{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:35:04Z","timestamp":1764131704632},"reference-count":49,"publisher":"American Veterinary Medical Association (AVMA)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n<jats:sec id=\"s001\">\n<jats:title>OBJECTIVE<\/jats:title>\n<jats:p>To evaluate intradiskal pressure (IDP) in the C6-7 intervertebral disk (IVD) after destabilization and distraction-fusion of the C5-C6 vertebrae.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s002\">\n<jats:title>SAMPLE<\/jats:title>\n<jats:p>7 cadaveric C4-T1 vertebral specimens with no evidence of IVD disease from large-breed dogs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s003\">\n<jats:title>PROCEDURES<\/jats:title>\n<jats:p>Specimens were mounted in a custom-made 6 degrees of freedom spinal loading simulator so the C5-C6 and C6-C7 segments remained mobile. One specimen remained untreated and was used to assess the repeatability of the IDP measurement protocol. Six specimens underwent 3 sequential configurations (untreated, partial diskectomy of the C5-6 IVD, and distraction-fusion of the C5-C6 vertebrae). Each construct was biomechanically tested under neutral, flexion, extension, and right-lateral bending loads. The IDP was measured with a pressure transducer inserted into the C6-7 IVD and compared between the nucleus pulposus and annulus fibrosus and across all 3 constructs and 4 loads.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s004\">\n<jats:title>RESULTS<\/jats:title>\n<jats:p>Compared with untreated constructs, partial diskectomy and distraction-fusion of C5-C6 decreased the mean \u00b1 SD IDP in the C6-7 IVD by 1.3 \u00b1 1.3% and 0.8 \u00b1 1.3%, respectively. During motion, the IDP remained fairly constant in the annulus fibrosus and increased by 3.8 \u00b1 3.0% in the nucleus pulposus. The increase in IDP within the nucleus pulposus was numerically greatest during flexion but did not differ significantly among loading conditions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"s005\">\n<jats:title>CONCLUSIONS AND CLINICAL RELEVANCE<\/jats:title>\n<jats:p>Distraction-fusion of C5-C6 did not significantly alter the IDP of healthy C6-7 IVDs. Effects of vertebral distraction-fusion on the IDP of adjacent IVDs with degenerative changes, such as those in dogs with caudal cervical spondylomyelopathy, warrant investigation.<\/jats:p>\n<\/jats:sec>","DOI":"10.2460\/ajvr.20.12.0218","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T18:21:47Z","timestamp":1635963707000},"page":"1003-1012","source":"Crossref","is-referenced-by-count":1,"title":["Ex vivo study of the intradiskal pressure in the C6-7 intervertebral disk after experimental destabilization and distraction-fusion of the C5-C6 vertebrae in canine cadaveric specimens"],"prefix":"10.2460","volume":"82","author":[{"given":"Sebastian C.","family":"Knell","sequence":"first","affiliation":[{"name":"From the Clinic for Small Animal Surgery, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Park","sequence":"additional","affiliation":[{"name":"From the Clinic for Small Animal Surgery, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Voumard","sequence":"additional","affiliation":[{"name":"Musculoskeletal Biomechanics, ARTORG Center for Biomedical Engineering Research, University of Bern, CH-3010 Bern, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pozzi","sequence":"additional","affiliation":[{"name":"From the Clinic for Small Animal Surgery, Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1272","reference":[{"issue":"5","key":"ref1","series-title":"Vet Clin North Am Small Anim Pract","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.cvsm.2010.06.003","article-title":"Cervical spondylomyelopathy (wobbler syndrome) in dogs","volume":"40","author":"da Costa RC","year":"2010","unstructured":"da Costa RC. 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