{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:32:03Z","timestamp":1773300723447,"version":"3.50.1"},"reference-count":20,"publisher":"Korea Disease Control and Prevention Agency","issue":"1","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["ophrp.org"],"crossmark-restriction":true},"short-container-title":["PHRP"],"published-print":{"date-parts":[[2023,2,28]]},"abstract":"<jats:p>Objectives: On February 16, 2022, 12 cases of hepatitis E virus (HEV) infection were reported in a food manufacturing factory in Korea. The aim of this study was to identify additional cases and to determine the source of this HEV outbreak.Methods: This study was an in-depth investigation of 12 HEV immunoglobulin M (IgM)-positive cases and their demographic, clinical, and epidemiological characteristics. On-site specimens were collected from the environment and from humans, and a follow-up investigation was conducted 2 to 3 months after the outbreak.Results: Among 80 production workers in the factory, 12 (15.0%) had acute HEV infection, all of whom were asymptomatic. The follow-up investigation showed that 3 cases were HEV IgM-positive, while 6 were HEV IgG-positive. HEV genes were not detected in the HEV IgM-positive specimens. HEV genes were not detected in the food products or environmental specimens collected on-site. HEV was presumed to be the causative pathogen. However, it could not be confirmed that the source of infection was common consumption inside the factory.Conclusion: This was the first domestic case of an HEV infection outbreak in a food manufacturing factory in Korea. Our results provide information for the future control of outbreaks and for the preparation of measures to prevent domestic outbreaks of HEV infection.<\/jats:p>","DOI":"10.24171\/j.phrp.2022.0305","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T06:43:47Z","timestamp":1677048227000},"page":"15-22","update-policy":"https:\/\/doi.org\/10.24171\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The first reported hepatitis E outbreak in a food manufacturing factory: Korea, 2022"],"prefix":"10.24171","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1393-6575","authenticated-orcid":true,"given":"Hansol","family":"Yeom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6252-8984","authenticated-orcid":true,"given":"Soonryu","family":"Seo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-4966","authenticated-orcid":true,"given":"Youngsil","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4607-0509","authenticated-orcid":true,"given":"Jaeeun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3543-1826","authenticated-orcid":true,"given":"Myung-Guk","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4481-4789","authenticated-orcid":true,"given":"Deog-Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-0065","authenticated-orcid":true,"given":"Sun-Whan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5815-9319","authenticated-orcid":true,"given":"Song A","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-7990","authenticated-orcid":true,"given":"Sook-Hyang","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-9542","authenticated-orcid":true,"given":"Jin","family":"Gwack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"31909","reference":[{"key":"ref1","volume-title":""},{"key":"ref2","volume-title":""},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.5694\/mja15.00955"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ862"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2022.105083"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.06.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.048"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20364"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.11.005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2013.19.3.309"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-010-0661-9"},{"key":"ref12","first-page":"230","volume-title":"Nine cases of sporadic acute hepatitis E in Korea","author":"Lim","year":"2006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.07.006"},{"key":"ref14","first-page":"517","volume-title":"et al. 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