{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T21:09:38Z","timestamp":1775768978138,"version":"3.50.1"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    \u2014To determine the origin of the nonacid\n(nonparietal) component of gastric secretions in horses\ninduced by pentagastrin infusion.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Animals<\/jats:bold>\n                    \u20146 horses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Procedure<\/jats:bold>\n                    \u2014A Latin square design was used, involving\n6 horses, 3 treatments, and 2 duodenal intubation\nconditions (catheter with balloon to obstruct pylorus\n[B] or without balloon allowing movement of contents\nbetween stomach and duodenum [NB]). Each horse\nhad an indwelling gastric cannula and a catheter positioned\nin the duodenum. Gastric and duodenal contents\nwere collected during 15-minute periods. Each\nexperiment consisted of serial collection periods:\nbaseline; infusion of pyrilamine maleate (1 mg\/kg of\nbody weight, IV); not treated; and IV infusion of saline\n(0.9% NaCl) solution alone, saline solution containing\npentagastrin (6 \u00b5g\/kg\u00b7h), or saline solution containing\nhistamine (30 \u00b5g\/kg\u00b7h). Volume of samples was\nrecorded, and electrolyte concentrations were measured.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    \u2014Pentagastrin and histamine stimulated\nmaximal acid output; however, during NB conditions,\npentagastrin-induced concentration of hydrogen\nions was significantly less than during histamine or\npentagastrin infusions during B conditions. The large\nvolume produced in response to pentagastrin during\nNB conditions was accompanied by increased sodium\nion output that was greater than for pentagastrin\nduring B conditions, but both values were significantly\ngreater than values for histamine during B or\nNB conditions.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\n                    \u2014Nonparietal\nsecretions collected during IV infusion of pentagastrin\nare duodenal in origin. Reflux of duodenal contents\ninto the stomach of horses is enhanced by pentagastrin.\nFlow of duodenal contents into the stomach\ncould have implications in the pathogenesis of ulcers\nin horses. (\n                    <jats:italic>Am J Vet Res<\/jats:italic>\n                    2000;61:1133\u20131139)\n                  <\/jats:p>","DOI":"10.2460\/ajvr.2000.61.1133","type":"journal-article","created":{"date-parts":[[2005,12,6]],"date-time":"2005-12-06T12:12:48Z","timestamp":1133871168000},"page":"1133-1139","source":"Crossref","is-referenced-by-count":15,"title":["Effect of pyloric blockade and infusion of histamine or pentagastrin on gastric secretion in horses"],"prefix":"10.2460","volume":"61","author":[{"given":"Diane L.","family":"Kitchen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Burrow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie S.","family":"Heartless","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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