{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T10:16:51Z","timestamp":1758190611976,"version":"3.44.0"},"reference-count":2,"publisher":"Polish Academy of Sciences Chancellery","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The resistance of strongyles to pyrantel pamoate has been reported in publications worldwide. There is no data on its efficacy in horses in Poland. Therefore, the aim of this study was to evaluate the effectiveness of pyrantel pamoate to control strongyle invasions in young horses. The study involved horses of both sexes, aged 1 to 2 years, and was conducted in two seasons (spring and the end of summer). Feces were collected 24 hours before and 14 days after deworming, and they were then examined using McMaster\u2019s and combined sedimentation-flotation methods. Results revealed that in spring, the average eggs per gram (EPG) before deworming was 1354.54, but after the treatment EPG was 485, and fecal egg count reduction test (FECRT) = 67.45%. Considering the age groups of the horses, the average EPG for one-year-olds was 1565.38, and 1050 for two-year-olds, respectively. The FECRT for strongyle invasions was 69.78% in one-year-old and 62.43% in two-year-old horses. At the end of summer, the average EPG was 1954.54 before deworming, and after the treatment, strongyle eggs were found in only two horses, and FECRT was 99.53%. Considering the age groups of horses before deworming, the average EPG in one-year-olds was 2103.85, but was 1738.89 in two-year-old horses. The FECRT values were 99.27 and 100%, respectively. The results revealed a quite limited efficacy of pyrantel pamoate in the deworming of Strongylidae invasions in young (one- and two-year-old horses) during the spring season. According to WAAVP recommendations, this was assumed to be the result of pyrantel pamoate resistance of Strongylidae nematodes in horses. In contrast, treatment using the same compound in the same age horses, but conducted at the end of summer, was found satisfactory. This was the first study concerning pyrantel pamoate efficacy in horses in Poland.<\/jats:p>","DOI":"10.24425\/pjvs.2025.156069","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T08:27:26Z","timestamp":1758097646000},"page":"441-441","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of the antiparasitic effectiveness of pyrantel pamoate in treatment of Strongylidae invasions in young horses \u2013 preliminary studies"],"prefix":"10.24425","author":[{"given":"M.","family":"Studzi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Parasitology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Klockiewicz","sequence":"additional","affiliation":[{"name":"Department of Pre-clinical Sciences, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Ciszewskiego 8, 02-786 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Szczepaniak","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Demkowska-Kutrzepa","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rocze\u0144-Karczmarz","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tomczuk","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Fish Diseases, Faculty of Veterinary Medicine, University of Life Sciences, Akademicka 12, 20-033 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37468","published-online":{"date-parts":[[2025,9,16]]},"reference":[{"key":"#cr-split#-ref0.1","unstructured":"Cer\u0148ansk\u00e1 D, Paoletti B, Kr\u00e1\u013eov\u00e1-Hromadov\u00e1 I, Iorio R, Cudekov\u00e1 P, Milillo P, Traversa D (2009) Application of a Reverse Line Blot hybridisation assay for the speciesspecific identification of cyathostomins (Nematoda Strongylida) from benzimidazole-treated horses in n the Slovak Republic. Vet Parasitol 