{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:31:32Z","timestamp":1790253092902,"version":"4.1.0"},"reference-count":46,"publisher":"Korea Disease Control and Prevention Agency","issue":"3","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018688","name":"Korea Disease Control and Prevention Agency","doi-asserted-by":"crossref","award":["6136-303-210-01"],"award-info":[{"award-number":["6136-303-210-01"]}],"id":[{"id":"10.13039\/100018688","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["ophrp.org"],"crossmark-restriction":true},"short-container-title":["PHRP"],"published-print":{"date-parts":[[2024,6,30]]},"abstract":"<jats:p>Objectives: Between July 2, 2021, and September 20, 2022, a Mycobacterium bovis outbreak occurred among exhibition animals at a zoo in the Republic of Korea. This study was conducted to assess the likelihood of M. bovis transmission to human contacts through a contact investigation and to implement preventive treatment for latent tuberculosis infection (LTBI).Methods: In this descriptive study, the Korea Disease Control and Prevention Agency conducted a contact investigation, which included interviews, interferon-gamma release assay (IGRA) tests, and chest X-rays. Contacts underwent IGRA testing on 2 occasions: initial testing of 29 contacts (15 in the first cluster of infection and 14 in the second cluster) and follow-up testing of the 15 contacts in the first cluster.Results: The study included 29 participants, 18 of whom were male (62.1%) and 11 female (37.9%). The mean participant age was 37.3 years (standard deviation, 9.6 years). In the initial IGRA tests, 6 of the 29 participants tested positive, indicating a prevalence of 20.7%. Following prolonged exposure, 1 additional positive case was detected in follow-up testing, raising the prevalence of LTBI to 24.1%. None of the contacts had active tuberculosis. Among the 7 individuals with positive results, 2 (28.6%) underwent treatment for LTBI.Conclusion: This study faced challenges in confirming the transmission of M. bovis infection from infected animals to humans in the Republic of Korea. Nevertheless, adopting a One Health approach necessitates the implementation of surveillance systems and infection control protocols, particularly for occupational groups at high risk of exposure.<\/jats:p>","DOI":"10.24171\/j.phrp.2023.0228","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T07:53:10Z","timestamp":1719474790000},"page":"248-259","update-policy":"https:\/\/doi.org\/10.24171\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Mycobacterium bovis outbreak among exhibition animals at a zoo in the Republic of Korea: the first contact investigation of zoonotic tuberculosis"],"prefix":"10.24171","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5367-4637","authenticated-orcid":true,"given":"Hye Young","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-4626","authenticated-orcid":true,"given":"Yunhyung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-579X","authenticated-orcid":true,"given":"Sang-Eun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4527-0368","authenticated-orcid":true,"given":"Jieun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-730X","authenticated-orcid":true,"given":"Hoyong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"31909","reference":[{"key":"ref1","volume-title":"Global tuberculosis programme: zoonotic TB [Internet]","year":"2017"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(16)30139-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxz002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.20506\/rst.20.1.1263"},{"key":"ref5","first-page":"86","volume-title":"<italic>Mycobacterium bovis<\/italic> in free-living and captive wildlife, including farmed deer","author":"de Lisle","year":"2001"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.02.091"},{"key":"ref7","first-page":"2010","volume-title":"","year":"2009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760170445"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091527"},{"key":"ref10","volume-title":"Global tuberculosis reports 2020 [Internet]","year":"2020"},{"key":"ref11","volume-title":"","year":"2015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/diseases11010039"},{"key":"ref13","first-page":"792","volume-title":"Localized Empyema due to <italic>Mycobacterium bovis<\/italic>","author":"Lim","year":"2011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3904\/kjm.2012.83.4.550"},{"key":"ref15","volume-title":"Korean guideline for national tuberculosis 2023 [Internet]","year":"2022"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.10.0605"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-021-01677-z"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006208"},{"key":"ref19","volume-title":"","year":"2022"},{"key":"ref20","volume-title":"Press release (December 23, 2022) [Internet]","year":"2022"},{"key":"ref21","volume-title":"Infectious Disease Control and Prevention Act, Act No. 13392 (Jan 7, 2016) [Internet]","year":"2016"},{"key":"ref22","volume-title":"Tuberculosis Prevention Act, Act No. 17472 (Sep 12, 2020) [Internet]","year":"2020"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2005.05.002"},{"key":"ref24","volume-title":"Notification of Diagnostic Criteria for Reporting Infectious Disease. Korea Disease Control and Prevention Agency Act 2023-23 (Jan 1, 2024) [Internet]","year":"2023"},{"key":"ref25","volume-title":"Policy and guidelines: defining a tuberculosis cluster or outbreak [Internet]","author":"Denholm","year":"2016"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3201\/eid1703.101550"},{"key":"ref27","volume-title":"Guidelines on the management of latent tuberculosis infection [Internet]","year":"2015"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3904\/kjm.2018.93.6.509"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.02.047"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11091659"},{"key":"ref31","volume-title":"Livestock Products Sanitary Control Act, Act No. 18632 (Dec 21, 2021) [Internet]","year":"2021"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.1066269"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens11101101"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.5145\/acm.2020.23.1.21"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002177"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2019.09.006"},{"key":"ref37","first-page":"924","volume-title":"Bovine tuberculosis: an old disease but a new threat to Africa","author":"Ayele","year":"2004"},{"key":"ref38","first-page":"63","volume-title":"","author":"Drewe","year":"2014"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.4236\/oalib.1102504"},{"key":"ref40","volume-title":"","year":"2008"},{"key":"ref41","volume-title":"Tuberculosis and Brucellosis Prevention Guidelines, Ministry of Agriculture, Food and Rural Affairs 2019-30 (Jul 1, 2019) [Internet]","year":"2019"},{"key":"ref42","volume-title":"1st Comprehensive Zoo Management Plan (2021-2025) [Internet]","year":"2020"},{"key":"ref43","volume-title":"Zoonotic disease (3. Zoonotic tuberculosis) joint epidemiological investigation manual [Internet]","year":"2023"},{"key":"ref44","volume-title":"Tuberculosis Prevention Act, Act No. 19442 (Dec 14, 2023) [Internet]","year":"2023"},{"key":"ref45","volume-title":"Press release (March 24, 2023) [Internet]","year":"2023"},{"key":"ref46","volume-title":"Enforcement Rules of the Tuberculosis Prevention Act, Ministry of Health and Welfare 979 (Dec 1, 2023) [Internet]","year":"2019"}],"container-title":["Osong Public Health and Research Perspectives"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/ophrp.org\/upload\/pdf\/j-phrp-2023-0228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ophrp.org\/journal\/view.php?doi=10.24171\/j.phrp.2023.0228","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/ophrp.org\/upload\/pdf\/j-phrp-2023-0228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T07:54:01Z","timestamp":1719474841000},"score":1,"resource":{"primary":{"URL":"http:\/\/ophrp.org\/journal\/view.php?doi=10.24171\/j.phrp.2023.0228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,30]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"URL":"https:\/\/doi.org\/10.24171\/j.phrp.2023.0228","relation":{},"ISSN":["2210-9099","2233-6052"],"issn-type":[{"value":"2210-9099","type":"print"},{"value":"2233-6052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,30]]},"assertion":[{"value":"2023-08-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-17","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-30","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}