{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:28:50Z","timestamp":1769311730569,"version":"3.49.0"},"reference-count":0,"publisher":"Health Promotion and Chronic Disease Prevention Branch (HPCDP) Public Health Agency of Canada","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Promot Chronic Dis Prev Can"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<sec>\n         <title>Introduction<\/title>\n         <p>Surveillance of childhood cancer incidence trends can inform etiologic\nresearch, policy and programs. This study presents the first population-based report on\ndemographic and geographic variations in incidence trends of detailed pediatric diagnostic\ngroups in Canada.<\/p>\n       <\/sec>\n       <sec>\n         <title>Methods<\/title>\n         <p>The Canadian Cancer Registry data were used to calculate annual age-standardized\nincidence rates (ASIRs) from 1992 to 2010 among children less than\n15 years of age by sex, age and region for the 12 main diagnostic groups and selected\nsubgroups of the International Classification of Childhood Cancer (ICCC), 3rd edition.\nTemporal trends were examined by annual percent changes (APCs) using Joinpoint\nregression.<\/p>\n       <\/sec>\n       <sec>\n         <title>Results<\/title>\n         <p>The ASIRs of childhood cancer among males increased by 0.5% (95% confidence\ninterval (CI) = 0.2\u20130.9) annually from 1992 to 2010, whereas incidence among\nfemales increased by 3.2% (CI = 0.4\u20136.2) annually since 2004 after an initial stabilization.\nThe largest overall increase was observed in children aged 1\u20134 years (APC = 0.9%,\nCI = 0.4\u20131.3). By region, the overall rates increased the most in Ontario from 2006 to\n2010 (APC = 5.9%, CI = 1.9\u201310.1), and increased non-significantly in the other regions\nfrom 1992 to 2010. Average annual ASIRs for all cancers combined from 2006 to 2010\nwere lower in the Prairies (149.4 per million) and higher in Ontario (170.1 per million).\nThe ASIRs increased for leukemias, melanoma, carcinoma, thyroid cancer, ependymomas\nand hepatoblastoma for all ages, and neuroblastoma in 1\u20134 year olds. Astrocytoma\ndecreased in 10\u201314 year olds (APC = \u22122.1%, CI = \u22123.7 to \u22120.5), and among males\n(APC = \u22122.4%, CI = \u22124.6 to \u22120.2) and females (APC = \u22123.7%, CI = \u22125.8 to \u22121.6)\nin Ontario over the study period.<\/p>\n       <\/sec>\n\t   <sec>\n         <title>Conclusion<\/title>\n         <p>Increasing incidence trends for all cancers and selected malignancies are\nconsistent with those reported in other developed countries, and may reflect the\nchanges in demographics and etiological exposures, and artefacts of changes in cancer\ncoding, diagnosis and reporting. Significant decreasing trend for astrocytoma in late\nchildhood was observed for the first time.<\/p>\n       <\/sec>","DOI":"10.24095\/hpcdp.38.3.01","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T18:09:09Z","timestamp":1520618949000},"page":"79-115","source":"Crossref","is-referenced-by-count":39,"title":["Childhood cancer incidence in Canada: demographic and geographic variation of temporal trends (1992\u20132010)"],"prefix":"10.24095","volume":"38","author":[{"given":"Lin","family":"Xie","sequence":"first","affiliation":[{"name":"Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Onysko","sequence":"additional","affiliation":[{"name":"Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard","family":"Morrison","sequence":"additional","affiliation":[{"name":"Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10188","container-title":["Health Promotion and Chronic Disease Prevention in Canada"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-38-no-3-2018\/childhood-cancer-incidence-canada-1992-2010.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T18:09:10Z","timestamp":1520618950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-38-no-3-2018\/childhood-cancer-incidence-canada-1992-2010.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.24095\/hpcdp.38.3.01","archive":["Internet Archive"],"relation":{},"ISSN":["2368-738X"],"issn-type":[{"value":"2368-738X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]}}}