160: 171-174. Corning S (2009) Equine cyathostomins: a review of biology, clinical significance and therapy. Parasit Vectors 2(2): S1. Craven J, Bjorn H, Henriksen SA, Nansen P, Larsen M, Lendal S (1998) Survey of anthelmintic resistance on Danish horse farms, using 5 different methods of calculating faecal egg count reduction. Equine Vet J 30: 289-293. Dauparait\u0117 E, Kup\u010dinskas T, von Samson-Himmelstjerna G, Petkevi\u010dius S (2021) Anthelmintic resistance of horse strongyle nematodes to ivermectin and pyrantel in Lithuania. Acta Vet Scand 63: 5. Denwood MJ, Innocent GT, Prentice JC, Matthews L, Reid SW, Pipper CB, Levecke B, Kaplan RM, Kotze AC, Keiser J, Palmeirim M, McKendrick IJ (2019) A hypothesis testing framework for the ratio of means of two negative binomial distributions: classifying the efficacy of anthelmintic treatment against intestinal parasites. arXiv: 1910.06667. Denwood MJ, Kaplan RM, McKendrick IJ, Thamsborg SM, Nielsen MK, Levecke B (2023) A statistical framework for calculating prospective sample sizes and classifying efficacy results for faecal egg count reduction tests in ruminants, horses and swine. Vet Parasitol 314: 109867. Gawor J, Korna\u015b S, Charcenko V, Nowosad B, Skalska M (2006) Intestinal parasites and health problems in horses in different breeding systems. Med Weter 62: 331-334. Gund\u0142ach JL, Sadzikowski AB, Tomczuk K, Studzi\u0144ska MB (2004). Parasites of the alimentary tract of horses from the Lublin district in the light of coproscopic and gross anatomopatological examinations. Med Weter 60: 1089-1092. Ihler CF (1995) A field survey on anthelmintic resistance in equine small strongyles in Norway. Acta Vet Scand 36: 135-143. Kaplan RM, Denwood MJ, Nielsen MK, Thamsborg SM, Torgerson PR, Gilleard JS, Dobson RJ, Vercruysse J, Levecke B (2023) World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guideline for diagnosing anthelmintic resistance using the faecal egg count reduction test in ruminants, horses and swine. Vet Parasitol 318: 109936. Kaplan RM, Klei TR, Lyons ET, Lester G, Courtney CH, French DD, Tolliver SC, Vidyashankar AN, Zhao Y (2004) Prevalence of anthelmintic resistant cyathostomes on horse farms. J Am Vet Med Assoc 225: 903-910. Kaplan RM, Nielsen MK (2010) An evidence\u2010based approach to equine parasite control: It ain't the 60s anymore. Equine Vet Educ 22: 306-316. Korna\u015b S, Cabaret J, Skalska M, Nowosad B (2010) Horse infection with intesitnal helminths in relation to age, sex, access to grass and farm system. Vet Parasitol 174: 285-291. Kuzmina TA, Dzeverin I,&nbsp;Kharchenko VA (2016) Strongylids in domestic horses: Influence of horse age, breed and deworming programs on the strongyle parasite community. Vet Parasitol 227: 56-63. Kuzmina TA, Kharchenko VO (2008) Anthelmintic resistance in cyathostomins of brood horses in Ukraine and influence of anthelmintic treatments on strongylid community structure. Vet Parasitol 154: 277-288. Lassen B, Peltola SM (2015) Anthelmintic resistance of intestinal nematodes to ivermectin and pyrantel in Estonian horses. J Helminthol 89:&nbsp;760-763. Lyons ET,&nbsp;Tolliver SC, Kuzmina&nbsp;TA (2012) Investigation of strongyle EPG values in horse mares relative to known age, number positive, and level of egg shedding in field studies on 26 farms in Central Kentucky (2010-2011). Parasitol Res&nbsp;110:&nbsp;2237-2245. Molento MB, Antunes J, Bentes RN, Coles GC (2008) Anthelmintic resistant nematodes in Brazilian horses. Vet Rec 162: 384-385. Nareaho A, Vainio K, Oksanen A (2011) Impaired efficacy of ivermectin against Parascaris equorum, and both ivermectin and pyrantel against strongyle infections in trotter foals in Finland. Vet Parasitol 182: 