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Association between C-reactive protein-albumin-lymphocyte (CALLY) index and overall survival in patients with colorectal cancer: From the investigation on nutrition status and clinical outcome of common cancers study. Front Immunol. 2023 Mar; 14: 1131496.","DOI":"10.3389\/fimmu.2023.1131496"},{"key":"16","unstructured":"16. Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001; 102 (1): 5-14."},{"key":"17","unstructured":"17. Onodera T, Goseki N, Kosaki G. [Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients]. Nihon Geka Gakkai Zasshi. 1984 Sep; 85 (9): 1001-5."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. O&apos;Gorman P, McMillan DC, McArdle CS. Prognostic factors in advanced gastrointestinal cancer patients with weight loss. Nutr Cancer. 2000; 37 (1): 36-40.","DOI":"10.1207\/S15327914NC3701_4"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kanda Y. Investigation of the freely available easy-to-use software &apos;EZR&apos; for medical statistics. Bone Marrow Transplant. 2013 Mar; 48 (3): 452-8.","DOI":"10.1038\/bmt.2012.244"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Michels KB. The role of nutrition in cancer development and prevention. Int J Cancer. 2005 Mar; 114 (2): 163-5.","DOI":"10.1002\/ijc.20662"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Taniguchi K, Karin M. NF-\u03baB, inflammation, immunity and cancer: coming of age. Nat Rev Immunol. 2018 May; 18 (5): 309-24.","DOI":"10.1038\/nri.2017.142"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lai CC, You JF, Yeh CY, et al. Low preoperative serum albumin in colon cancer: a risk factor for poor outcome. 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