{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:23:42Z","timestamp":1793748222123,"version":"4.6.1"},"reference-count":1,"publisher":"Polish Academy of Sciences Chancellery","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Foot and mouth disease (FMD) is an acute viral disease in animals. Inactive parapoxvirus ovis (IPPVO) strengthens humoral immunity. This study aimed to determine the effect of IPPVO application together with FMD vaccine on cattle immunity. It included 30 Holstein cattle randomly divided into two groups: one was administered only the FMD vaccine, and the other was administered the FMD vaccine and IPPVO simultaneously. Control blood was collected from all animals at 0 hours. Serum TNF-\u03b1, IL-1\u03b2, and IL-6 levels were measured in blood samples collected at 4, 8, 12, 16, and 24 hours post-vaccination, while serum IgG and IgM levels were measured in blood samples collected at 4, 8, 12, 16, and 20 days post-vaccination using ELISA kits. While no changes in serum TNF-\u03b1, IL-1\u03b2, and IL-6 levels were detected in the FMD group, IL-1\u03b2 levels significantly increased (peaking at four hours) in the FMD + IPPVO group. In the FMD group, while IgG levels increased significantly (peaking at 16 days), IgM levels did not change. In the FMD + IPPVO group, IgG level on day 8 days was higher than the 16 days value. Also, the IgM level increased significantly on day 16. In conclusion, the application of FMD with IPPVO increases the primary immune response (IgM), but it does not effect the long-term immune response (IgM).<\/jats:p>","DOI":"10.24425\/pjvs.2025.154941","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:58:29Z","timestamp":1750143509000},"page":"225-231","source":"Crossref","is-referenced-by-count":1,"title":["Effects of coadministration of foot and mouth disease vaccine and inactivated parapoxvirusovis on humoral immunity in cattle"],"prefix":"10.24425","author":[{"given":"R.","family":"Canbar","sequence":"first","affiliation":[{"name":"Aksaray University, Faculty of Veterinary, Department of Pharmacology and Toxicology. Aksaray, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Uslu","sequence":"additional","affiliation":[{"name":"Yozgat Bozok University, Department of Laboratory and Veterinary Health,Sefaatli Vocational College, Yozgat, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"37468","published-online":{"date-parts":[[2025,6,13]]},"reference":[{"key":"ref0","unstructured":"Abdullah KMA (2016) The effect of immunstimulant drugs used together with fmd vaccine on immunoglobulins in sheep. (Phd thesis). Y\u00fcz\u00fcnc\u00fc Y\u0131l Univ., Graduate School of Health Sciences, Dep. of Internal Medicine: 49. Akdo\u011fan M, Y\u00f6ntem M (2018) Cytokines. Online Turkish Journal of Health Sciences 3: 36-45. Anziliero D, Weiblen R, Kreutz L, Spilki F, Flores E (2014) Inactivated Parapoxvirus ovis induces a transient increase in the expression of proinflammatory, Th1-related, and autoregulatory cytokines in mice. 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Eur Rev Med Pharmacol Sci 21: 3459-3464. &nbsp; &nbsp;"}],"container-title":["Polish Journal of Veterinary Sciences"],"original-title":[],"language":"pl","link":[{"URL":"https:\/\/journals.pan.pl\/Content\/135321\/PDF\/6%20_%20Canbar.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T06:58:29Z","timestamp":1750143509000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pan.pl\/dlibra\/publication\/154941\/edition\/135321\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,13]]},"references-count":1,"URL":"https:\/\/doi.org\/10.24425\/pjvs.2025.154941","relation":{},"ISSN":["1505-1773"],"issn-type":[{"value":"1505-1773","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,13]]}}}