{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:35:19Z","timestamp":1765881319732,"version":"3.48.0"},"reference-count":0,"publisher":"Polish Academy of Sciences Chancellery","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Background: Monoclonal gammopathies, including monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM), are plasma-cell disorders linked to profound metabolic remodeling. Lipid metabolism, particularly the balance between n-3 and n-6 polyunsaturated fatty acids (PUFAs), plays a pivotal role in inflammation, membrane dynamics, and tumor progression. Methods: Plasma fatty acid (FA) profiles were analyzed in patients with MGUS, MM, and healthy controls via gas chromatography. Desaturase indices (\u03945D, \u03946D, \u03949SCD1, \u03949SCD2) were calculated from FA ratios. Results: MM patients exhibited significantly higher palmitic acid and lower n-3 PUFA levels (EPA, DHA) compared to controls (p &amp;lt;0.05), reflecting a pro-inflammatory lipid milieu. MGUS patients showed increased oleic acid and markedly elevated \u03949-desaturase activity, suggesting enhanced monounsaturated FA synthesis during early plasma-cell transformation. The n-3\/n-6 ratio decreased progressively from controls (1.0) to MGUS (0.5) and MM (0.4). Trans fatty acids were substantially elevated in MGUS and MM compared to the control group. Conclusion: Altered plasma FA composition and desaturase activity indicate lipid metabolic reprogramming in MGUS and MM. The progressive reduction of the n-3\/n-6 PUFA ratio underscores a shift toward a pro-inflammatory state that may promote malignant transformation. Lipidomic profiling could serve as an early biomarker of disease evolution, and dietary modulation of n-3 PUFAs may hold therapeutic potential.<\/jats:p>","DOI":"10.24425\/fmc.2025.156680","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:29:30Z","timestamp":1765880970000},"page":"19-19","source":"Crossref","is-referenced-by-count":0,"title":["Fatty acids profile in plasma of patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM)"],"prefix":"10.24425","author":[{"given":"Joanna","family":"Gdula-Argasi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Radioligands, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Jurczyszyn","sequence":"additional","affiliation":[{"name":"Department of Hematology, Jagiellonian University Medical College, Krak\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"S\u0142apek","sequence":"additional","affiliation":[{"name":"Department of Radioligands, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Pietrzycka","sequence":"additional","affiliation":[{"name":"Department of Radioligands, Faculty of Pharmacy, Jagiellonian University Medical College, Krakow Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacek","family":"Czepiel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37468","published-online":{"date-parts":[[2025,9,30]]},"container-title":["Folia Medica Cracoviensia"],"original-title":[],"language":"pl","link":[{"URL":"https:\/\/journals.pan.pl\/Content\/137605\/PDF\/019-027-Folia%20Medica%2003-2025-i-2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:30:28Z","timestamp":1765881028000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pan.pl\/dlibra\/publication\/156680\/edition\/137605\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.24425\/fmc.2025.156680","relation":{},"ISSN":["0015-5616"],"issn-type":[{"type":"print","value":"0015-5616"}],"subject":[],"published":{"date-parts":[[2025,9,30]]}}}