{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:40:37Z","timestamp":1768567237435,"version":"3.49.0"},"reference-count":5,"publisher":"The Japan Society of Coloproctology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Anus Rectum Colon"],"published-print":{"date-parts":[[2025,7,25]]},"DOI":"10.23922\/jarc.2025-032","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T22:12:18Z","timestamp":1753395138000},"page":"368-369","source":"Crossref","is-referenced-by-count":1,"title":["Can Mesenchymal Stem Cell-derived Exosomes Pave the Way Towards Regenerative Medicine Therapeutics in Perianal Fistula with Crohn's Disease?"],"prefix":"10.23922","volume":"9","author":[{"given":"Lan","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Zigong First People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Zigong First People's Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10009","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Takano S, Nakamura Y, Tamaoka K, et al. Management of Anal Fistula with Crohn's Disease. J Anus Rectum Colon. 2025 Jan;9 (1):10-9.","DOI":"10.23922\/jarc.2024-067"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Lotfy A, AboQuella NM, Wang H. Mesenchymal stromal\/stem cell (MSC) -derived exosomes in clinical trials. Stem Cell Res Ther. 2023;14 (1):66.","DOI":"10.1186\/s13287-023-03287-7"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Nazari H, Alborzi F, Heirani-Tabasi A, et al. Evaluating the safety and efficacy of mesenchymal stem cell-derived exosomes for treatment of refractory perianal fistula in IBD patients: clinical trial phase I. Gastroenterol Rep (Oxf). 2022;10:goac075.","DOI":"10.1093\/gastro\/goac075"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Hadizadeh A, Akbari-Asbagh R, Heirani-Tabasi A, et al. Localized Administration of Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Refractory Perianal Fistula in Crohn's Disease Patients: A Phase II Clinical Trial. Dis Colon Rectum. 2024 Dec;67 (12):1564-75.","DOI":"10.1097\/DCR.0000000000003502"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Lu Y, Huangfu S, Ma C, et al. Exosomes derived from umbilical cord mesenchymal stem cells promote healing of complex perianal fistulas in rats. Stem Cell Res Ther. 2024;15 (1):414.","DOI":"10.1186\/s13287-024-04028-0"}],"container-title":["Journal of the Anus, Rectum and Colon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/9\/3\/9_2025-032\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T04:22:59Z","timestamp":1753503779000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/9\/3\/9_2025-032\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,25]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.23922\/jarc.2025-032","relation":{},"ISSN":["2432-3853"],"issn-type":[{"value":"2432-3853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,25]]},"article-number":"2025-032"}}