated. Microglia mediate demyelination and contribute to continued lesion expansion.Phagocytosis and processing of myelin by microglia and macrophages results in the release of myelin-lipids \u2013 including cholesterol, and dysregulation of cholesterol homeostasis may drive a damaging microglial\/macrophage response. The oxidised metabolites of cholesterol \u2013 oxysterols \u2013 are important ligands implicated in myelination, neuroinflammation and neuron survival and may represent a druggable target. Little is known about the abundance and location of cholesterol and the oxysterols in the MS brain, or how their dysregulation may contribute to a worsening progressive MS.<\/jats:p>","DOI":"10.23889\/suthesis.66037","type":"dissertation","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T11:34:21Z","timestamp":1712835261000},"approved":{"date-parts":[[2024,2,23]]},"source":"Crossref","is-referenced-by-count":0,"title":["Cholesterol Dysregulation in Multiple Sclerosis: Implications for Pathogenesis and Opportunities for Monitoring and Treating Progressive Disease"],"prefix":"10.23889","author":[{"sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-1368","authenticated-orcid":false,"given":"Kristen","family":"Hawkins","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"9980","container-title":[],"original-title":[],"deposited":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T11:34:23Z","timestamp":1712835263000},"score":1,"degree":["PhD"],"resource":{"primary":{"URL":"https:\/\/cronfa.swan.ac.uk\/Record\/cronfa66037\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[null]]},"references-count":0,"URL":"https:\/\/doi.org\/10.23889\/suthesis.66037","relation":{},"subject":[]}}