{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:22:09Z","timestamp":1770218529643,"version":"3.49.0"},"reference-count":24,"publisher":"American Veterinary Medical Association (AVMA)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To determine the mode of inheritance of\nvon Willebrand's disease (vWD) and perform linkage\nanalysis between vWD and coat color or narcolepsy\nin a colony of Doberman Pinschers.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u2014159 Doberman Pinschers.<\/jats:p>\n\t\t\t\t<jats:p><jats:bold>Procedure<\/jats:bold>\u2014von Willebrand factor antigen (vWF:Ag)\nconcentration was measured by use of ELISA, and\nresults were used to classify dogs as having low\n(&lt; 20%), intermediate (20 to 65%), or high (&gt; 65%)\nvWF:Ag concentration, compared with results of\nanalysis of standard pooled plasma. Buccal bleeding\ntime was measured, and mode of inheritance of vWD\nwas assessed by pedigree analysis.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014von Willebrand's disease was transmitted\nas a single autosomal gene defect. Results suggested\nthat 27.04% of dogs were homozygous for vWD,\n62.26% were heterozygous, and 10.69% did not\nhave the defect. Most homozygous and some heterozygous\ndogs had prolonged bleeding times. Dogs\nwith diluted coat colors (blue and fawn) were significantly\noverrepresented in the homozygous group,\ncompared with black and red dogs, but a significant\nlink between vWD and coat color was not detected.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014von\nWillebrand's disease is transmitted as an autosomal\ndominant trait with variable penetrance; most dogs in\nthis colony (89.3%) were carriers of vWD.\nHomozygosity for vWD is not likely to be lethal. Some\nheterozygous dogs have prolonged bleeding times.\nAn association between diluted coat colors and vWD\nmay exist. 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