{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T06:00:45Z","timestamp":1784959245238,"version":"3.55.0"},"reference-count":29,"publisher":"The Japan Society of Coloproctology","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Anus Rectum Colon"],"published-print":{"date-parts":[[2026,7,25]]},"DOI":"10.23922\/jarc.2026-032","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:11:22Z","timestamp":1784931082000},"page":"463-473","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Significance of Lymph Node Count in Colon Cancer Surgery: A Tumour Location-stratified Prognostic Analysis Based on an Integrated Phase-III Randomized Controlled Trial (JCOG2310AS3)"],"prefix":"10.23922","volume":"10","author":[{"given":"Kenta","family":"Iguchi","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery, Kanagawa Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Division of Lower GI, Department of Gastroenterological Surgery, Hyogo Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junki","family":"Mizusawa","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office, National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Aichi Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sano","sequence":"additional","affiliation":[{"name":"Japan Clinical Oncology Group Data Center\/Operations Office, National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kurume University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Niigata Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Kansai Rosai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Ito","sequence":"additional","affiliation":[{"name":"Division of Lower GI, Department of Gastroenterological Surgery, Hyogo Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Suto","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Yamagata Prefectural Central Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, Tochigi Cancer Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Inada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Kochi Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Shimada","sequence":"additional","affiliation":[{"name":"Clinical Oncology Division, Kochi Health Sciences Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Inomata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological and Pediatric Surgery, Oita University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Oncology, Saitama Medical University International Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Takii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Niigata Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuo","family":"Takashima","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Medical Oncology, National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihide","family":"Kanemitsu","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, National Cancer Center Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10009","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Labianca R, Nordlinger B, Beretta GD, et al. Early colon cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Annals of Oncology. 2013;24, DOI: 10.1093\/annonc\/mdt354.","DOI":"10.1093\/annonc\/mdt354"},{"key":"2","unstructured":"2. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL T. American Joint Committee on Cancer (AJCC). Cancer staging manual. 7th ed. American Joint Committee on Cancer: AJCC Cancer Staging Manual 2010:1\u2013648."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Benson AB, Venook AP, Al-Hawary MM, et al. NCCN Guidelines<sup>\u00ae<\/sup> Insights Colon Cancer, Version 2.2018 Featured Updates to the NCCN Guidelines. JNCCN Journal of the National Comprehensive Cancer Network. 2018;16:359\u201369.","DOI":"10.6004\/jnccn.2018.0021"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ramser M, Lobbes LA, Warschkow R, et al. Evaluation of the prognostic relevance of the recommended minimum number of lymph nodes in colorectal cancer\u2014a propensity score analysis. Int J Colorectal Dis. 2021;36:779\u201389.","DOI":"10.1007\/s00384-021-03835-8"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Zambeli-Ljepovi\u0107 A, Hoffman D, Barnes KE, et al. Inadequate Lymph Node Yield: An Inadequate Indication for Adjuvant Chemotherapy in Stage II Colon Cancer. Annals of Surgery Open 2023;4:e338.","DOI":"10.1097\/AS9.0000000000000338"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Lee CHA, Wilkins S, Oliva K, et al. Role of lymph node yield and lymph node ratio in predicting outcomes in non-metastatic colorectal cancer. BJS Open 2019;3:95\u2013105.","DOI":"10.1002\/bjs5.96"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Yuval JB, Thompson HM, Verheij FS, et al. Comparison of Robotic, Laparoscopic, and Open Resections of Nonmetastatic Colon Cancer. Dis Colon Rectum. 2023;66:1347\u201358.","DOI":"10.1097\/DCR.0000000000002637"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Hashiguchi Y, Muro K, Saito Y, et al. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer. Int J Clin Oncol. 2020;25:1\u201342.","DOI":"10.1007\/s10147-019-01485-z"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Scott KWM, Grace RH. Detection of lymph node metastases in colorectal carcinoma before and after fat clearance. British Journal of Surgery. 1989;76:1165\u20137.","DOI":"10.1002\/bjs.1800761118"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Shinto E, Ike H, Hida Jin-ichi, et al. Marked impact of tumor location on the appropriate cutoff values and the prognostic significance of the lymph node ratio in stage III colon cancer: a multi-institutional retrospective analysis. J Gastroenterol. 2019;54:597\u2013607.","DOI":"10.1007\/s00535-018-01539-5"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Iguchi K, Sugiyama A, Mushiake H, et al. True significance of the number of retrieved lymph nodes in stage II colon cancer resected by minimally invasive surgery: Influence of tumor sidedness. Asian J Endosc Surg. 2024;17, DOI: 10.1111\/ases.13312.","DOI":"10.1111\/ases.13312"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Huang Y, Ji L, Zhu J, et al. Lymph node status and its impact on the prognosis of left-sided and right-sided colon cancer: A SEER population-based study. Cancer Med. 2021;10:8708\u201319.","DOI":"10.1002\/cam4.4357"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Yang L, Xiong Z, Xie Q, et al. Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer. BMC Cancer. 2018;18, DOI: 10.1186\/s12885-018-4431-5.","DOI":"10.1186\/s12885-018-4431-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Johnson PM, Porter GA, Ricciardi, R et al. Increasing negative lymph node count is independently associated with improved long-term survival in stage IIIB and IIIC colon cancer. Journal of Clinical Oncology. 2006;24:3570\u20135.","DOI":"10.1200\/JCO.2006.06.8866"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wang J, Kulaylat M, Rockette H, et al. Should total number of lymph nodes be used as a quality of care measure for stage III colon cancer? Ann Surg. 2009;249:559\u201363.","DOI":"10.1097\/SLA.0b013e318197f2c8"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Aan De Stegge WB, Van Leeuwen BL, Elferink MAG, et al. The Evaluation of more lymph nodes in colon cancer is associated with improved survival in patients of all ages. PLoS One. 2016;11, DOI: 10.1371\/journal.pone.0155608.","DOI":"10.1371\/journal.pone.0155608"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Vather R, Sammour T, Kahokehr A, et al. Lymph node evaluation and long-term survival in stage II and stage III colon cancer: A national study. Ann Surg Oncol. 2009;16:585\u201393.","DOI":"10.1245\/s10434-008-0265-8"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Kataoka K, Ouchi A, Suwa Y, et al. Localized colorectal cancer database integrating 4 randomized controlled trials; (JCOG2310A). European Journal of Surgical Oncology. 2024;50, DOI: 10.1016\/j.ejso.2024.108354.","DOI":"10.1016\/j.ejso.2024.108354"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Shimada Y, Hamaguchi T, Mizusawa J, et al. Randomised phase III trial of adjuvant chemotherapy with oral uracil and tegafur plus leucovorin versus intravenous fluorouracil and levofolinate in patients with stage III colorectal cancer who have undergone Japanese D2\/D3 lymph node dissection: Final r. Eur J Cancer. 2014;50:2231\u201340.","DOI":"10.1016\/j.ejca.2014.05.025"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Hamaguchi T, Shimada Y, Mizusawa J, et al. Capecitabine versus S-1 as adjuvant chemotherapy for patients with stage III colorectal cancer (JCOG0910): an open-label, non-inferiority, randomised, phase 3, multicentre trial. Lancet Gastroenterol Hepatol 2018;3:47\u201356.","DOI":"10.1016\/S2468-1253(17)30297-2"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kitano S, Inomata M, Mizusawa J, et al. Survival outcomes following laparoscopic versus open D3 dissection for stage II or III colon cancer (JCOG0404): a phase 3, randomised controlled trial. Lancet Gastroenterol Hepatol. 2017;2:261\u20138.","DOI":"10.1016\/S2468-1253(16)30207-2"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Takii Y, Mizusawa J, Kanemitsu Y, et al. The Conventional Technique Versus the No-touch Isolation Technique for Primary Tumor Resection in Patients with Colon Cancer (JCOG1006): A Multicenter, Open-label, Randomized, Phase III Trial. Ann Surg. 2022;275:849\u201355.","DOI":"10.1097\/SLA.0000000000005241"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Schmoll HJ, Van cutsem E, Stein A, et al. Esmo consensus guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making. Annals of Oncology. 2012;23:2479\u2013516.","DOI":"10.1093\/annonc\/mds236"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Kajiwara T, Nishina T, Yamashita R, et al. Sidedness-Dependent Prognostic Impact of Gene Alterations in Metastatic Colorectal Cancer in the Nationwide Cancer Genome Screening Project in Japan (SCRUM-Japan GI-SCREEN). Cancers (Basel). 2023;15, DOI: 10.3390\/cancers15215172.","DOI":"10.3390\/cancers15215172"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Loree JM, Pereira AAL, Lam M, et al. Classifying colorectal cancer by tumor location rather than sidedness highlights a continuum in mutation profiles and consensus molecular subtypes. Clinical Cancer Research. 2018;24:1062\u201372.","DOI":"10.1158\/1078-0432.CCR-17-2484"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Ouchi A, Sadachi R, Hamaguchi T, et al. Prognostic Relevance of Primary Tumor Sidedness in Early-stage Colorectal Cancer: An Integrated Analysis of 4 Randomized Controlled Trials (JCOG2003A). Ann Surg. 2024;279:283\u20139.","DOI":"10.1097\/SLA.0000000000006076"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Hakki L, Khan A, Gonen M, et al. Lymph Node Metastases and Associated Recurrence-Free Survival in Microsatellite Stable and Unstable Colon Cancer. Ann Surg Oncol. 2023;30:8487\u201394.","DOI":"10.1245\/s10434-023-14270-0"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Belt EJT, Te Velde EA, Krijgsman O, et al. High lymph node yield is related to microsatellite instability in colon cancer. Ann Surg Oncol. 2012;19:1222\u201330.","DOI":"10.1245\/s10434-011-2091-7"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Berg M, Guriby M, Nordg\u00e5rd O, et al. Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers. Molecular Medicine. 2013;19:286\u201393.","DOI":"10.2119\/molmed.2013.00049"}],"container-title":["Journal of the Anus, Rectum and Colon"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/10\/3\/10_2026-032\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:11:19Z","timestamp":1784956279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jarc\/10\/3\/10_2026-032\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,25]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.23922\/jarc.2026-032","relation":{},"ISSN":["2432-3853"],"issn-type":[{"value":"2432-3853","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,25]]},"article-number":"2026-032"}}