{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T17:20:18Z","timestamp":1694625618439},"reference-count":45,"publisher":"American Veterinary Medical Association (AVMA)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ajvr"],"published-print":{"date-parts":[[2000,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Objective<\/jats:bold>\u2014To document blood nitric oxide concentrations\nin the portal vein and systemic circulation in a rat\nmodel of acute portal hypertension and compare values\nwith a control group and a sham surgical group.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Animals<\/jats:bold>\u201430 rats; 10 controls (group 1), 10 sham surgical\n(group 2), and 10 rats with surgically induced\nacute portal hypertension (group 3).<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Procedure<\/jats:bold>\u2014Following induction of anesthesia,\ncatheters were placed surgically in the carotid artery,\njugular, and portal veins of group 2 and 3 rats and in\nthe carotid artery and jugular vein of group 1 rats.\nBaseline heart and respiratory rates, rectal temperature,\nand vascular pressure measurements were\nobtained, and blood was drawn from all catheters for\nbaseline nitric oxide (NO) concentrations. Acute portal\nhypertension was induced in the group 3 rats by tying\na partially occluding suture around the portal vein and\na 22-gauge catheter. The catheter was then removed,\nresulting in a repeatable degree of portal vein impingement.\nAfter catheter placement, all variables were\nremeasured at 15-minute intervals for 3 hours.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Results<\/jats:bold>\u2014Blood nitric oxide concentrations were greater\nin all vessels tested in group 3 than in group 2 rats.<\/jats:p>\n\t\t\t\t<jats:p>\n\t\t\t\t\t<jats:bold>Conclusions and Clinical Relevance<\/jats:bold>\u2014Acute portal\nhypertension in this experimental model results in\nincreased concentrations of NO in the systemic and\nportal circulation. On the basis of information in the\nrat, it is possible that increased NO concentrations\nmay develop in dogs following surgical treatment of\ncongenital portosystemic shunts if acute life-threatening\nportal hypertension develops. Increased NO\nconcentrations may contribute to the shock syndrome\nthat develops in these dogs. 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The surprising life of nitric oxide. 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