{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:36:31Z","timestamp":1777095391283,"version":"3.51.4"},"reference-count":37,"publisher":"The Japan Society of Coloproctology","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Anus Rectum Colon"],"published-print":{"date-parts":[[2026,4,25]]},"DOI":"10.23922\/jarc.2025-103","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T22:11:53Z","timestamp":1777068713000},"page":"239-252","source":"Crossref","is-referenced-by-count":0,"title":["Identifying High-risk Patients with Synchronous Colorectal Liver Metastasis: Implications for Preoperative Chemotherapy Selection"],"prefix":"10.23922","volume":"10","author":[{"given":"Keiso","family":"Matsubara","sequence":"first","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiroshima Prefectural Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Onoe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kure Medical Center, National Hospital Organization"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruhiko","family":"Honmyo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hiroshima City North Medical Center Asa Citizens Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Mashima","sequence":"additional","affiliation":[{"name":"Department of Surgery, Onomichi General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Surgery, Chugoku Rosai Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Surgery, Higashihiroshima Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Hattori","sequence":"additional","affiliation":[{"name":"Center for Medical Education, Hiroshima University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohdan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Science, Hiroshima University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10009","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Jegatheeswaran S, Mason JM, Hancock HC, et al. The liver-first approach to the management of colorectal cancer with synchronous hepatic metastases: a systematic review. JAMA Surg. 2013 Apr; 148 (4):385-91.","DOI":"10.1001\/jamasurg.2013.1216"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Fong Y, Fortner J, Sun RL, et al. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999 Sep; 230 (3):309-18; discussion 18-21.","DOI":"10.1097\/00000658-199909000-00004"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial. Lancet. 2008 Mar; 371 (9617):1007-16.","DOI":"10.1016\/S0140-6736(08)60455-9"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Morine Y, Shimada M, Utsunomiya T. Evaluation and management of hepatic injury induced by oxaliplatin-based chemotherapy in patients with hepatic resection for colorectal liver metastasis. Hepatol Res. 2014 Nov; 44 (11):59-69.","DOI":"10.1111\/hepr.12107"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nordlinger B, Sorbye H, Glimelius B, et al. Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2013 Nov; 14 (12):1208-15.","DOI":"10.1016\/S1470-2045(13)70447-9"},{"key":"6","unstructured":"6. Van Cutsem E, Cervantes A, Adam R, et al. ESMO consensus guidelines for the management of patients with metastatic colorectal cancer. Ann Oncol. 2016 Aug; 27 (8):1386-422."},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nordlinger B, Guiguet M, Vaillant JC, et al. Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Francaise de Chirurgie. Cancer. 1996 Apr; 1;77 (7):1254-62.","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1254::AID-CNCR5>3.0.CO;2-I"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Beppu T, Sakamoto Y, Hasegawa K, et al. A nomogram predicting disease-free survival in patients with colorectal liver metastases treated with hepatic resection: multicenter data collection as a Project Study for Hepatic Surgery of the Japanese Society of Hepato-Biliary-Pancreatic Surgery. J Hepatobiliary Pancreat Sci. 2012 Jan; 19 (1):72-84.","DOI":"10.1007\/s00534-011-0460-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Sasaki K, Margonis GA, Andreatos N, et al. The prognostic utility of the &quot;Tumor Burden Score&quot; based on preoperative radiographic features of colorectal liver metastases. J Surg Oncol. 