{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:04:07Z","timestamp":1788879847326,"version":"build-2803163510"},"reference-count":0,"publisher":"Health Promotion and Chronic Disease Prevention Branch (HPCDP) Public Health Agency of Canada","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Promot Chronic Dis Prev Can"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<sec>\n         <title>Objective<\/title>\n         <p>To examine the impact of pre-pregnancy diabetes mellitus (DM) on the\npopulation birth prevalence of congenital anomalies in Canada.<\/p>\n       <\/sec>\n       <sec>\n         <title>Methods<\/title>\n         <p>We carried out a population-based study of all women who delivered in\nCanadian hospitals (except those in the province of Quebec) between April 2002 and\nMarch 2013 and their live-born infants with a birth weight of 500 grams or more and\/or a\ngestational age of 22 weeks or more. Pre-pregnancy type 1 or type 2 DM was identified\nusing ICD-10 diagnostic codes. The association between DM and all congenital anomalies\nas well as specific congenital anomaly categories was estimated using adjusted odds\nratios; the impact was calculated as a population attributable risk percent (PAR%).<\/p>\n       <\/sec>\n       <sec>\n         <title>Results<\/title>\n         <p>There were 118 892 infants with a congenital anomaly among 2 839 680 live\nbirths (41.9 per 1000). While the prevalence of any congenital anomaly declined from\n50.7 per 1000 live births in 2002\/03 to 41.5 per 1000 in 2012\/13, the corresponding PAR%\nfor a congenital anomaly related to pre-pregnancy DM rose from 0.6% (95% confidence\ninterval [CI]: 0.4\u20130.8) to 1.2% (95% CI: 0.9\u20131.4). Specifically, the PAR% for congenital\ncardiovascular defects increased from 2.3% (95% CI: 1.7\u20132.9) to 4.2% (95%\nCI: 3.5\u20134.9) and for gastrointestinal defects from 0.8% (95% CI: 0.2\u20131.9) to 1.4%\n(95% CI: 0.7\u20132.6) over the study period.<\/p>\n       <\/sec>\n\t   <sec>\n         <title>Conclusion<\/title>\n         <p>Although there has been a relative decline in the prevalence of congenital\nanomalies in Canada, the proportion of congenital anomalies due to maternal prepregnancy\nDM has increased. Enhancement of preconception care initiatives for women\nwith DM is recommended.<\/p>\n       <\/sec>","DOI":"10.24095\/hpcdp.35.5.01","type":"journal-article","created":{"date-parts":[[2017,4,21]],"date-time":"2017-04-21T13:13:18Z","timestamp":1492780398000},"page":"79-84","source":"Crossref","is-referenced-by-count":40,"title":["Impact of pre-pregnancy diabetes mellitus on congenital anomalies, Canada, 2002\u20132012"],"prefix":"10.24095","volume":"35","author":[{"given":"S","family":"Liu","sequence":"first","affiliation":[{"name":"Maternal, Child & Youth Health Unit, Surveillance and Epidemiology Division, Centre for Chronic Disease Prevention, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Rouleau","sequence":"additional","affiliation":[{"name":"Maternal, Child & Youth Health Unit, Surveillance and Epidemiology Division, Centre for Chronic Disease Prevention, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JA","family":"Le\u00f3n","sequence":"additional","affiliation":[{"name":"Maternal, Child & Youth Health Unit, Surveillance and Epidemiology Division, Centre for Chronic Disease Prevention, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Sauve","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KS","family":"Joseph","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Children's and Women's Hospital of British Columbia, Vancouver, British Columbia, Canada"},{"name":"School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JG","family":"Ray","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Health Policy Management and Evaluation, and Obstetrics and Gynecology, St Michael\u2019s Hospital, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Canadian Perinatal Surveillance System","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10188","container-title":["Health Promotion and Chronic Disease Prevention in Canada"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-35-no-5-2015\/impact-pre-pregnancy-diabetes-mellitus-congenital-anomalies-canada-2002-2012.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T19:39:44Z","timestamp":1512589184000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-35-no-5-2015\/impact-pre-pregnancy-diabetes-mellitus-congenital-anomalies-canada-2002-2012.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":0,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.24095\/hpcdp.35.5.01","archive":["Internet Archive"],"relation":{},"ISSN":["2368-738X"],"issn-type":[{"value":"2368-738X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]}}}