{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:10:31Z","timestamp":1792069831070,"version":"4.4.0"},"reference-count":0,"publisher":"Health Promotion and Chronic Disease Prevention Branch (HPCDP) Public Health Agency of Canada","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Health Promot Chronic Dis Prev Can"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<sec>\t\t\t\n         <title>Introduction<\/title>\t\t\t\n\t\t\t<p>We investigated the prevalence of new or persistent manifestations experienced by COVID-19 survivors at 3 or more months after their initial infection, collectively known as post-COVID-19 condition (PCC).<\/p>\n\t\t<\/sec>\t\n\t<sec>\t\t\n         <title>Methods<\/title>\t\t\t\n\t\t\t<p>We searched four electronic databases and major grey literature resources for prospective studies, systematic reviews, authoritative reports and population surveys. A random-effects meta-analysis pooled the prevalence data of 22 symptoms and outcomes. The GRADE approach was used to assess the certainty of evidence. PROSPERO CRD42021231476.<\/p>\n \t<\/sec>\t\t\n\t<sec>\t\t\n        <title>Results<\/title>\t\t\t\n\t\t\t<p>Of 20 731 identified references, 194 met our inclusion criteria. These studies followed 483 531 individuals with confirmed COVID-19 diagnosis over periods of up to 2 years. Most focused on adults, nearly two-thirds were conducted in Europe and 63% were of high or moderate quality. The supplementary search identified 17 systematic reviews, five authoritative reports and four population surveys that reported on PCC prevalence. Our analysis revealed that more than half of COVID-19 survivors experienced one or more symptoms more than a year after their initial infection. The most common symptoms were fatiguedyspneamemory, sleep or concentration disturbances; depressionand pain. Limitation in returning to work was the most common outcome. Prevalence tended to be higher among females, individuals hospitalized during their initial infection and those who experienced severe COVID-19 illness.<\/p>\n\t\t<\/sec>\t\n\t   <sec>\t\t\n         <title>Conclusion<\/title>\t\t\t\n\t\t\t<p>PCC presents a significant health burden, affecting some groups more than others. This information will help inform health care system policies and services for people living with PCC and those caring for them.<\/p>\n\t\t <\/sec>","DOI":"10.24095\/hpcdp.45.3.02","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:02:49Z","timestamp":1741698169000},"page":"112-138","source":"Crossref","is-referenced-by-count":36,"title":["Global prevalence of post-COVID-19 condition: a systematic review and meta-analysis of prospective evidence"],"prefix":"10.24095","volume":"45","author":[{"given":"Mohamed Kadry","family":"Taher","sequence":"first","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"},{"name":"School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talia","family":"Salzman","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson","family":"Banal","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Morissette","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca R.","family":"Domingo","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Medicine and Joint Department of Medical Imaging, University Health Network and Sinai Health System, University of Toronto, Toronto, Ontario, Canada"},{"name":"Toronto General Hospital Research Institute and Schroeder Arthritis Institute, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curtis L.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of OttawaOttawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Boland","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra M.","family":"Zuckermann","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad A.","family":"Mullah","sequence":"additional","affiliation":[{"name":"Infectious Disease and Vaccination Programs Branch, Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudie","family":"Laprise","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"},{"name":"Department of Social and Preventive Medicine, School of Public Health, Universit\u00e9 de Montr\u00e9al, Montr\u00e9al, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Colonna","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayan","family":"Hashi","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prinon","family":"Rahman","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Collins","sequence":"additional","affiliation":[{"name":"Population Health Modelling Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"Corrin","sequence":"additional","affiliation":[{"name":"Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A.","family":"Waddell","sequence":"additional","affiliation":[{"name":"Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Pagaduan","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rukshanda","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Risk Assessment Division, Centre for Surveillance, Integrated Insights and Risk Assessment, Data, Surveillance and Foresight Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra P.","family":"Jaramillo Garcia","sequence":"additional","affiliation":[{"name":"Evidence Synthesis and Knowledge Translation Unit, Centre for Surveillance and Applied Research, Health Promotion and Chronic Disease Prevention Branch, Public Health Agency of Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10188","updated-by":[{"DOI":"10.24095\/hpcdp.45.6.06","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000}}],"container-title":["Health Promotion and Chronic Disease Prevention in Canada"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-45-no-3-2025\/global-prevalence-post-covid-19-condition-systematic-review-meta-analysis-prospective-evidence.html","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T12:01:11Z","timestamp":1741780871000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.canada.ca\/en\/public-health\/services\/reports-publications\/health-promotion-chronic-disease-prevention-canada-research-policy-practice\/vol-45-no-3-2025\/global-prevalence-post-covid-19-condition-systematic-review-meta-analysis-prospective-evidence.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":0,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.24095\/hpcdp.45.3.02","archive":["Internet Archive"],"relation":{},"ISSN":["2368-738X"],"issn-type":[{"value":"2368-738X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}