{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:41:37Z","timestamp":1790700097148,"version":"4.1.0"},"reference-count":0,"publisher":"Health Promotion and Chronic Disease Prevention Branch (HPCDP) Public Health Agency of Canada","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Promot Chronic Dis Prev Can"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<sec>\n                    <title>Introduction<\/title>\n                    <p>Several regions in Canada have recently experienced sharp increases in\nopioid overdoses and related hospitalizations and deaths. This paper describes opioid-related\nmortality and disability from opioid use disorder in Canada from 1990 to 2014\nusing data from the Global Burden of Disease (GBD) study.<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Methods<\/title>\n                    <p>We used data from the GBD study to describe temporal trends (1990\u20132014) in\nopioid-related mortality and disability from opioid use disorder using common metrics:\ndisability-adjusted life years (DALY), deaths, years of life lost (YLL) and years lived with\ndisability (YLD). We also compared age-standardized YLL and DALY rates per 100 000\npopulation between Canada, the USA and other regions.<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Results<\/title>\n                    <p>The age-standardized opioid-related DALY rate in Canada was 355.5 per\n100 000 population in 2014, which was higher than the global rate of 193.2, but lower\nthan the rate of 767.9 in the United States. Between 1990 and 2014, the age-standardized\nopioid-related YLL rate in Canada increased by 142.2%, while globally this rate\ndecreased by 10.1%. In comparison with YLL, YLD accounted for a larger proportion of\nthe overall opioid-related burden across all age groups. Health loss was greater for\nmales than females, and highest among those aged 25 to 29 years.<\/p>\n                  <\/sec>\n                  <sec>\n                    <title>Conclusion<\/title>\n                    <p>The health burden associated with opioid-related mortality and disability\nfrom opioid use disorder in Canada is significant and has increased dramatically from\n1990 to 2014. These data point to a need for public health action including enhanced\nmonitoring of a range of opioid-related harms.<\/p>\n                  <\/sec>","DOI":"10.24095\/hpcdp.38.6.03","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T13:22:26Z","timestamp":1528809746000},"page":"234-243","source":"Crossref","is-referenced-by-count":29,"title":["Canadian trends in opioid-related mortality and disability\nfrom opioid use disorder from 1990 to 2014 through the\nlens of the Global Burden of Disease Study"],"prefix":"10.24095","volume":"38","author":[{"given":"Heather M.","family":"Orpana","sequence":"first","affiliation":[{"name":"Public Health Agency of Canada, Ottawa, Ontario, Canada"},{"name":"School of Psychology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin J.","family":"Lang","sequence":"first","affiliation":[{"name":"Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maulik","family":"Baxi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Halverson","sequence":"additional","affiliation":[{"name":"Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Kozloff","sequence":"additional","affiliation":[{"name":"Slaight Family Centre for Youth in Transition, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"},{"name":"Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USA"},{"name":"Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiah","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Patten","sequence":"additional","affiliation":[{"name":"Departments of Community Health Sciences and Psychiatry, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Morrison","sequence":"additional","affiliation":[{"name":"Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10188","container-title":["Health Promotion and Chronic Disease Prevention in Canada"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-38-no-6-2018\/original-quantitative-research-canadian-trends-opioid-related-mortality-disability-1990-2014-lens-global-burden-disease-study.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T13:22:28Z","timestamp":1528809748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-38-no-6-2018\/original-quantitative-research-canadian-trends-opioid-related-mortality-disability-1990-2014-lens-global-burden-disease-study.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":0,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.24095\/hpcdp.38.6.03","archive":["Internet Archive"],"relation":{},"ISSN":["2368-738X"],"issn-type":[{"value":"2368-738X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}