{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T05:21:37Z","timestamp":1734758497707,"version":"3.32.0"},"reference-count":2,"publisher":"Polish Academy of Sciences Chancellery","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The effects of T4 are mainly manifested by positive ino- and chronotropism. The syndrome accompanying hypothyroidism in rabbits (impaired myocardial contractility and reduced ejection capacity) is caused by a deficiency of thyroid hormones - especially T4. The study group consisted of a total of 41 animals: 15 males and 26 females, ranging in age from 2 months to 8 years. with echocardiogram showing reduced fractional shortening (&amp;lt;30%), with normal results of heamatological and biochemical tests. Blood was collected in order to measure T4 level. Echocardiographic examinations were performed with two-dimensional (2D) imaging, M-mode measurements and the pulsed\/colour-labelled Doppler technique. Statistical analysis was performed using Statistica 13.0. Correlations were determined: between serum thyroxine concentration and the value of the fraction of shortening in the groups: young animals (up to 5 years of age) and older animals, females and males, and sterilised and non-sterilised animals. Statistical analysis showed a positive correlation between T4 levels in the blood of the test animals and myocardial fractional shortening and heart rate and left-atrial to aortic ratio (LA\/Ao) in the pre-treatment period. A positive correlation was also shown after dividing the patients into 2 groups based on their age (below 5 years vs. 5 years and over), sex (male and female rabbits) and fact of sterilization (yes\/no). Our study unequivocally confirmed a positive correlation between the decreased serum T4 concentration and reduced fractional shortening, indicating decreased cardiac systolic function in hypothyroid rabbits.<\/jats:p>","DOI":"10.24425\/pjvs.2024.151745","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T20:11:59Z","timestamp":1734725519000},"page":"501-501","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular problems in rabbits in reference to hypothyroidism \u2013 a four-year retrospective study"],"prefix":"10.24425","author":[{"given":"\u0141.","family":"Mazurek","sequence":"first","affiliation":[{"name":"Department of Epizootiology and the Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka 30, 20-612 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Staniec","sequence":"additional","affiliation":[{"name":"Department of Epizootiology and the Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka 30, 20-612 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"\u017b\u00f3\u0142kiewski","sequence":"additional","affiliation":[{"name":"Department of Cattle Breeding and Genetic Resources Conservation, Faculty of Animal Sciences and Bioeconomy, University of Life Sciences in Lublin, 13 Akademicka Street, 20-950 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Skrzypczak","sequence":"additional","affiliation":[{"name":"Second Department of Gynecology, Medical University of Lublin, 20-954 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0141.","family":"Adaszek","sequence":"additional","affiliation":[{"name":"Department of Epizootiology and the Clinic of Infectious Diseases, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, G\u0142\u0119boka 30, 20-612 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37468","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"#cr-split#-ref0.1","unstructured":"Asvold BO, Bjoro T, Nilsen TI, Vatten LJ (2007) Association between blood pressure and serum thyroid-stimulating hormone concentration within the reference range: a population-based study. J Clin Endocrinol Metab 92: 841-845. Biondi B, Cooper DS (2008) The clinical significance of subclinical thyroid dysfunction. Endocr Rev. 29: 76-131. DiGeronimo PM, Brand\u00e3o J (2020) Updates on thyroid disease in rabbits and guinea pigs. Vet Clin North Am Exot Anim Pract 23: 373-381. Gerdes AM, Iervasi G (2010) Thyroid replacement therapy and heart failure. Circulation 122: 385-393. Go\u0142y\u0144ski M (2012) Structure and functions of the thyroid gland - details important for a practicing physician. In: Go\u0142y\u0144ski M (ed) Thyroid diseases in dogs. Elamed, Katowice. Kahaly GJ, Dillmann WH (2005) Thyroid hormone action in the heart. Endocr Rev 26: 704-728. Klein I, Danzi S (2007) Thyroid disease and the heart. Circulation 116: 1725-1735. Rodondi N, Newman AB, Vittinghoff E, de Rekeneire N, Satterfield S, Harris TB, Bauer DC (2005) Subclinical hypothyroidism and the risk of heart failure, other cardiovascular events, and death. Arch Intern Med 165: 2460-2466. Stephan I, Nolte I, Hoppen HO (2003) The effect of hypothyroidism on cardiac function in dogs. Dtsch Tierarztl Wochenschr 110: 231-239. Kopa\u0144ski R (1984) Rational rabbit breeding. PWRiL, Warszawa, p 207. Pas\u0142awska U, Pas\u0142awski R, Nowak K, P\u0142\u00f3ciennik M (2020) The effect of hypothyroidism on the circulatory system in dogs. Wet w prakt 17: 37-42. Pingitore A, Galli E, Barison A, Iervasi A, Scarlattini M, Nucci D, L'abbate A, Mariotti R, Iervasi G (2008) Acute effects of triiodothyronine (T3) replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study. J Clin Endocrinol Metab 93: 1351-1358. Tilley LP, Smith FWK, Oyama M, Sleeper MM (2010) Cardiology of dogs and cats. ed., Edra Urban &amp"},{"key":"#cr-split#-ref0.2","doi-asserted-by":"crossref","unstructured":"Partner, p 269. Zi\u0119tek J, Wilczy\u0144ska A, Jab\u0142o\u0144ski M, Sajdak S, Romanowska A, Teodorowski O, Mazurek \u0141, Staniec M, Winiarczyk S, Adaszek \u0141 (2021) Clinical problems in small mammals: Eleven-year retrospective study. Med Weter 77: 95-98.","DOI":"10.21521\/mw.6502"}],"container-title":["Polish Journal of Veterinary Sciences"],"original-title":[],"language":"pl","link":[{"URL":"https:\/\/journals.pan.pl\/Content\/133628\/PDF\/2%20_%20Mazurek.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T20:12:13Z","timestamp":1734725533000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pan.pl\/dlibra\/publication\/151745\/edition\/133628\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":2,"URL":"https:\/\/doi.org\/10.24425\/pjvs.2024.151745","relation":{},"ISSN":["1505-1773"],"issn-type":[{"value":"1505-1773","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}