{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:14:22Z","timestamp":1783602862912,"version":"3.55.0"},"reference-count":0,"publisher":"Polish Academy of Sciences Chancellery","issue":"1","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["fmc"],"abstract":"<jats:p>Congenital central hypoventilation syndrome (CCHS) and Hirschsprung\u2019s disease (HD) belong to neurocristopathies \u2014 autonomic nervous system defects caused by abnormal neural crest cells migration. Their co-occurrence defines Haddad Syndrome (HS) associated also with increased risk of neural crest origin tumors, mainly neuroblastoma (NBL), and PHOX2B gene mutation. This case concerns a male newborn presenting respiratory failure minutes after birth. Due to sleep apnea and increasing hypercapnia, he required intubation. Genetic testing revealed an anomaly in PHOX2B gene. In subsequent days, the patient did not pass the meconium, which, based on the imaging tests and biopsy, raised a suspicion of HD. The boy was diagnosed with HS and additional diagnostic measures, including cancer screening, were ordered, owing to the syndrome\u2019s characteristics. Awareness of such conditions enables clinicians to implement targeted management that may significantly improve long-term outcomes and quality of life for affected children.<\/jats:p>","DOI":"10.24425\/fmc.2026.158989","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:24:12Z","timestamp":1783599852000},"page":"103-109","source":"Crossref","is-referenced-by-count":0,"title":["Haddad Syndrome \u2014 more than don\u2019t forget to breathe"],"prefix":"10.24425","volume":"66","author":[{"given":"Katarzyna","family":"Kubi\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Milczarek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"37468","published-online":{"date-parts":[[2026,6,11]]},"container-title":["Folia Medica Cracoviensia"],"original-title":[],"link":[{"URL":"https:\/\/wydawnictwo.pan.pl\/index.php\/fmc\/article\/download\/2302\/1733","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/wydawnictwo.pan.pl\/index.php\/fmc\/article\/download\/2302\/1733","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:24:13Z","timestamp":1783599853000},"score":1,"resource":{"primary":{"URL":"https:\/\/wydawnictwo.pan.pl\/index.php\/fmc\/article\/view\/2302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,7,9]]}},"URL":"https:\/\/doi.org\/10.24425\/fmc.2026.158989","relation":{},"ISSN":["0015-5616"],"issn-type":[{"value":"0015-5616","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,11]]}}}