2017 Sep; 116 (6):515-23.","DOI":"10.1002\/jso.24678"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Noda T, Takahashi H, Tei M, et al. Clinical outcomes of neoadjuvant chemotherapy for resectable colorectal liver metastasis with intermediate risk of postoperative recurrence: a multi-institutional retrospective study. Ann Gastroenterol Surg. 2022 Oct; 7 (5):479-90.","DOI":"10.1002\/ags3.12631"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Chen FL, Wang YY, Liu W, et al. Neoadjuvant chemotherapy improves overall survival in resectable colorectal liver metastases patients with high clinical risk scores-- a retrospective, propensity score matching analysis. Front Oncol. 2022 Sep 27;12:973418.","DOI":"10.3389\/fonc.2022.973418"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Margonis GA, Sasaki K, Gholami S, et al. Genetic And Morphological Evaluation (GAME) score for patients with colorectal liver metastases. Br J Surg. 2018 Aug; 105 (9):1210-20.","DOI":"10.1002\/bjs.10838"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Makuuchi M, Kosuge T, Takayama T, et al. Surgery for small liver cancers. Semin Surg Oncol. 1993 Aug; 9 (4):298-304.","DOI":"10.1002\/ssu.2980090404"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Kinugasa Y, Uehara K, Yamaguchi K, et al. Japanese Society for Cancer of the Colon and Rectum. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2024 for the treatment of colorectal cancer. Int J Clin Oncol. 2025 Dec;30 (12):2410-63.","DOI":"10.1007\/s10147-025-02899-8"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Brierley JD, Gospodarowicz MK, Wittekind C. TNM classification of malignant tumours, 8th ed. Hoboken (NJ): Wiley-Blackwell; 2016.","DOI":"10.1002\/9780471420194.tnmc26.pub3"},{"key":"16","unstructured":"16. Lan YT, Chang SC, Lin PC, et al. Clinicopathological and molecular features between synchronous and metachronous metastases in colorectal cancer. Am J Cancer Res. 2011 Apr;11 (4): 1646-58."},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Engstrand J, Nilsson H, Str\u00f6mberg C, et al. Colorectal cancer liver metastases - a population-based study on incidence, management and survival. BMC Cancer 2018 Jan; 18: 78.","DOI":"10.1186\/s12885-017-3925-x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Mekenkamp LJ, Koopman M, Teerenstra S, et al. Clinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastasis. Br J Cancer. 2010 Jul;103 (2):159-64.","DOI":"10.1038\/sj.bjc.6605737"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Koch M, Garden OJ, Padbury R, et al. Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery. Surgery. 2011 May;149 (5):680-88.","DOI":"10.1016\/j.surg.2010.12.002"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Adam R, de Gramont A, Figueras J, et al. Managing synchronous liver metastases from colorectal cancer: a multidisciplinary international consensus. Cancer Treat Rev. 2015 Nov; 41 (9):729-41.","DOI":"10.1016\/j.ctrv.2015.06.006"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nakayama T, Watanabe M, Teramoto T, et al. CA19-9 as a predictor of recurrence in patients with colorectal cancer. J Surg Oncol. 1997 Dec;66 (4):238-43.","DOI":"10.1002\/(SICI)1096-9098(199712)66:4<238::AID-JSO3>3.3.CO;2-F"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Margonis GA, Kim Y, Spolverato G, et al. Association between specific mutations in KRAS codon 12 and colorectal liver metastasis. JAMA Surg. 2015 Aug; 150 (8):722-29.","DOI":"10.1001\/jamasurg.2015.0313"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Vauthey JN, Zimmitti G, Kopetz SE, et al. RAS mutation status predicts survival and patterns of recurrence in patients undergoing hepatectomy for colorectal liver metastases. Ann Surg. 2013 Oct; 258 (4):619-26; discussion 26-7.","DOI":"10.1097\/SLA.0b013e3182a5025a"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Katoh H, Yamashita K, Kokuba Y, et al. Surgical resection of stage IV colorectal cancer and prognosis. World J Surg. 2008 Jun; 32 (6):1130-7.","DOI":"10.1007\/s00268-008-9535-7"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Inoue Y, Hayashi M, Komeda K, et al. Resection margin with anatomic or nonanatomic hepatectomy for liver metastasis from colorectal cancer. J Gastrointest Surg. 2012 Jun; 16 (6):1171-80.","DOI":"10.1007\/s11605-012-1840-7"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Oki E, Ando K, Nakanishi R, et al. Recent advances in treatment for colorectal liver metastasis. Ann Gastroenterol Surg. 2018 Apr;2 (3):167-75.","DOI":"10.1002\/ags3.12071"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Ychou M, Rivoire M, Thezenas S, et al. Chemotherapy (doublet or triplet) plus targeted therapy by RAS status as conversion therapy in colorectal cancer patients with initially unresectable liver- only metastases. The UNICANCER PRODIGE- 14 randomised clinical trial. Br J Cancer. 