{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:48:43Z","timestamp":1773866923910,"version":"3.50.1"},"reference-count":1,"publisher":"Polish Academy of Sciences Chancellery","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>This study investigated the clinical and immunological efficacy of combining Malva sylvestris L. extract with levamisole in calves naturally affected by bovine trichophytosis. Forty clinically diagnosed calves (8\u201311 months old) were randomly allocated into four groups: Control, Malva, Levamisole, and Combination. All animals received subcutaneous ivermectin (0.2 mg\/kg) ten days before treatment and were maintained under uniform housing, feeding, and management conditions throughout the study. Treatments were applied for 21 days: Control (distilled water + saline), Malva (M. sylvestris extract + saline), Levamisole (distilled water + levamisole, 2.5 mg\/kg), and Combination (both treatments). Lesion diameters were recorded on days 0 and 21. Blood samples collected on days 0, 7, 14, and 21 were analysed for leukocyte profiles and serum IgG, IL-6, and IFN-\u03b3 concentrations. The Combination group exhibited the most pronounced reduction in lesion size (p\u22640.05) and marked elevations in leukocyte counts and IgG levels (p\u22640.01). IL-6 concentrations significantly decreased in the Malva group by day 21 (p\u22640.001), whereas IFN-\u03b3 levels showed notable increases in the Levamisole and Combination groups (p\u22640.001). Overall, these findings underscore the therapeutic potential of integrating topical M. sylvestris with systemic levamisole as an effective complementary strategy for managing bovine dermatophytosis.<\/jats:p>","DOI":"10.24425\/pjvs.2026.158498","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:02:01Z","timestamp":1773838921000},"page":"31-31","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and immunological effects of Malva sylvestris and levamisole combination in the treatment of trichophytosis in cattle"],"prefix":"10.24425","author":[{"given":"E.","family":"Dogan","sequence":"first","affiliation":[{"name":"Department of Laboratory and Veterinary Health, Nihat Delibalta G\u00f6le Vocational School, University of Ardahan, 75700, Ardahan, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"37468","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref0","unstructured":"Abdullah TK, Wadee SA, Owain MS (2021) Isolation, diagnosis and incidence of ringworm in cattle in salah al-din governorate. 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Biomed Pharmacother 95: 679-684."}],"container-title":["Polish Journal of Veterinary Sciences"],"original-title":[],"language":"pl","link":[{"URL":"https:\/\/journals.pan.pl\/Content\/138525\/3%20_%20Dogan.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:25:58Z","timestamp":1773840358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.pan.pl\/dlibra\/publication\/158498\/edition\/138525\/content"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,17]]},"references-count":1,"URL":"https:\/\/doi.org\/10.24425\/pjvs.2026.158498","relation":{},"ISSN":["1505-1773"],"issn-type":[{"value":"1505-1773","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,17]]}}}