{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:28:55Z","timestamp":1777642135563,"version":"3.51.4"},"reference-count":37,"publisher":"Korea Disease Control and Prevention Agency","issue":"2","license":[{"start":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:00:00Z","timestamp":1773878400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Haiphong University"}],"content-domain":{"domain":["ophrp.org"],"crossmark-restriction":true},"short-container-title":["PHRP"],"published-print":{"date-parts":[[2026,4,30]]},"abstract":"<jats:p>Objectives: This study aimed to determine the prevalence of severe dengue and examine the associations between pre-existing comorbidities and disease severity.Methods: This retrospective study examined patients with dengue fever who received inpatient treatment at a hospital in northern Vietnam between January 1, 2022, and December 30, 2024. Patients were categorized into 2 groups\u2014severe dengue and non-severe dengue\u2014based on the 2009 World Health Organization criteria. Multivariable logistic regression was performed to assess factors associated with severe dengue.Results: Among 3,692 patients, the prevalence of severe dengue was 1.5%. Patients with any pre-existing comorbidity had higher odds of severe dengue compared to those without comorbidities (adjusted odds ratio [aOR], 2.06; 95% confidence interval [CI], 1.20\u20133.53). Having 2 or more comorbidities was also associated with higher odds of severe dengue (aOR, 2.26; 95% CI, 1.18\u20134.33). Among individual conditions, hyperlipidemia was associated with severe dengue (aOR, 2.32; 95% CI, 1.17\u20134.81). Certain combinations of comorbidities, including hypertension with hyperlipidemia (aOR, 2.88; 95% CI, 1.39\u20135.97), hypertension with cardiac disease (aOR, 4.39; 95% CI, 1.30\u201314.79), and hyperlipidemia with cardiac disease (aOR, 4.02; 95% CI, 1.19\u201313.53), were also associated with higher odds of severe dengue.Conclusion: Pre-existing comorbidities, particularly cardiometabolic conditions, were associated with higher odds of severe dengue. Considering comorbidity profiles at hospital admission may help identify patients who require closer clinical monitoring.<\/jats:p>","DOI":"10.24171\/j.phrp.2025.0316","type":"journal-article","created":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:29:47Z","timestamp":1773894587000},"page":"136-144","update-policy":"https:\/\/doi.org\/10.24171\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic and cardiovascular comorbidities as predictors of severe dengue in Vietnamese adults: a retrospective study, 2022\u20132024"],"prefix":"10.24171","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5442-3847","authenticated-orcid":true,"given":"Thang Nhu","family":"Doan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8851-0950","authenticated-orcid":true,"given":"Duc 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