{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:06:05Z","timestamp":1776125165698,"version":"3.50.1"},"reference-count":43,"publisher":"The Japan Society of Coloproctology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Anus Rectum Colon"],"published-print":{"date-parts":[[2022,7,28]]},"DOI":"10.23922\/jarc.2022-002","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T22:10:50Z","timestamp":1658959850000},"page":"181-189","source":"Crossref","is-referenced-by-count":6,"title":["Risk Factors for Predicting Lymph Node Metastasis in Submucosal Colorectal Cancer"],"prefix":"10.23922","volume":"6","author":[{"given":"Kurumi","family":"Tsuchihashi","sequence":"first","affiliation":[{"name":"Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norikatsu","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University"},{"name":"Department of Innovative Oncology Research and Regenerative Medicine, Osaka International Cancer Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiki","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Innovative Oncology Research and Regenerative Medicine, Osaka International Cancer Institute"},{"name":"Department of Surgery, Minoh City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kitakaze","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ohue","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Osaka International Cancer Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuki","family":"Danno","sequence":"additional","affiliation":[{"name":"Department of Innovative Oncology Research and Regenerative Medicine, Osaka International Cancer Institute"},{"name":"Department of Surgery, Minoh City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuko","family":"Nakamichi","sequence":"additional","affiliation":[{"name":"Department of Pathology, Minoh City Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiichi","family":"Morii","sequence":"additional","affiliation":[{"name":"Department of Pathology, Graduate School of Medicine, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichiro","family":"Doki","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Surgery, Graduate School of Medicine, Osaka University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10009","reference":[{"key":"1","unstructured":"1. Colorectal cancer: epidemiology, risk factors, and protective factors [Internet]. [cited 2022 Jan 21]. Available from: https:\/\/www.uptodate.com\/contents\/colorectal-cancer-epidemiology-risk-factors-and-protective-factors."},{"key":"2","unstructured":"2. Japan cancer society [Internet]. [cited 2021 Dec 9]. Available from: https:\/\/www.jcancer.jp\/about_cancer_and_knowledge."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Logan RF, Patnick J, Nickerson C, et al. Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests. Gastroenterology. 2012 Oct; 61 (10): 1439-46.","DOI":"10.1136\/gutjnl-2011-300843"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Saitoh Y, Inaba Y, Sasaki T, et al. Management of colorectal T1 carcinoma treated by endoscopic resection. Dig Endosc. 2016 Apr; 28 (3): 324-9.","DOI":"10.1111\/den.12503"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Aizawa D, Sugino T, Oish T, et al. The essential problem of over-measuring the depth of submucosal invasion in pT1 colorectal cancer. Virchows Archiv. 2022 Feb; 480 (2): 323-33.","DOI":"10.1007\/s00428-021-03221-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nakadoi K, Tanaka S, Kanao H, et al. Management of T1 colorectal carcinoma with special reference to criteria for curative endoscopic resection. J Gastroenterol Hepatol. 2012 Jun; 27 (6): 1057-62.","DOI":"10.1111\/j.1440-1746.2011.07041.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nascimbeni R, Burgart LJ, Nivatvongs S, et al. Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum. 2002 Feb; 45 (2): 200-6.","DOI":"10.1007\/s10350-004-6147-7"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Ricciardi R, Madoff RD, Rothenberger DA, et al. Population-based analyses of lymph node metastases in colorectal cancer. Clin Gastroenterol Hepatol. 2006 Dec; 4 (12): 1522-7.","DOI":"10.1016\/j.cgh.2006.07.016"},{"key":"9","unstructured":"9. Yamamoto S, Watanabe M, Hasegawa H, et al. The risk of lymph node metastasis in T1 colorectal carcinoma. Hepato-Gastroenterology. 2004 Jul-Aug; 51 (58): 998-1000."},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yim K, Won DD, Lee IK, et al. Novel predictors for lymph node metastasis in submucosal invasive colorectal carcinoma. World J Gastroenterol. 