{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:28:06Z","timestamp":1765880886318,"version":"3.48.0"},"reference-count":0,"publisher":"Polish Academy of Sciences Chancellery","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Introduction: Basal cell carcinoma (BCC) is the most common skin cancer with increasing prevalence in the last years. The most important risk factor for development of BCC is exposure to UV radiation. Surgical excision remains the first line treatment, but there are some non-surgical methods of treatment. The aim of this study is to present a case of 100-year-old patient with advanced BCC in temporal area who refused surgical treatment. The noninvasive treatment with imiquimod was successful. Case presentation: The 100-year-old male patient was admitted to the dermatological outpatient clinic with an ulceration within the forehead, which had been increasing in size for 3 years. Physical examination revealed shallow irregular ulceration with erythematous pearly-shaped borders in the right temporal area measuring ca. 1.5 cm\u00d72 cm. Dermatoscopic examination of the lesion showed arborising vessels on the semitransparent background, white structureless area and numerous erosions, leading to an initial diagnosis of BCC. Patient refused any surgical interventions within the lesion including skin biopsy. Consequently, treatment with 5% imiquimod was initiated with cream application for 8 weeks, once daily 5 times a week. 8 months after termination of treatment there were no clinical and dermoscopic signs of recurrence of BCC. The patient remains under dermatological follow-up. Conclusions: Imiquimod seemed to be effective and well-tolerated in treatment of advanced BCC in elderly patients and should be considered in case of contraindications to surgery. Patients with history of skin cancer require long-term observation for local recurrence<\/jats:p>","DOI":"10.24425\/fmc.2024.152162","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T04:22:44Z","timestamp":1741062164000},"page":"5-5","source":"Crossref","is-referenced-by-count":0,"title":["Imiquimod as an effective treatment method of advanced basal cell carcinoma affecting 100-year-old man \u2014 case report with literature review"],"prefix":"10.24425","author":[{"given":"Patrycja","family":"Pasieka","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology, University Hospital, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"W\u00f3jtowicz","sequence":"additional","affiliation":[{"name":"Skin Cancer and Melanoma Treatment Center, 5th Military Clinical Hospital in Krakow, Krakow, Poland"},{"name":"Polish Dermatoscopy Group"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Wysocki","sequence":"additional","affiliation":[{"name":"Department of Oncological Surgery, 5th Military Clinical Hospital in Krakow, Krakow, Poland"},{"name":"Chair of Surgery, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland"},{"name":"Maria Sk\u0142odowska-Curie Memorial National Research Institute of Oncology, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Wojas-Pelc","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University Hospital, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej K.","family":"Jaworek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University Hospital, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37468","published-online":{"date-parts":[[2024,12,26]]},"container-title":["Folia Medica Cracoviensia"],"original-title":[],"language":"pl","link":[{"URL":"https:\/\/journals.pan.pl\/Content\/134244\/PDF\/005-016_Folia%20Medica%2003%202024_01.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:20:33Z","timestamp":1765880433000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pan.pl\/dlibra\/publication\/152162\/edition\/134244\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.24425\/fmc.2024.152162","relation":{},"ISSN":["0015-5616"],"issn-type":[{"type":"print","value":"0015-5616"}],"subject":[],"published":{"date-parts":[[2024,12,26]]}}}