{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T09:01:34Z","timestamp":1764061294395,"version":"3.40.4"},"reference-count":26,"publisher":"The Japan Society of Coloproctology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Anus Rectum Colon"],"published-print":{"date-parts":[[2025,4,25]]},"DOI":"10.23922\/jarc.2024-102","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T22:09:13Z","timestamp":1745532553000},"page":"225-236","source":"Crossref","is-referenced-by-count":1,"title":["Lateral Pelvic Recurrence in Rectal Cancer Is Not Local Recurrence but Lymphatic Metastasis"],"prefix":"10.23922","volume":"9","author":[{"given":"Shigeo","family":"Toda","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"},{"name":"Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Inoshita","sequence":"additional","affiliation":[{"name":"Department of Pathology, Moriyama Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichiro","family":"Matoba","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Hiramatsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudai","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Kuroyanagi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Toranomon Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10009","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med. 2001 Aug;345 (9):638-46.","DOI":"10.1056\/NEJMoa010580"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Abraha I, Aristei C, Palumbo I, et al. Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma. Cochrane Database Syst Rev. 2018 Oct;10:Cd002102.","DOI":"10.1002\/14651858.CD002102.pub3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Fujita S, Mizusawa J, Kanemitsu Y, et al. Mesorectal Excision With or Without Lateral Lymph Node Dissection for Clinical Stage II\/III Lower Rectal Cancer (JCOG0212): A Multicenter, Randomized Controlled, Noninferiority Trial. Ann Surg. 2017 Aug;266 (2):201-7.","DOI":"10.1097\/SLA.0000000000002212"},{"key":"4","unstructured":"4. Hashiguchi Y, Muro K, Saito Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 2020 Jan;25 (1):1-42."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kusters M, Marijnen CA, van de Velde CJ, et al. Patterns of local recurrence in rectal cancer; a study of the Dutch TME trial. Eur J Surg Oncol. 2010 May;36 (5):470-6.","DOI":"10.1016\/j.ejso.2009.11.011"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Enr\u00edquez-Navascu\u00e9s JM, Borda N, Lizerazu A, et al. Patterns of local recurrence in rectal cancer after a multidisciplinary approach. World J Gastroenterol. 2011 Apr;17 (13):1674-84.","DOI":"10.3748\/wjg.v17.i13.1674"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kim TH, Jeong SY, Choi DH, et al. Lateral lymph node metastasis is a major cause of locoregional recurrence in rectal cancer treated with preoperative chemoradiotherapy and curative resection. Ann Surg Oncol. 2008 Mar;15 (3):729-37.","DOI":"10.1245\/s10434-007-9696-x"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Ogura A, Konishi T, Cunningham C, et al. Neoadjuvant (Chemo) radiotherapy With Total Mesorectal Excision Only Is Not Sufficient to Prevent Lateral Local Recurrence in Enlarged Nodes: Results of the Multicenter Lateral Node Study of Patients With Low cT3\/4 Rectal Cancer. J Clin Oncol. 2019 Jan;37 (1):33-43.","DOI":"10.1200\/JCO.18.00032"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Toda S, Kuroyanagi H, Matoba S. Appendix, Colon, and Rectum: Oxford University Press; 2024. Chapter 13, Rectal Cancer Surgery; p. 103-114","DOI":"10.1093\/med\/9780192863584.003.0013"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma: the 3d English Edition [Secondary Publication]. J Anus Rectum Colon. 2019 Oct;3 (4):175-95.","DOI":"10.23922\/jarc.2019-018"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Dworak O, Keilholz L, Hoffmann A. Pathological features of rectal cancer after preoperative radiochemotherapy. Int J Colorectal Dis. 1997;12 (1):19-23.","DOI":"10.1007\/s003840050072"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Nagtegaal ID, Quirke P. What is the role for the circumferential margin in the modern treatment of rectal cancer? J Clin Oncol. 2008 Jan;26 (2):303-12.","DOI":"10.1200\/JCO.2007.12.7027"},{"key":"13","unstructured":"13. Compton CC, Fielding LP, Burgart LJ, et al. Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000 Jul;124 (7):979-94."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ganeshan D, Nougaret S, Korngold E, et al. Locally recurrent rectal cancer: what the radiologist should know. Abdom Radiol (NY). 2019 Nov;44 (11):3709-25.","DOI":"10.1007\/s00261-019-02003-5"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Kanda Y. Investigation of the freely available easy-to-use software &apos;EZR&apos; for medical statistics. Bone Marrow Transplant. 2013 Mar;48 (3):452-8.","DOI":"10.1038\/bmt.2012.244"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Ngan SY, Burmeister B, Fisher RJ, et al. Randomized trial of short-course radiotherapy versus long-course chemoradiation comparing rates of local recurrence in patients with T3 rectal cancer: Trans-Tasman Radiation Oncology Group trial 01.04. J Clin Oncol. 2012 Nov 1;30 (31):3827-33.","DOI":"10.1200\/JCO.2012.42.9597"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Heald RJ, Husband EM, Ryall RD. The mesorectum in rectal cancer surgery--the clue to pelvic recurrence? Br J Surg. 1982 Oct;69 (10):613-6.","DOI":"10.1002\/bjs.1800691019"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Quirke P, Durdey P, Dixon MF, et al. Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet. 1986 Nov;2 (8514):996-9.","DOI":"10.1016\/S0140-6736(86)92612-7"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Quirke P, Steele R, Monson J, et al. Effect of the plane of surgery achieved on local recurrence in patients with operable rectal cancer: a prospective study using data from the MRC CR07 and NCIC-CTG CO16 randomised clinical trial. Lancet. 2009 Mar;373 (9666):821-8.","DOI":"10.1016\/S0140-6736(09)60485-2"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sugihara K, Kobayashi H, Kato T, et al. Indication and benefit of pelvic sidewall dissection for rectal cancer. Dis Colon Rectum. 2006 Nov;49 (11):1663-72.","DOI":"10.1007\/s10350-006-0714-z"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kusters M, Beets GL, van de Velde CJ, et al. A comparison between the treatment of low rectal cancer in Japan and the Netherlands, focusing on the patterns of local recurrence. Ann Surg. 2009 Feb;249 (2):229-35.","DOI":"10.1097\/SLA.0b013e318190a664"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Nakanishi R, Akiyoshi T, Toda S, et al. Radiomics Approach Outperforms Diameter Criteria for Predicting Pathological Lateral Lymph Node Metastasis After Neoadjuvant (Chemo) Radiotherapy in Advanced Low Rectal Cancer. Ann Surg Oncol. 2020 Oct;27 (11):4273-83.","DOI":"10.1245\/s10434-020-08974-w"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Akiyoshi T, Nagata J, Nagasaki T, et al. Laparoscopic salvage lateral pelvic lymph node dissection for locally recurrent rectal cancer. Colorectal Dis. 2015 Oct;17 (10):O213-6.","DOI":"10.1111\/codi.13088"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Al-Sukhni E, Milot L, Fruitman M, et al. Diagnostic accuracy of MRI for assessment of T category, lymph node metastases, and circumferential resection margin involvement in patients with rectal cancer: a systematic review and meta-analysis. Ann Surg Oncol. 2012 Jul;19 (7):2212-23.","DOI":"10.1245\/s10434-011-2210-5"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Group MS. Extramural depth of tumor invasion at thin-section MR in patients with rectal cancer: results of the MERCURY study. Radiology. 2007 Apr;243 (1):132-9.","DOI":"10.1148\/radiol.2431051825"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Matsunaga R, Kojima M, Nishizawa Y, et al. The utility of longitudinal slicing method for rectal specimen: pathological analysis of circumferential resection margin of intersphincteric resection for low-lying rectal cancer. Pathol Int. 2019 May;69 (5):272-81.","DOI":"10.1111\/pin.12797"}],"container-title":["Journal of the Anus, Rectum and Colon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/9\/2\/9_2024-102\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:35:43Z","timestamp":1745642143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/9\/2\/9_2024-102\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.23922\/jarc.2024-102","relation":{},"ISSN":["2432-3853"],"issn-type":[{"type":"electronic","value":"2432-3853"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"article-number":"2024-102"}}