2017 Aug; 23 (32): 5936-44.","DOI":"10.3748\/wjg.v23.i32.5936"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Ueno H, Hase K, Hashiguchi Y, et al. Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review. J Gastroenterol. 2014 Sep; 49 (9): 1314-23.","DOI":"10.1007\/s00535-013-0881-3"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. van der Pas MH, Haglind E, Cuesta MA, et al. Laparoscopic versus open surgery for rectal cancer (COLOR II): short-term outcomes of a randomised, phase 3 trial. Lancet Oncol. 2013 Mar; 14 (3): 210-8.","DOI":"10.1016\/S1470-2045(13)70016-0"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Yeh CY, Changchien CR, Wang JY, et al. Pelvic drainage and other risk factors for leakage after elective anterior resection in rectal cancer patients: a prospective study of 978 patients. Ann Surg. 2005 Jan; 241 (1): 9-13.","DOI":"10.1097\/01.sla.0000150067.99651.6a"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. den Dulk M, Marijnen CA, Collette L, et al. Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery. Br J Surg. 2009 Sep; 96 (9): 1066-75.","DOI":"10.1002\/bjs.6694"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Peeters KC, Tollenaar RA, Marijnen CA, et al. Risk factors for anastomotic failure after total mesorectal excision of rectal cancer. Br J Surg. 2005 Feb; 92 (2): 211-6.","DOI":"10.1002\/bjs.4806"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kingham TP, Pachter HL. Colonic anastomotic leak: risk factors, diagnosis, and treatment. J Am Coll Surg. 2009 Feb; 208 (2): 269-78.","DOI":"10.1016\/j.jamcollsurg.2008.10.015"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Papamichael D, Audisio RA, Glimelius B, et al. Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013. Ann Oncol. 2015 Mar; 26 (3): 463-76.","DOI":"10.1093\/annonc\/mdu253"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Juul T, Elfeki H, Christensen P, et al. Normative data for the low anterior resection syndrome score (LARS score). Ann Surg. 2019 Jun; 269 (6): 1124-8.","DOI":"10.1097\/SLA.0000000000002750"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Bryant CLC, Lunniss PJ, Knowles CH, et al. Anterior resection syndrome. Lancet Oncol. 2012 Sep; 13 (9): e403-8.","DOI":"10.1016\/S1470-2045(12)70236-X"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Yasue C, Chino A, Takamatsu M, et al. Pathological risk factors and predictive endoscopic factors for lymph node metastasis of T1 colorectal cancer: a single-center study of 846 lesions. J Gastroenterol. 2019 Aug; 54 (8): 708-17.","DOI":"10.1007\/s00535-019-01564-y"},{"key":"21","unstructured":"21. JMP Statistical Discovery, 1989-2007. SAS: Cary, NC, 2015."},{"key":"22","unstructured":"22. Japanese Society for Cancer of the Colon and Rectum. Japanese Classification of Colorectal Carcinoma. 9th ed. Tokyo: Kanehara; 2018."},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kim B, Kim EH, Park SJ, et al. The risk of lymph node metastasis makes it unsafe to expand the conventional indications for endoscopic treatment of T1 colorectal cancer: a retrospective study of 428 patients. Med (Baltim). 2016 Sep; 95 (37): e4373.","DOI":"10.1097\/MD.0000000000004373"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Asayama N, Oka S, Tanaka S, et al. Long-term outcomes after treatment for T1 colorectal carcinoma. Int J Colorectal Dis. 2016 Mar; 31 (3): 571-8.","DOI":"10.1007\/s00384-015-2473-6"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Guillou PJ, Quirke P, Thorpe H, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005 May; 365 (9472): 1718-26.","DOI":"10.1016\/S0140-6736(05)66545-2"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Yamamoto S, Inomata M, Katayama H, et al. Short-term surgical outcomes from a randomized controlled trial to evaluate laparoscopic and open D3 dissection for stage II\/III colon cancer: Japan Clinical Oncology Group Study JCOG 0404. Ann Surg. 2014 Jul; 260 (1): 23-30.","DOI":"10.1097\/SLA.0000000000000499"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Katsuno H, Shiomi A, Ito M, et al. Comparison of symptomatic anastomotic leakage following laparoscopic and open low anterior resection for rectal cancer: a propensity score matching analysis of 1014 consecutive patients. Surg Endosc. 2016 Jul; 30 (7): 2848-56.","DOI":"10.1007\/s00464-015-4566-2"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ghimire B, Singh YP, Kurlberg G, et al. Comparison of stage and lymph node ratio in young and older patients with colorectal cancer operated in a tertiary hospital in Nepal. J Nepal Health Res Counc. 