{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:06:00Z","timestamp":1767175560306,"version":"3.48.0"},"reference-count":10,"publisher":"Gobierno de Navarra","issue":"3","license":[{"start":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:00:00Z","timestamp":1764806400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/deed.es"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["An Sist Sanit Navar"],"abstract":"<jats:p>Var\u00f3n de 57 a\u00f1os de edad, fumador, al que se le realiza punci\u00f3n aspiraci\u00f3n con aguja fina guiada por ecobroncoscopia por presentar adenopat\u00edas hipercaptantes en la tomograf\u00eda por emisi\u00f3n de positrones. La citopat\u00f3loga proces\u00f3 in situ extensiones citol\u00f3gicas para evaluaci\u00f3n r\u00e1pida (Diff-Quick) y diferida (Papanicolaou). Con los fragmentos s\u00f3lidos y los co\u00e1gulos obtenidos realiz\u00f3 un bloque celular que se proces\u00f3 como biopsia.\nEn las extensiones se observaron c\u00e9lulas de aspecto histiocitoide con n\u00facleos hendidos, inmunorreactivas para CD68, CD1a, Langerina y S100, con abundantes eosin\u00f3filos; el diagn\u00f3stico final fue de histiocitosis de c\u00e9lulas de Langerhans. El diagn\u00f3stico citol\u00f3gico preciso de esta entidad en ganglios mediast\u00ednicos supone un gran reto. Este caso queremos resaltar que un buen manejo del material por el citopat\u00f3logo presente en la sala es clave para rentabilizar el tejido y poder realizar las t\u00e9cnicas complementarias necesarias para un diagn\u00f3stico completo, evitando abordajes diagn\u00f3sticos m\u00e1s agresivos.<\/jats:p>","DOI":"10.23938\/assn.1137","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T07:20:14Z","timestamp":1764919214000},"page":"e1137","source":"Crossref","is-referenced-by-count":0,"title":["Histiocitosis de c\u00e9lulas de Langerhans diagnosticada en ganglios mediast\u00ednicos mediante punci\u00f3n-aspiraci\u00f3n con aguja fina guiada por ecobroncoscopia","Langerhans cell histiocytosis diagnosed in mediastinal lymph nodes by endoscopic ultrasound-guided fine-needle aspiration"],"prefix":"10.23938","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-5296","authenticated-orcid":false,"given":"Tania","family":"Labiano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3403-5223","authenticated-orcid":false,"given":"Ana","family":"Echegoyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5607-3299","authenticated-orcid":false,"given":"Andreina Stefan\u00eda","family":"De Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-0422","authenticated-orcid":false,"given":"Bego\u00f1a","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Curi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7980-5862","authenticated-orcid":false,"given":"Elena","family":"Almud\u00e9var","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10024","published-online":{"date-parts":[[2025,12,4]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"1. ALLEN CE, MERAD M, MCCLAIN KL. Langerhans-cell histiocytosis. N Engl J Med 2018; 379(9): 856-868. https:\/\/doi.org\/10.1056\/NEJMra1607548","DOI":"10.1056\/NEJMra1607548"},{"key":"ref1","unstructured":"2. YI ES, WEISS LM, GO RS. Haematolymphoid tumours of lung. En: Chan JKC, Wendy A. Cooper (eds). WHO Classification of tumours of the lung, pleura, thymus and heart (5th ed). Lyon (France): International Agency for Research on Cancer; 2021."},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"3. VASSALLO R, HARARI S, TAZI A. Current understanding and management of pulmonary Langerhans cell histiocytosis. Thorax. 2017; 72(10): 937-945. https:\/\/doi.org\/10.1136\/thoraxjnl-2017-210125","DOI":"10.1136\/thoraxjnl-2017-210125"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"4. PHULWARE RH, GULERIA P, IYER VK, BAKHSHI S, SETH R, Mridha AR et al. Cytological diagnosis of Langerhans cell histiocytosis: A series of 47 cases. Cytopathol Off J Br Soc Clin Cytol 2019; 30(4): 413-418. https:\/\/doi.org\/10.1111\/cyt.12709","DOI":"10.1111\/cyt.12709"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"5. ZEPPA P, COZZOLINO I. Fine-needle cytology: Technical procedures and ancillary techniques. Monogr Clin Cytol 2018; 23: 4-13. https:\/\/doi.org\/10.1159\/000478877","DOI":"10.1159\/000478877"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"6. GUPTA A, GUPTA P, GUPTA N, DHOORIA S, VAIDYA PC, PRABHAKAR N et al. Pulmonary Langerhans cell histiocytosis: Diagnosis in bronchoalveolar lavage liquid-based cytology samples. Acta Cytol 2024; 68(4): 379-383. https:\/\/doi.org\/10.1159\/000540011","DOI":"10.1159\/000540011"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"7. KAKKAR S, KAPILA K, VERMA K. Langerhans cell histiocytosis in lymph nodes. Cytomorphologic diagnosis and pitfalls. Acta Cytol 2001; 45(3): 327-332. https:\/\/doi.org\/10.1159\/000327626","DOI":"10.1159\/000327626"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"8. CHAKRABORTY R, BURKE TM, HAMPTON OA, ZINN DJ, LIM KPH, ABHYANKAR H et al. Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis. Blood 2016; 128(21): 2533-2537. https:\/\/doi.org\/10.1182\/blood-2016-08-733790","DOI":"10.1182\/blood-2016-08-733790"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"9. BALLESTER LY, CANTU MD, LIM KPH, SARABIA SF, FERGUSON LS, RENEE WEBB C et al. The use of BRAF V600E mutation-specific immunohistochemistry in pediatric Langerhans cell histiocytosis. Hematol Oncol 2018; 36(1): 307-315. https:\/\/doi.org\/10.1002\/hon.2388","DOI":"10.1002\/hon.2388"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"10. NA JI, KIM JH, KIM HJ, KIM HK, MOON KS, LEE JS et al. VE1 immunohistochemical detection of the BRAF V600E mutation in thyroid carcinoma: a review of its usefulness and limitations. 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