2022 May;126 (9):1264-70.","DOI":"10.1038\/s41416-021-01644-y"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Javed S, Benoist S, Devos P, et al. Prognostic factors of BRAF V600E colorectal cancer with liver metastases: a retrospective multicentric study. World J Surg Oncol. 2022 Apr;11 20 (1):131.","DOI":"10.1186\/s12957-022-02594-2"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fujiyoshi K, Yamamoto G, Takenoya T, et al. Metastatic pattern of stage IV colorectal cancer with high-frequency microsatellite instability as a prognostic factor. Anticancer Res. 2017 Jan; 37 (1):239-47.","DOI":"10.21873\/anticanres.11313"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Primrose J, Falk S, Finch-Jones M, et al. Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial. Lancet Oncol. 2014 May; 15 (6):601-11.","DOI":"10.1016\/S1470-2045(14)70105-6"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kanemitsu Y, Shimizu Y, Mizusawa J, et al. Hepatectomy followed by mFOLFOX6 versus hepatectomy alone for liver-only metastatic colorectal cancer (JCOG0603): a phase II or III randomized controlled trial. J Clin Oncol. 2021 Dec; 20;39 (36):3789-99.","DOI":"10.1200\/JCO.21.01032"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Hirokawa F, Ueno M, Nakai T, et al. Neoadjuvant chemotherapy versus upfront surgery for resectable liver metastases from colorectal cancer: a multicenter, propensity score-matched cohort study. J Gastrointest Surg. 2022 Apr; 26 (4):772-81.","DOI":"10.1007\/s11605-021-05175-y"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Ayez N, van der Stok EP, Grunhagen DJ, et al. The use of neo-adjuvant chemotherapy in patients with resectable colorectal liver metastases: clinical risk score as possible discriminator. Eur J Surg Oncol. 2015 Jul; 41 (7):859-67.","DOI":"10.1016\/j.ejso.2015.04.012"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Ichida H, Mise Y, Ito H, et al. Optimal indication criteria for neoadjuvant chemotherapy in patients with resectable colorectal liver metastases. World J Surg Oncol. 2019 Jun; 17 (1):100.","DOI":"10.1186\/s12957-019-1641-5"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Ninomiya M, Emi Y, Motomura T, et al. Efficacy of neoadjuvant chemotherapy in patients with high-risk resectable colorectal liver metastases. Int J Clin Oncol. 2021 Dec; 26 (12):2255-64.","DOI":"10.1007\/s10147-021-02024-5"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Beppu T, Yamamura K, Sakamoto K, et al. Validation study of the JSHBPS nomogram for patients with colorectal liver metastases who underwent hepatic resection in the recent era - a nationwide survey in Japan. J Hepatobiliary Pancreat Sci. 2023 May; 30 (5):591-601.","DOI":"10.1002\/jhbp.1256"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Kawazoe T, Nakanishi R, Ando K, et al. Preoperative CT lymph node size as a predictor of nodal metastasis in resectable colon cancer: a retrospective study of 694 patients. BMC Gastroenterol. 2025 Jan;25 (1): 18.","DOI":"10.1186\/s12876-025-03602-x"}],"container-title":["Journal of the Anus, Rectum and Colon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/10\/2\/10_2025-103\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:46:13Z","timestamp":1777092373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/10\/2\/10_2025-103\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,25]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.23922\/jarc.2025-103","relation":{},"ISSN":["2432-3853"],"issn-type":[{"value":"2432-3853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,25]]},"article-number":"2025-103"}}