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Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71 (3):209-49.","DOI":"10.3322\/caac.21660"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kakeji Y, Takahashi A, Hasegawa H, et al. Surgical outcomes in gastroenterological surgery in Japan: Report of the National Clinical Database 2011-2018. Ann Gastroenterol Surg. 2020;4 (3):250-74.","DOI":"10.1002\/ags3.12324"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Matsuda A, Yamada T, Takahashi G, et al. Postoperative infectious complications have a negative oncological impact in patients after stent placement with malignant large bowel obstruction. International Journal of Colorectal Disease. 2023;38 (1):2.","DOI":"10.1007\/s00384-022-04290-9"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lawler J, Choynowski M, Bailey K, et al. 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Annual report on National Clinical Database 2020 for gastroenterological surgery in Japan. Ann Gastroenterol Surg. 2023;7 (3):367-406.","DOI":"10.1002\/ags3.12662"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Yoshida T, Miyata H, Konno H, et al. Risk assessment of morbidities after right hemicolectomy based on the National Clinical Database in Japan. Ann Gastroenterol Surg. 2018;2 (3):220-30.","DOI":"10.1002\/ags3.12067"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Watanabe T, Miyata H, Konno H, et al. Prediction model for complications after low anterior resection based on data from 33,411 Japanese patients included in the National Clinical Database. Surgery. 2017;161 (6):1597-608.","DOI":"10.1016\/j.surg.2016.12.011"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Tsuruta A, Tashiro J, Ishii T, et al. 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Acta Chir Belg. 2021;121 (2):86-93.","DOI":"10.1080\/00015458.2019.1675969"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Evans C, Lim J, Gatzen C, Huang A. Factors influencing laparoscopic colorectal operative duration and its effect on clinical outcome. Surgical Laparoscopy, Endoscopy &amp; Percutaneous Techniques. 2012;22 (5):437-42.","DOI":"10.1097\/SLE.0b013e31826020a3"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. McSorley ST, Tham A, Dolan RD, et al. Perioperative blood transfusion is associated with postoperative systemic inflammatory response and poorer outcomes following surgery for colorectal cancer. Ann Surg Oncol. 2020;27 (3):833-43.","DOI":"10.1245\/s10434-019-07984-7"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Aquina CT, Blumberg N, Becerra AZ, et al. Association among blood transfusion, sepsis, and decreased long-term survival after colon cancer resection. Ann Surg. 2017;266 (2):311-7.","DOI":"10.1097\/SLA.0000000000001990"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Flynn DE, Mao D, Yerkovich ST, et al. The impact of comorbidities on post-operative complications following colorectal cancer surgery. PLOS One. 2020;15 (12):e0243995.","DOI":"10.1371\/journal.pone.0243995"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Shinji S, Ueda Y, Yamada T, et al. Male sex and history of ischemic heart disease are major risk factors for anastomotic leakage after laparoscopic anterior resection in patients with rectal cancer. BMC Gastroenterol. 2018;18 (1):117.","DOI":"10.1186\/s12876-018-0846-3"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Cheng H, Chen BP, Soleas IM, et al. Prolonged Operative Duration Increases Risk of Surgical Site Infections: A Systematic Review. Surg Infect (Larchmt). 2017;18 (6):722-35.","DOI":"10.1089\/sur.2017.089"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Wang DE, Bakshi C, Sugiyama G, et al. Does Operative Time Affect Complication Rate in Laparoscopic Cholecystectomy. Am Surg. 2023;89 (11):4479-84.","DOI":"10.1177\/00031348221117032"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Leong G, Wilson J, Charlett A. Duration of operation as a risk factor for surgical site infection: comparison of English and US data. J Hosp Infect. 2006;63 (3):255-62.","DOI":"10.1016\/j.jhin.2006.02.007"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Algarny S, Perera A, Egenolf P, et al. Postoperative Surgical Site Infections in Spine Surgery: Can the Duration of Surgery Predict the Pathogen Spectrum? In vivo (Athens, Greece). 2023;37 (4):1688-93.","DOI":"10.21873\/invivo.13255"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Araghi M, Soerjomataram I, Bardot A, et al. Changes in colorectal cancer incidence in seven high-income countries: a population-based study. 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Mortality by stage for right- versus left-sided colon cancer: analysis of surveillance, epidemiology, and end results--Medicare data. Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology. 2011;29 (33):4401-9.","DOI":"10.1200\/JCO.2011.36.4414"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Benedix F, Kube R, Meyer F, et al. Comparison of 17,641 patients with right- and left-sided colon cancer: differences in epidemiology, perioperative course, histology, and survival. Diseases of the Colon and Rectum. 2010;53 (1):57-64.","DOI":"10.1007\/DCR.0b013e3181c703a4"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Kvasnovsky CL, Adams K, Sideris M, et al. Elderly patients have more infectious complications following laparoscopic colorectal cancer surgery. Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland. 2016;18 (1):94-100.","DOI":"10.1111\/codi.13109"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Silvestri M, Dobrinja C, Scomersi S, et al. Modifiable and non-modifiable risk factors for surgical site infection after colorectal surgery: a single-center experience. Surgery Today. 2018;48 (3):338-45.","DOI":"10.1007\/s00595-017-1590-y"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Poon JT, Law WL, Wong IW, et al. Impact of laparoscopic colorectal resection on surgical site infection. Annals of Surgery. 2009;249 (1):77-81.","DOI":"10.1097\/SLA.0b013e31819279e3"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wick EC, Hirose K, Shore AD, et al. Surgical site infections and cost in obese patients undergoing colorectal surgery. Archives of Surgery (Chicago, Ill: 1960). 2011;146 (9):1068-72.","DOI":"10.1001\/archsurg.2011.117"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Guillou PJ, Quirke P, Thorpe H, et al. Short-term endpoints of conventional versus laparoscopic-assisted surgery in patients with colorectal cancer (MRC CLASICC trial): multicentre, randomised controlled trial. Lancet. 2005;365 (9472):1718-26.","DOI":"10.1016\/S0140-6736(05)66545-2"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Veldkamp R, Kuhry E, Hop WC, et al. Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. The Lancet Oncology. 2005;6 (7):477-84.","DOI":"10.1016\/S1470-2045(05)70221-7"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Fish EN. The X-files in immunity: sex-based differences predispose immune responses. Nature Reviews Immunology. 2008;8 (9):737-44.","DOI":"10.1038\/nri2394"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Abdullah M, Chai P-S, Chong M-Y, et al. Gender effect on in vitro lymphocyte subset levels of healthy individuals. Cellular Immunology. 2012;272 (2):214-9.","DOI":"10.1016\/j.cellimm.2011.10.009"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Bain BJ, England JM. Normal haematological values: sex difference in neutrophil count. British Medical Journal. 1975;1 (5953):306-9.","DOI":"10.1136\/bmj.1.5953.306"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Ogiso S, Yamaguchi T, Hata H, et al. Evaluation of factors affecting the difficulty of laparoscopic anterior resection for rectal cancer: &quot;narrow pelvis&quot; is not a contraindication. Surgical Endoscopy. 2011;25 (6):1907-12.","DOI":"10.1007\/s00464-010-1485-0"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Zhou XC, Su M, Hu KQ, et al. CT pelvimetry and clinicopathological parameters in evaluation of the technical difficulties in performing open rectal surgery for mid-low rectal cancer. Oncology Letters. 2016;11 (1):31-8.","DOI":"10.3892\/ol.2015.3827"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Falagas ME, Kompoti M. Obesity and infection. Lancet Infect Dis. 2006;6 (7):438-46.","DOI":"10.1016\/S1473-3099(06)70523-0"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Fleischmann E, Kurz A, Niedermayr M, et al. Tissue oxygenation in obese and non-obese patients during laparoscopy. Obesity Surgery. 2005;15 (6):813-9.","DOI":"10.1381\/0960892054222867"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Calu V, Piriianu C, Miron A, et al. Surgical Site Infections in Colorectal Cancer Surgeries: A Systematic Review and Meta-Analysis of the Impact of Surgical Approach and Associated Risk Factors. Life (Basel). 2024;14 (7).","DOI":"10.3390\/life14070850"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Xu Z, Qu H, Kanani G, et al. Update on risk factors of surgical site infection in colorectal cancer: a systematic review and meta-analysis. International Journal of Colorectal Disease. 2020;35 (12):2147-56.","DOI":"10.1007\/s00384-020-03706-8"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Kobayashi H, Asano M, Ishiguro M, et al. Multi-institutional Registry of Large Bowel Cancer in Japan Conducted by the Japanese Society for Cancer of the Colon and Rectum in 2023: Cases Treated in 2015. 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