{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T06:13:51Z","timestamp":1670307231970},"reference-count":0,"publisher":"Pontifical Catholic University of Sao Paulo (PUC-SP)","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hist. Ciencia Ens."],"abstract":"<jats:p>Resumo \nA incid\u00eancia e mortalidade de cancro da mama t\u00eam vindo a aumentar ao longo dos anos. Esta doen\u00e7a foi descrita pela primeira vez no ano 3000 a.C. por Edwin Smith Papyrus como uma doen\u00e7a grave sem tratamento conhecido. Atualmente, continua a ser necess\u00e1rio o delineamento de estrat\u00e9gias de preven\u00e7\u00e3o, dete\u00e7\u00e3o e tratamento do cancro da mama. Para tal, \u00e9 extremamente importante a utiliza\u00e7\u00e3o de modelos alternativos ao Homem.\nA utiliza\u00e7\u00e3o de animais para fins experimentais iniciou-se h\u00e1 muitos s\u00e9culos (2000 anos a.C.), com os Babil\u00f3nios e os Ass\u00edrios a utilizarem animais para a realiza\u00e7\u00e3o de cirurgias. Os modelos in vitro s\u00e3o relativamente recentes em compara\u00e7\u00e3o com os modelos in vivo, uma vez que a primeira linha celular de cancro da mama (BT-20) foi descoberta apenas em 1958 por Lasfargues e Ozzello. Os modelos in vivo s\u00e3o os mais utilizados pois mimetizam quase na sua totalidade o comportamento da neoplasia no organismo. Em 1965, Howell realizou o primeiro estudo de carcinog\u00e9nese mam\u00e1ria quimicamente induzida em ratos. Posteriormente, surgiu a necessidade da cria\u00e7\u00e3o de animais geneticamente modificados para reduzir ao m\u00e1ximo as diferen\u00e7as nos mecanismos tumorais. Mesmo assim, n\u00e3o \u00e9 poss\u00edvel mimetizar a 100% o processo de carcinog\u00e9nese humano nestes animais devido \u00e0 sua elevada complexidade e n\u00famero limitado de genes.\nAtualmente existe uma diversidade de modelos in vitro e in vivo para o estudo do cancro da mama. A escolha do modelo animal mais adequado \u00e9 um dos passos mais importantes no delineamento experimental. Os objetivos do trabalho e o tipo de dados que poder\u00e3o ser obtidos do modelo animal s\u00e3o aspetos fundamentais a ter em considera\u00e7\u00e3o. Todos os modelos apresentam vantagens e desvantagens e a sua sele\u00e7\u00e3o merece uma reflex\u00e3o cuidada \u00e0 luz dos objetivos do trabalho.\n\u00a0Palavras-chave: Cancro da mama, modelos in vitro, modelos animais.\nAbstract \nThe incidence and mortality of breast cancer has increased over the years. This disease was first described in the year 3000 BC by Edwin Smith Papyrus as a serious disease with no known treatment. Currently the design of strategies for the prevention, detection and treatment of breast cancer remains necessary. For this, it is extremely important to use alternative models to humans.\nThe use of animals for experimental purposes began many centuries ago (2000 years BC), with the Babylonians and the Assyrians using animals to perform surgeries. In vitro models are relatively recent compared to in vivo models, as the first breast cancer cell line (BT-20) was only discovered in 1958 by Lasfargues and Ozzello. In vivo models are the most used as they almost entirely mimic the behavior of the neoplasm in the body. In 1965, Howell performed the first study of chemically induced mammary carcinogenesis in rats. Subsequently, the need arose for the creation of genetically modified animals to reduce as much as possible the differences in tumor mechanisms. Even so, it is not possible to 100% mimic the process of human carcinogenesis in these animals due to their high complexity and limited number of genes. \nCurrently there are a variety of in vitro and in vivo models for the study of breast cancer. Choosing the most suitable animal model is one of the most important steps in the experimental design. The purpose of the work and the type of data that can be obtained from the animal model are fundamental aspects to be considered. All models have advantages and disadvantages, and their selection deserves careful consideration considering the work objectives.\n\u00a0Keywords: Breast cancer, in vitro models, animal models.<\/jats:p>","DOI":"10.23925\/2178-2911.2022v25espp410-420","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T14:32:20Z","timestamp":1670250740000},"page":"410-420","source":"Crossref","is-referenced-by-count":0,"title":["Modelos de cancro da mama: do in vitro para o in vivo"],"prefix":"10.23925","volume":"25","author":[{"given":"Jessica","family":"Silva","sequence":"first","affiliation":[]},{"given":"Ana Isabel","family":"Faustino Rocha","sequence":"additional","affiliation":[]},{"given":"Paula Alexandra","family":"Martins Oliveira","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Alberto","family":"Ramos Duarte","sequence":"additional","affiliation":[]}],"member":"10019","published-online":{"date-parts":[[2022,9,29]]},"container-title":["Hist\u00f3ria da Ci\u00eancia e Ensino: construindo interfaces"],"original-title":[],"link":[{"URL":"https:\/\/revistas.pucsp.br\/index.php\/hcensino\/article\/download\/58774\/40514","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/revistas.pucsp.br\/index.php\/hcensino\/article\/download\/58774\/40514","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T14:32:21Z","timestamp":1670250741000},"score":1,"resource":{"primary":{"URL":"https:\/\/revistas.pucsp.br\/index.php\/hcensino\/article\/view\/58774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.23925\/2178-2911.2022v25espp410-420","relation":{},"ISSN":["2178-2911"],"issn-type":[{"value":"2178-2911","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}