372-377. Nielsen MK, Banahan M, Kaplan RM (2020) Importation of macrocyclic lactone resistant cyathostomins on a US thoroughbred farm. Int J Parasitol Drugs Drug Resist 14: 99-104. Nielsen MK, Haaning N, Olsen SN (2006) Strongyle egg shedding consistency in horses on farms using selective therapy in Denmark. Vet Parasitol 135: 333-335. Nielsen MK, Sauermann CW, Leathwick DM (2019) The effect of climate, season, and treatment intensity on anthelmintic resistance in cyathostomins: a modelling exercise Vet Parasitol 269: 7-12. Osterman-Lind E, Holmberg M, Grandi G (2023) Selective Anthelmintic Treatment in Horses in Sweden Based on Coprological Analyses: Ten-Year Results. Animals 13: 2741. Osterman-Lind E, Kuzmina T, Uggla A, Waller PJ, H\u00f6glund J (2007) A field study on the effect of some anthelmintics on cyathostomins of horses in Sweden. Vet Res Commun 31: 53-65. Sangster NC, Dobson RJ (2002) Anthelmintic resistance. In: Lee DL"},{"key":"#cr-split#-ref0.2","unstructured":"(ed) The Biology of Nematodes. CRC Press Taylor and Francis Group, London and New York, pp 531-567. Studzi\u0144ska MB, Demkowska-Kutrzepa M, Bogucki J, Rocze\u0144-Karczmarz M, Tomczuk K (2017) Influence of horse management systems in south-western Poland on the prevalence and intensity of gastrointestinal parasites. Med Weter 73: 721-725. Studzi\u0144ska MB, Sall\u00e9 G, Rocze\u0144-Karczmarz M, Szczepaniak K, Demkowska-Kutrzepa M, Tomczuk K (2020) A survey of ivermectin resistance in Parascaris species infected foals in south-eastern Poland. Acta Vet Scand 62: 28. Studzi\u0144ska MB, Tomczuk K, Sadzikowski AB (2008) Prevalence of Eimeria leuckarti in young horses and usefulness of some coproscopical methods for its detection. Bull Vet Inst Pulawy 52: 541-544. Tomczuk K, Kostro K, Szczepaniak KO, Grzybek M, Studzi\u0144ska M, Demkowska-Kutrzepa M, Rocze\u0144-Karczmarz M (2014) Comparison of the sensitivity of coprological methods in detecting Anoplocephala perfoliata invasions. Parasitol Res 113: 2401-2406. Traversa D, Castagna G, von Samson-Himmelstjerna G, Meloni S, Bartolini R, Geurden T, Pearce MC, Woringer E, Besognet B, Milillo P, D'Espois M (2012) Efficacy of major anthelmintics against horse cyathostomins in France. Vet Parasitol 188: 294-300. Traversa D, Klei TR, Iorio R, Paoletti B, Lia RP, Otranto D, Sparagano OA, Giangaspero A (2007) Occurrence of anthelmintic resistant equine cyathostome populations in central and southern Italy. Prev Vet Med 82: 314-320. Traversa D, von Samson-Himmelstjerna G, Demeler J, Milillo P, Sch\u00fcrmann S, Barnes H, Otranto D, Perrucci S, Di Regalbono AF, Beraldo P, Boeckh A, Cobb R (2009) Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany. Parasit Vectors 2 (Suppl 2): S2. Vidyashankar AN, Kaplan RM, Chan S (2007) Statistical approach to measure the efficacy of anthelmintic treatment on horse farms. Parasitology 134: 2027-2039. Zaj\u0105c AM, Conboy GA, Little SE, Reichard MV (2021) Fecal Examination for the Diagnosis of Parasitism. In: Veterinary Clinical Parasitology. 9th ed., Wiley-Blackwell, pp 1-41. &nbsp;"}],"container-title":["Polish Journal of Veterinary Sciences"],"original-title":[],"language":"pl","link":[{"URL":"https:\/\/journals.pan.pl\/Content\/136419\/PDF\/9%20_%20Studzinska.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T08:34:46Z","timestamp":1758098086000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pan.pl\/dlibra\/publication\/156069\/edition\/136419\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,16]]},"references-count":2,"URL":"https:\/\/doi.org\/10.24425\/pjvs.2025.156069","relation":{},"ISSN":["1505-1773"],"issn-type":[{"value":"1505-1773","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,16]]}}}