{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:48:27Z","timestamp":1777373307718,"version":"3.51.4"},"reference-count":6,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Academic Forensic Pathology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Loeys-Dietz syndrome is a rare autosomal dominant connective tissue disorder with a genetic predisposition to aneurysm formation and congenital cardiofacial defects through genetic mutation affecting the transforming growth factor-beta (TGF\u03b2) signaling pathway. We present a case of a 6-year-old female patient with Loeys-Dietz syndrome who developed an annular aortic valve abscess and ascending aortic dissection due to Staphylococcus aureus endocarditis. Within this case, multiple complications from Loeys-Dietz syndrome were identified, including prosthetic valve infection, aneurysm formation and dissection, septic embolism, and aspiration pneumonia. The clinical presentation, pathologic findings, and pathophysiology will be discussed.<\/jats:p>","DOI":"10.23907\/2016.069","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T10:48:41Z","timestamp":1491907721000},"page":"731-738","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Complex Case of Loeys-Dietz Syndrome: A Case Report and Review of the Literature"],"prefix":"10.1177","volume":"6","author":[{"given":"Tiffany N.","family":"Caza","sequence":"first","affiliation":[{"name":"State University of New York Upstate Medical University - Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Mercedes","sequence":"additional","affiliation":[{"name":"University of Nevada Las Vegas - Cardiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Stoppacher","sequence":"additional","affiliation":[{"name":"Onondaga County Medical Examiner's Office"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles A.","family":"Catanese","sequence":"additional","affiliation":[{"name":"Onondaga County Medical Examiners Office - Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,1]]},"reference":[{"key":"bibr1-2016.069","doi-asserted-by":"crossref","unstructured":"MacCarrickG., BlackJH3rd, BowdinS.  Loeys-Dietz syndrome: a primer for diagnosis and management. Genet Med. 2014 Aug; 16(8): 576\u201387. PMID: 24577266. PMCID: PMC4131122. https:\/\/dx.doi.org\/10.1038\/gim.2014.11.","DOI":"10.1038\/gim.2014.11"},{"key":"bibr2-2016.069","unstructured":"De BackerJ., CampensL., De PaepeA. Genes in thoracic aortic aneurysms\/dissections \u2013 do they matter? Ann Cardiothorac Surg. 2013 Jan; 2(1): 73\u201382. PMID: 23977562. PMCID: PMC3741818. https:\/\/dx.doi.org\/10.3978\/j.issn.2225-319X.2012.12.01."},{"key":"bibr3-2016.069","doi-asserted-by":"crossref","unstructured":"LoeysB.L., DietzH.C. The Loeys-Dietz syndrome. Arch Dis Child. 2007 Feb; 92(2): 119. https:\/\/doi.org\/10.1136\/adc.2006.110593.","DOI":"10.1136\/adc.2006.110593"},{"key":"bibr4-2016.069","doi-asserted-by":"crossref","unstructured":"AalbertsJ.J., Van den BergM.P., BergmanJ.E.  The many faces of aggressive aortic pathology: Loey-Dietz syndrome. Neth Heart J. 2008 Sep; 16(9): 299\u2013304. PMID: 18827873. PMCID: PMC2553155. https:\/\/doi.org\/10.1007\/bf03086168.","DOI":"10.1007\/BF03086168"},{"key":"bibr5-2016.069","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.69.2.223"},{"issue":"2","key":"bibr6-2016.069","first-page":"123","volume":"39","author":"Girgis R.E.","year":"1991","journal-title":"Henry Ford Hosp Med J."}],"container-title":["Academic Forensic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.23907\/2016.069","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.23907\/2016.069","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.23907\/2016.069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:55:14Z","timestamp":1777366514000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.23907\/2016.069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":6,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.23907\/2016.069"],"URL":"https:\/\/doi.org\/10.23907\/2016.069","relation":{},"ISSN":["1925-3621","1925-3621"],"issn-type":[{"value":"1925-3621","type":"print"},{"value":"1925-3621","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12]]}}}