2018 Mar; 16 (1): 89-92.","DOI":"10.3126\/jnhrc.v16i1.19373"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Kitajima K, Fujimori T, Fujii S, et al. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study. J Gastroenterol. 2004 Jun; 39 (6): 534-43.","DOI":"10.1007\/s00535-004-1339-4"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Kawachi H, Eishi Y, Ueno H, et al. A three-tier classification system based on the depth of submucosal invasion and budding\/sprouting can improve the treatment strategy for T1 colorectal cancer: a retrospective multicenter study. Mod Pathol. 2015 Jun; 28 (6): 872-9.","DOI":"10.1038\/modpathol.2015.36"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wada H, Shiozawa M, Katayama K, et al. Systematic review and meta-analysis of histopathological predictive factors for lymph node metastasis in T1 colorectal cancer. J Gastroenterol. 2015 Jul; 50 (7): 727-34.","DOI":"10.1007\/s00535-015-1057-0"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Miyachi H, Kudo SE, Ichimasa K, et al. Management of T1 colorectal cancers after endoscopic treatment based on the risk stratification of lymph node metastasis. J Gastroenterol Hepatol. 2016 Jun; 31 (6): 1126-32.","DOI":"10.1111\/jgh.13257"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Pai RK, Chen YW, Jakubowski MA, et al. Colorectal carcinomas with submucosal invasion (pT1): analysis of histopathological and molecular factors predicting lymph node metastasis. Mod Pathol. 2017 Jan; 30 (1): 113-22.","DOI":"10.1038\/modpathol.2016.166"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Ha RK, Han KS, Sohn DK, et al. Histopathologic risk factors for lymph node metastasis in patients with T1 colorectal cancer. Ann Surg Treat Res. 2017 Nov; 93 (5): 266-71.","DOI":"10.4174\/astr.2017.93.5.266"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Toh EW, Brown P, Morris E, et al. Area of submucosal invasion and width of invasion predicts lymph node metastasis in pT1 colorectal cancers. Dis Colon Rectum. 2015 Apr; 58 (4): 393-400.","DOI":"10.1097\/DCR.0000000000000315"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Cracco N, Todaro V, Pedrazzi G, et al. The risk of lymph node metastasis in T1 colorectal cancer: new parameters to assess the degree of submucosal invasion. Int J Colorectal Dis. 2021 Jan; 36 (1): 41-5.","DOI":"10.1007\/s00384-020-03738-0"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Nakadoi K, Oka S, Tanaka S, et al. Condition of muscularis mucosae is a risk factor for lymph node metastasis in T1 colorectal carcinoma. Surg Endosc. 2014 Apr; 28 (4): 1269-76.","DOI":"10.1007\/s00464-013-3321-9"},{"key":"38","unstructured":"38. Hashiguchi Y, Muro K, Saito Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 2020 Jan; 25 (1): 1-42."},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Pasic F, Salkic NN. Predictive score for anastomotic leakage after elective colorectal cancer surgery: a decision making tool for choice of protective measures. Surg Endosc. 2013 Oct; 27 (10): 3877-82.","DOI":"10.1007\/s00464-013-2997-1"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Peng J, Ding Y, Tu S, et al. Prognostic nomograms for predicting survival and distant metastases in locally advanced rectal cancers. PLOS ONE. 2014 Aug; 9 (8): e106344.","DOI":"10.1371\/journal.pone.0106344"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Eom BW, Joo J, Kim YW, et al. Nomogram estimating the probability of intraabdominal abscesses after gastrectomy in patients with gastric cancer. J Gastric Cancer. 2015 Dec; 15 (4): 262-9.","DOI":"10.5230\/jgc.2015.15.4.262"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Loupakis F, Moretto R, Aprile G, et al. Clinico-pathological nomogram for predicting BRAF mutational status of metastatic colorectal cancer. Br J Cancer. 2016 Jan 12; 114 (1): 30-6.","DOI":"10.1038\/bjc.2015.399"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Ueno H, Hase K, Hashiguchi Y, et al. Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review. J Gastroenterol. 2014 Sept; 49 (9): 1314-23.","DOI":"10.1007\/s00535-013-0881-3"}],"container-title":["Journal of the Anus, Rectum and Colon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/6\/3\/6_2022-002\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T05:22:04Z","timestamp":1715232124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/6\/3\/6_2022-002\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,28]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.23922\/jarc.2022-002","relation":{},"ISSN":["2432-3853"],"issn-type":[{"value":"2432-3853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,28]]},"article-number":"2022-002"}}