{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:00:41Z","timestamp":1780441241304,"version":"3.54.1"},"reference-count":0,"publisher":"Polish Academy of Sciences Chancellery","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Tooth loss extends beyond oral health concerns, impacting overall well-being and quality of life. It is a global issue, with approximately 7% of individuals aged 20 years or older affected. Research reveals associations between tooth loss and cardiovascular diseases, including hypertension, atherosclerosis, and peripheral arterial disease, attributed mainly to chronic inflammation and altered dietary habits. However, tooth loss has also been associated with cognitive decline, depression, and certain cancers, including lung, head and neck, pancreatic, and esophageal, suggesting the involvement of complex pathophysiological mechanisms that are increasingly the subject of experimental research. In addition, there are psychosocial consequences, such as self-esteem issues and social discomfort. Therefore, it is indisputable that comprehensive oral care is of utmost importance. Recognizing the importance of oral health for overall well-being highlights the necessity for preventative measures and enhanced dental care. As the global population ages, it is increasingly important to comprehend and address the systemic effects of tooth loss. This review aims to summarize the complex pathomechanisms underlying tooth loss and emphasize the need for a comprehensive approach to address its diverse consequences. It advocates for preventive oral health measures to sustain general health and well-being.<\/jats:p>","DOI":"10.24425\/fmc.2024.150139","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T04:55:02Z","timestamp":1726808102000},"page":"25-37","source":"Crossref","is-referenced-by-count":5,"title":["The multifaceted impact of missing teeth on general health: A narrative review"],"prefix":"10.24425","author":[{"given":"Karolina","family":"Kramarczyk","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Jagiellonian University Medical College, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Skowron","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Jagiellonian University Medical College, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Skowron","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Wroclaw Medical University, Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Kaczmarzyk","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Jagiellonian University Medical College, Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"37468","published-online":{"date-parts":[[2024,9,20]]},"container-title":["Folia Medica Cracoviensia"],"original-title":[],"language":"pl","link":[{"URL":"https:\/\/journals.pan.pl\/Content\/132573\/Folia_Medica_2024-1-i-25-37.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:20:30Z","timestamp":1765880430000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pan.pl\/dlibra\/publication\/150139\/edition\/132573\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":0,"URL":"https:\/\/doi.org\/10.24425\/fmc.2024.150139","relation":{},"ISSN":["0015-5616"],"issn-type":[{"value":"0015-5616","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,20]]}}}